Novel Dementia Vaccine On Track For Human Trials Within Two Years

originally posted by: network dude
My father is currently suffering from this disease, as did my grandfather. It's horrible and unfair. He was a computer programmer. For those of you making #ing idiotic comments, I pray you remain stupid about this disease, as it's hell on the family and I'd not want you to find out how bad it really it.

We can agree on that. I spent a year as the caregiver for my mom til she died. Iv'e heard "micro-dosing" is a viable preventive measure.

The way that they think that vaccine works doesn't make sense. If they are stimulating antibodies against tau and amyloid plaques, that could lead to some more severe problems. The Adjuvant is probably something to bring it through the blood brain barrier, that is not the problem. This may work in mice, mice which have had protective measures knocked out, but that is not the same as giving it to a person to ward off a potential threat, high dopamine levels lead to a potential threat. I could see them giving a supplemental enzyme, but this does not sound right at all. Even giving people some taurine to help stop the problem sounds reasonable...but maybe a little too cheap since taurine can be bought all over.

Mice do not think, just because they do not build up any tau or plaque does not mean they can still read...because mice can't read. I would never want to be on a test for this, memories are prion like too, will it wipe out short term memory in people?

The effects might take many years to become noticable. There are better ways to address the disease, just adjust the diet to lower the risk, it would work in seventy percent of people who have increased risk.

Treatments for alzheimer have been very bad, they targeted something with elevated levels in alzheimer meds and used a med to stop the enzyme, the enzyme was actually trying to protect the brain....they made the people a lot worse in the end sending them to the nursing home way before their time. Of course, this chemistry was supposedly taken silently off of the market, with a few instances remaining where it can be used, but not for alzheimer disease anymore.

I am a mouse, not a guinney pig. I have an elevated genetic risk and I have adjusted my diet to compensate so I will have lay less risk of getting it. It actually saved us money because now we get great homecooked meals and avoid junk foods that actually raise the risk. The keto diet helps reduce risk, but a straight keto diet can also cause some other problems that could be just as bad.

a reply to: andy06shake

This is interesting, since vaccines stop a disease agent from infecting a person. What is the disease agent that causes dementia or Alzheimers? It's not a virus, b/c vaccines don't work against viruses. A bacteria?

originally posted by: olaru12

originally posted by: network dude
My father is currently suffering from this disease, as did my grandfather. It's horrible and unfair. He was a computer programmer. For those of you making #ing idiotic comments, I pray you remain stupid about this disease, as it's hell on the family and I'd not want you to find out how bad it really it.

We can agree on that. I spent a year as the caregiver for my mom til she died. Iv'e heard "micro-dosing" is a viable preventive measure.

Sorry to hear that man. Unfortunately a similar situation will play out in the not to distant future of my Saint of a Madre.

On a lighter note.... You wouldn't have to sell me on micro to prevent diseases. I'd do it anyways.

a reply to: rickymouse

There are plenty of drugs on the market that work and yet do not make sense or their mechanisms in the entirety, as to how they function, not known, take Gabapentin for instance.

I suggest if the vaccine turns out to be viable in humans, without any serious long term side effects, it should be marketed and the kinks and understanding worked out later.

That's if it works.

originally posted by: new_here
a reply to: andy06shake

This is interesting, since vaccines stop a disease agent from infecting a person. What is the disease agent that causes dementia or Alzheimers? It's not a virus, b/c vaccines don't work against viruses. A bacteria?

The article read that it would address the proteins' effect on the mind.

Some people are immune to mad cow which is also a prion (they came from lineage who practiced cannibalism). So there is precedence.

a reply to: new_here

Question is above my head im afraid through none the less of interest.

My guess is the problem lies in what we eat and drink, amongst other contributing factors.

originally posted by: andy06shake
a reply to: tanstaafl

If only it was that easy tanstaafl there would be no issue nor problems associated with the disease.

? That comment doesn't make sense.

It is that easy, for the most part. Of course, extremely advanced alzheimers may involve more damage than the body is capable of repairing.

Alzheimer’s is somewhat more complicated a kettle of fish im afraid.

Maybe... aluminum appears to also possibly play a role.

