Gates / Johns Hopkins Wuhan trial run in october 2019

Firstly lets run up a few interesting coincidences:

- Wuhan, home to the only BSL-4 biolab in China
- China contacts WHO dec. 31st
- US CDC pinpoints market 24 hours later (?!)
- sars source was not found that fast
- Streets in Wuhan being smoked
- Doctors crying over number of patients
- As of jan 23: 25 dead and over 650 cases

Now to the point. Back in october 2019 Johns Hopkins held a joint event with the Gates that looked on how prepared we are for a pandemic event. How it would likely take place and how we would handle it.
Speed up to december 12.... Forbes decides to post an article about this event.
December 12/13 also happens to be the first day CV started spreading.

Just coincidences all of it??? Quite a few eh....
Event 201

a reply to: flice

The experts ran through a carefully designed, detailed simulation of a new (fictional) viral illness called CAPS or coronavirus acute pulmonary syndrome. This was modeled after previous epidemics like SARS and MERS.

That is a bit more inventive than "Wu-flu"!! LOL!!

What gets me is that the article starts off with a picture of a lady feeding a bunch of chickens in open air cages.

Why snakes? So, the official story is, snakes, open air market, snake feces, into poultry, then pigs, then humans. All in the month of December. 24-hours for the CDC to nail it down, now 3 cities closed off?? Hum? That sounds slipperier than snake... well, you know the rest!!

Maybe we should do what all good CTs do, and follow the money.

The coronavirus happens to have a patent on it.. Lab made and engineered..a reply to: TEOTWAWKIAIFF

a reply to: flice

now I need to look some of this stuff up (would have been nice if you included sources for all of this, not that I don't believe what is stated)

Mexico may have a confirmed case now as well it sounds like? The next 5-10 days we could see it on a few more continents...

patents.justia.com...

Jul 23, 2015 - THE PIRBRIGHT INSTITUTE

WHO know's..

This seemed an appropriate video for the viewing pleasure...

a reply to: flice

Science. It will kill us all yet.

originally posted by: Bigbrooklyn
The coronavirus happens to have a patent on it.. Lab made and engineered..a reply to: TEOTWAWKIAIFF

FIELD OF THE INVENTION

The present invention relates to an attenuated coronavirus comprising a variant replicase gene, which causes the virus to have reduced pathogenicity. The present invention also relates to the use of such a coronavirus in a vaccine to prevent and/or treat a disease.

Claims

1. A live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or both of non-structural protein(s) nsp-10 and nsp-14, wherein the variant replicase gene encodes a protein comprising an amino acid mutation of Pro to Leu at the position corresponding to position 85 of SEQ ID NO: 6, and/or wherein the variant replicase gene encodes a protein comprising an amino acid mutation of Val to Leu at the position corresponding to position 393 of SEQ ID NO: 7.

2. The coronavirus according to claim 1 wherein the variant replicase gene encodes a protein comprising one or more amino acid mutations selected from:

an amino acid mutation of Leu to Ile at the position corresponding to position 183 of SEQ ID NO: 8; andan amino acid mutation of Val to Ile at the position corresponding to position 209 of SEQ ID NO: 9.

3. The coronavirus according to claim 1 wherein the replicase gene encodes a protein comprising the amino acid mutations Val to Leu at the position corresponding to position 393 of SEQ ID NO: 7; Leu to Ile at the position corresponding to position 183 of SEQ ID NO: 8; and Val to Ile at the position corresponding to position 209 of SEQ ID NO: 9.

4. The coronavirus according to claim 1 wherein the replicase gene encodes a protein comprising the amino acid mutations Pro to Leu at the position corresponding to position 85 of SEQ ID NO: 6; Val to Leu at the position corresponding to position 393 of SEQ ID NO: 7; Leu to Ile at the position corresponding to position 183 of SEQ ID NO: 8; and Val to Ile at the position corresponding to position 209 of SEQ ID NO: 9.

5. The coronavirus according to claim 1 wherein the replicase gene comprises at least one nucleotide substitutions selected from: compared to the sequence shown as SEQ ID NO: 1.

C to Tat nucleotide position 12137; andG to C at nucleotide position 18114;compared to the sequence shown as SEQ ID NO: 1;and optionally, comprises one or more nucleotide substitutions selected from T to A at nucleotide position 19047; andG to A at nucleotide position 20139;

6. The coronavirus according to claim 1 which is an infectious bronchitis virus (IBV).

7. The coronavirus according to claim 1 which is IBV M41.

8. The coronavirus according to claim 7, which comprises an S protein at least, part of which is from an IBV serotype other than M41.