But early onset dementia/alzheimers (as well as type II diabetes) responds dramatically to IF combined with the proper diet - elimination/minimization of added sugar and processed carbs, and full fat animal proteins and whole natural carbs (fruits, vegetables, nuts, etc) - but this isn't the appropriate place to get into great detail on diet.

Not that i don't agree with the sugar intake all the same, but considering it's in just about everything its no exactly realistic prospect to consider.

Actually it is, it just takes a little work, and the willingness to change, but if the willingness and desire aren't there, then yeah, its a no go.

originally posted by: ketsuko
a reply to: tanstaafl

It's not all that.

The grandmother I lost to is was arguably the healthiest of the bunch. Not overweight. Not long-term health conditions. Cooked her stuff from scratch, the old-fashioned way every day ... No highly processed crap, no excessive sugar, etc., they were adhering to my grandfather's heart diet because he had a pacemaker.

She was the one taken by Alzhiemer's.

It isn't directly about sugar, it is about insulin. This is why IF is the most important part, although it also requires eliminating - as much as possible - added sugar and processed carbs. But all foods raise insulin, some much more than others.

That said, there could be other factors. I know aluminum is supposed to be one.

Sorry to hear about your gran...

originally posted by: andy06shake
a reply to: rickymouse

There are plenty of drugs on the market that work and yet do not make sense or their mechanisms in the entirety, as to how they function, not known, take Gabapentin for instance.

I suggest if the vaccine turns out to be viable in humans, without any serious long term side effects, it should be marketed and the kinks and understanding worked out later.

That's if it works.

They know how Neurontin...Gabapentin...works, it works almost like Taurine does but costs a hell of a lot more. Taurine is a neuromodulator...just like gabapentin is. Taurine deficiency is common in alzheimer disease, in the cells, yet unusable Tau-rine is causing problems in the white matter If I am getting it right because of how it is bound from the dying brain cells. Fix the problem that is causing the neurodegeneration, do not create antibodies to clean up the mess afterwards

I have read at least five hundred research articles on this subject and the effect of neurotransmitters on everything involved. Many of the interpretations we are being propagandized to see steer us to believe the only way to fix it is to treat it instead of simply avoiding overconsumption of food chemistries that cause it. They are trying to profit by treating the disease, I am trying to hack into how to never get the disease by observing the evidence and trying to interpret a way to stop it. Dopamine is increased in the brain by many food chemistries, some people lack enough of a particular enzyme that breaks down dopamine and levels get too high. Simply moderating foods that raise dopamine levels can take care of a lot of risk factors.

a reply to: tanstaafl

Makes perfect sense to the multitudes involved in the treatment of the disease, nevermind the people who are trying to find cures.

When people reach an extended age change can become an almost impossibility with regards to many aspect of there life.

So no, its obviously not that easy.

We tried my grandmother with just about everything to no avail, willingness had nothing to do with it.

Lack of knowledge and proper medications to address the disease are the real issue.

At least this type of preventative vaccination may save lives is my thing on the matter.

originally posted by: Ohanka
Personally i’d take the big scary needle over this malnutrition for mental health scheme you’ve got here.

Rotflmao!

Whatever dude, ignorance is bliss...

a reply to: rickymouse

Well, that's not what my GP told me.

Guess you must know better than a trained medical health care professional?

Anyhoo, nice to read you take on the matter.

To my knowledge, and my doctor, Gabapentin or at least the entire mechanism of action as an antiepileptic agent is not completely understood through effective.

a reply to: tanstaafl

Well, Senility and Alzheimer's disease aint no picknick.

And that's about as true as it gets.

originally posted by: andy06shake
a reply to: tanstaafl
Makes perfect sense to the multitudes involved in the treatment of the disease, nevermind the people who are trying to find cures.

Again, your comment, as it was worded, makes no sense.

Just because a symptom has an easy fix, doesn't mean everyone employs the fix. The people suffering are still suffering, unless/until they stumble upon and employ the fix.

When people reach an extended age change can become an almost impossibility with regards to many aspect of there life.

Nothing ventured,. nothing gained - but as I said, if they are willing or able to make the change needed, then yeah, it is what it is.

I had to watch a beloved aunt die from cancer. She wasn't willing to try anything. I tried in vain to at least ger her to stop drinking her 12 pack of diet coke every day, to no avail.

So no, its obviously not that easy.

It is simple... but not always easy.

Lack of knowledge and proper medications to address the disease are the real issue.

Lack of knowledge, yes. Medications - drugs - are never the long term solution to any health problem, they are only stop gaps treating symptoms, and usually causing 2 or 3 new ones (symptoms)...

At least this type of preventative vaccination may save lives is my thing on the matter.

Vaccines are for bacteria and virus. Are you saying you believe alzheimers is caused by a bacteria or virus?

originally posted by: andy06shake
a reply to: tanstaafl

Well, Senility and Alzheimer's disease aint no picknick.

And that's about as true as it gets.

I absolutely agree, never said or intended to suggest otherwise.

All I did was suggest there is a way out of that hole that some may want to try.

a reply to: tanstaafl

Aluminum is a factor. It is a neur0-excitent. Alum in pickles has quite a bit, so do some aluminum ant-acids and some baking powders. Some fast melting cheeses too

Sugar can be a cause too, so can excess carbs, all carbs can stimulate dopamine production which can elevate risk in people who do not make adequate enzymes in the brain to break down dopamine well.....those people should moderate levels of carb intake. Comfort foods stimulate dopamine pretty often.

The amount of enzyme our bodies make to break down dopamine is genetic, some people need more dopamine foods, others need little. Com-t and MAOB are two of the enzymes involved they know of. If you break down dopamine too much, it gives parkinson style symptoms, too little breakdown can lead to alzheimer symptoms. Everyone has to eat different. Too much dopamine in the system will make a person feel great but can't think right, not enough can make a person anxious and twitchy. There is way more to this but I am trying to make a more simple explanation. The more dopamine producing foods a person eats, the more dopamine destroying enzymes you make, but if you can't make much of the enzyme it can cause problems. Those who make a lot of the enzyme get addicted, if they boost the enzyme production they get depleted, then they get the shakes sometimes or withdrawals. Swings in these foods can give highs and lows which winds up like bi-polar, some bi-polar meds try to address this issue, but many times if the person just moderates the diet, no high intake, no low intake of dopamine foods, the person does not have a problem.

All the things I just talked about have some rare times that moderation does not work, but most people on these meds for bipolar and parkinson like symptoms do not need the meds if they learn how to moderate their diet to fit their metabolism. With alzheimer disease, permanent damage is done by long term eating of foods that do not comply with their metabolism. Those genes I talked about just moderate the metabolism.

a reply to: tanstaafl

Ive already said what i think amounts to the main contributing factors where senility and Alzheimer's are concerned.

Pay attention or you may wish to get yourself checked(joke).

The crap in our food and water, nevermind our ever-increasing sedimentary lifestyle, and the fact that people are living longer certainly don't help.

I'm not saying anything with regards to how people actually contract the disease, im not a doctor, nor even a dentist. LoL

a reply to: tanstaafl

Well if your correct mate, scream it from the rooftops would be my thinking on the matter, because people need to know such things.

Somehow i imagine its rather a more complicated affair to contend with all the same, hence our medical establishments lack of headway, ambivalent or otherwise where the disease is concerned.

The palliative care aspect needs to be considered, more monies in that than actual cures i suppose.

Something i would like to see wiped out or at least severely retarded in my lifetime all the same, Alzheimer's and Senility that is.

originally posted by: andy06shake
a reply to: rickymouse

Well, that's not what my GP told me.

Guess you must know better than a trained medical health care professional?

Anyhoo, nice to read you take on the matter.

To my knowledge, and my doctor, Gabapentin or at least the entire mechanism of action as an antiepileptic agent is not completely understood through effective.

Yeah, I probably do know more than most GPs on this subject, because I studied the hell out of Gabapeentin and similar chemistries, reading all sorts of scientific articles. Here is one....just search it for the word Taurine with the find on this page from Edit.
anesthesiology.pubs.asahq.org...

Maybe your GP does not have the time to spend years researching how pharmaceutical chemistry works, after all, they are busy. There are specialists that know more than me on this sort of stuff, I have epilepsy, I cannot take epilepsy drugs because I cannot break them down, so I learned how to control neuroexcitation with basic biochemistries. I have lots of time to study and have taken many medical classes on line.

If you want thirty other articles I can give them to you, or just do it the easy way...google and read, only paying attention to real medical research links.