9. The coronavirus according to claim 8, wherein the S1 subunit is from an IBV serotype other than M41.

10. The coronavirus according to claim 8, wherein the S protein is from an IBV serotype other than M41.

11. The coronavirus according to claim 1 which has reduced pathogenicity compared to a coronavirus expressing a corresponding wild-type replicase, wherein the virus is capable of replicating without being pathogenic to the embryo when administered to an embryonated egg.

12. A variant replicase gene as defined in claim 1.

13. A protein encoded by a variant coronavirus replicase gene according to claim 12.

14. A plasmid comprising a replicase gene according to claim 12.

15. A method for making the coronavirus according to claim 1 which comprises the following steps:

(i) transfecting a plasmid according to claim 14 into a host cell;(ii) infecting the host cell with a recombining virus comprising the genome of a coronavirus strain with a replicase gene;(iii) allowing homologous recombination to occur between the replicase gene sequences in the plasmid and the corresponding sequences in the recombining virus genome to produce a modified replicase gene; and(iv) selecting for recombining virus comprising the modified replicase gene.

16. The method according to claim 15, wherein the recombining virus is a vaccinia virus.

17. The method according to claim 15 which also includes the step:

(v) recovering recombinant coronavirus comprising the modified replicase gene from the DNA from the recombining virus from step (iv).

18. A cell capable of producing a coronavirus according to claim 1.

19. A vaccine comprising a coronavirus according to claim 1 and a pharmaceutically acceptable carrier.

20. A method for treating and/or preventing a disease in a subject which comprises the step of administering a vaccine according to claim 19 to the subject.

21. The method of claim 20, wherein the disease is infectious bronchitis (IB).

22. The method according to claim 20 wherein the method of administration is selected from the group consisting of; eye drop administration, intranasal administration, drinking water administration, post-hatch injection and in ovo injection.

23. The method according to claim 21 wherein the administration is in ovo vaccination.

24. A method for producing a vaccine according to claim 19, which comprises the step of infecting a cell according to claim 18 with a coronavirus according to claim 1.

25. The coronavirus according to claim 1, further comprising a mutation in one or both of nsp-15 and nsp-16.

Patent Link

originally posted by: flice
Firstly lets run up a few interesting coincidences:

- Wuhan, home to the only BSL-4 biolab in China
- China contacts WHO dec. 31st
- US CDC pinpoints market 24 hours later (?!)
- sars source was not found that fast
- Streets in Wuhan being smoked
- Doctors crying over number of patients
- As of jan 23: 25 dead and over 650 cases

Now to the point. Back in october 2019 Johns Hopkins held a joint event with the Gates that looked on how prepared we are for a pandemic event. How it would likely take place and how we would handle it.
Speed up to december 12.... Forbes decides to post an article about this event.
December 12/13 also happens to be the first day CV started spreading.

Just coincidences all of it??? Quite a few eh....
Event 201

Yep too much of a coincidence especially if you believe in Signs and there are no coincidences ..

www.nature.com... e-chinese-lab-poised-to-study-world-s-most-dangerous-pathogens-1.21487

A laboratory in Wuhan is on the cusp of being cleared to work with the world’s most dangerous pathogens. The move is part of a plan to build between five and seven biosafety level-4 (BSL-4) labs across the Chinese mainland by 2025, and has generated much excitement, as well as some concerns.

#1 why build it in a city of 11 million people?  Isolate the lab unless...

a reply to: M4ngo

Talk about playing with fire!

Multiple species (lizard, avian, mammal) with multiple variants with multiple vectors?!!

Didn’t any of the scientists watch any movies from 1990 to 2010??!! A bunch were based on a virus “getting let into the wild” and the consequences (zombies, mega deth,nuclear bombs, end of civilization, dogs and cats living together... total chaos!)

Add to the mix viruses appear to a step ahead of our ability to eradicate them. Just, wow!

And the damn thing does not need to be airborne from the get go to study it!!

Man, if weirdos are injecting themselves to be transhuman then who (WHO, lol) knows what else is allowed to happen??

My guess, the CV was genetically tagged and that is how they knew it’s origins.

Anybody keeping an eye on the vax manufactures and the rates of sickness in their main office area?? May be nothing but then again...

a reply to: flice

Did anyone happen to notice the new show Netflix is featuring this week? Pandemic - which is a documentary series about the dangers of a flu outbreak.

Seems way too coincidental to me.

The genetic genie was released from it's bottle long before I was born. It wouldn't surprise me to learn that every new disease from the early 20th century to the present was tinkered with in an attempt to weaponize it.

I have come across a lot of information in my own lifetime that confirms to me that many incurable viral human (and animal) diseases were altered in a lab and breached containment both by accident and on purpose.

The MSM gloss over is pathetic at best. Here is an article that has a bit more of information (and real medical data) behind.

Disclaimer: Just because it has "science" behind doesn't mean it is true, just that it is a bit more believable than snake crap!

The new coronavirus rapidly spreading in China and nearby countries seems to trigger symptoms similar to those seen in the severe acute respiratory distress syndrome (SARS) coronavirus outbreak in 2003, two new studies show.

Me: The headline can be misread as "this virus has been studied in the lab, twice" which made me do a double take. It is not until later that you find out what they actually mean: in a "compare and contrast" study...

Published Jan. 24 in The Lancet journal, these are the first clinical studies conducted on patients struck by the new coronavirus, dubbed 2019-nCoV. As of Friday morning, there were 830 confirmed cases and 26 deaths in China tied to the coronavirus, which originated in the central Chinese city of Wuhan.

Me: Still not as cool a names as "CAPS"!! lulz! For the TL;DR crowd, the two studies are then detailed. The first one documents the first 41 cases in Wuhan from December 16 to January 2. The second case study followed a family of 7 who came back from Wuhan. That one kind of shoots the "it came from open food markets" plot out of the water because none of the family members visited open air markets (one, a mother, actually wore a mask and remained nCoV free). What it really tells us is the coronavirus was already airborne and being transmitted person-to-person.

The compare and contrast to SARS is really scary...

Similar to the 2003 SARS outbreak in China, most patients who came down with the Wuhan coronavirus were healthy, without any chronic underlying health issues. And symptoms also resembled those of SARS […]

All of the hospitalized patients had developed pneumonia, nearly all (98%) had a fever, three-quarters developed a cough, 44% felt fatigued, and 55% had some shortness of breath. Symptoms such as headache or diarrhea were rare, however.

On the other hand, "despite sharing some similar symptoms to SARS [such as fever, dry cough, shortness of breath], there are some important differences," Cao said in a Lancet news release.

For example, people with the new virus typically didn't have runny noses or other symptoms involving the upper respiratory tract, he said. And very few had intestinal symptoms such as diarrhea, which occurred in about a quarter of SARS patients.

Severe illness—enough to require admittance to the ICU—occurred in about a third of the hospitalized patients, Cao's team said, and six patients died.

MedicalExpress.com, news, Jan. 24, 2020 - First clinical studies find Wuhan virus closely resembles SARS.

2019-nCoV sounds nasty! You are not coughing, or ill with flu symptoms, just feel crummy then it hits you as pneumonia (they mention the "cytokine storm" but do not elaborate). Like the Spanish Flu from WWI, totally healthy people, no underlying causes or weak immune systems, become walking virus carries! Those who have it need a 5 - 10 day bake-in period then the sickness starts. Or you remain symptom free and are just a carrier.

That is just wrong! This has the potential of being "worse than flu season" as it can pop up anywhere people are for gawd knows how long!

Gene tests revealed that five of the family members carried a form of 2019-nCoV that had a type of protein allowing it to enter healthy cells. Yuen's team was also able to use samples from two patients to map the full genome of 2019-nCoV.

"With the improved surveillance network and laboratory capability developed following the SARS pandemic, China has now been able to recognize this new outbreak within a few weeks and has made the virus genome publicly available to help control its spread," said study co-author Dr. Rosana Wing-Shan Poon

Buried at the bottom of the article is the reason why they were able to track this virus down: because they were not prepared for SARS (unless like me, you think it is somehow id coded by lab to tell which one it came from).

And it still does nothing to address OP's "coincidences".

Quote from the John Hopkins website, page on "Events".

Odd that the 201 Event date is "predicted" by the posting date below the event text. As well, the "201" link goes to an exercise with "clade" in the name that took place in 2018, not 2019.

Note that in the other events quoted, the dates line up logically, but not in the case of the "201" event.

Website text diddled by somebody?

Cheers

2019

Event 201
The Johns Hopkins Center for Health Security in partnership with the World Economic Forum and the Bill and Melinda Gates Foundation hosted Event 201, a high-level pandemic exercise on October 18, 2019, in New York, NY. The purpose of the exercise was to illustrate the pandemic preparedness efforts, response decisions, and cooperation required from global businesses, governments, and public health leaders that the world will need to diminish the large-scale economic and societal consequences of a severe pandemic.
May 15, 2018

Biosafety and Biosecurity in the Era of Synthetic Biology: Meeting the Challenges in China and the United States
On Friday, July 26, 2019, the Johns Hopkins Center for Health Security and the Tianjin University Center for Biosafety Research and Strategy co-hosted an event that brought together leading experts and emerging leaders from China and the US to discuss the ways, both positive and negative, that synthetic biology may alter the social and economic frameworks of modern humanity.
July 26, 2019

Center news: August 14, 2019

The US Bioeconomy: Maximizing Opportunities for Economic Growth and National Security with Biology
On July 16, the Johns Hopkins Center for Health Security and Ginkgo Bioworks convened a meeting in Washington, DC, to solicit stakeholder input on specific ways that national policy can strengthen the US bioeconomy. The aims of the meeting were to consider the benefits to the US if its bioeconomy were to be expanded; examine the current health of the US bioeconomy; discuss existing US government programs, policies, and initiatives related to the bioeconomy; and identify priorities for strengthening the US bioeconomy.
July 16, 2019

JH Site

Paydirt. The website has been altered to redirect the Event 201 link to a report about a 2018 exercise.

Here is JH webpage on the Event 201 exercise, which now has to be searched for and cannot be directly accessed from their "Events" page.

Somebody getting nervous? Naughty, naughty.

ETA. Nervous indeed. Check out the JH page med-splainin' their exercise and its similarity to the current outbreak. They even state they don't believe 65 million people will really die!

Cheers

Another odd aspect about the JH website page on their "events".

Wayback machine archiving of that page does not exist after June 15, 2019. Makes it hard to determine when the hyperlink on the Events page was changed to redirect the "Event 201" hyperlink to the "clade" event that happened in 2018.

Tracks, they ARE being covered. Save copies of these pages before they go 404.

Cheers

One more weird thing about the wayback machine archiving. The main JH site hasn't been archived since December. But the two pages I mentioned -have- been archived since then -- today, to be specific.

😷

Cheers

Players at Event 201

These were the principal participants in the Event 201 drill that took place at John Hopkins. I don't really recognize any of them, but there are some interesting connections.

Sofia Borges is the UN Foundation’s Senior Vice President and Head of the New York office. In this role, she serves as chief liaison with United Nations leadership and the diplomatic community

Professor George F. Gao is the Director-General, Chinese Center for Disease Control and Prevention; a Professor in the Institute of Microbiology, Chinese Academy of Sciences; President of the Chinese Society of Biotechnology; and President of the Asian Federation of Biotechnology (AFOB).

During the last administration, Dr. (Avril) Haines served as Assistant to the President and Principal Deputy National Security Advisor. She also served as the Deputy Director of the Central Intelligence Agency and Legal Adviser to the National Security Council.

Hasti Taghi is the Executive Advisor to the Chairman of Advertising & Partnerships at NBCUniversal. In her role, she serves in a chief of staff capacity as a liaison between the executive team and the chairman. She also leads strategic initiatives for the office, including partnerships with the World Economic Forum.

(Infotainment background with major networks)

Cheers

The Event 201 Scenario

The Event 201 scenario

Event 201 simulates an outbreak of a novel zoonotic coronavirus transmitted from bats to pigs to people that eventually becomes efficiently transmissible from person to person, leading to a severe pandemic. The pathogen and the disease it causes are modeled largely on SARS, but it is more transmissible in the community setting by people with mild symptoms.

Although at first some countries are able to control it, it continues to spread and be reintroduced, and eventually no country can maintain control.

There is no possibility of a vaccine being available in the first year. There is a fictional antiviral drug that can help the sick but not significantly limit spread of the disease.

The scenario ends at the 18-month point, with 65 million deaths.

The model used for the Event 201 exercise

The Event 201 "Call to Action"

Among the "call to action" recommendations: Keep traveling and trading!!

Make of all this what you will.

Cheers