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LONDON, Sept 20 (Reuters) - British scientists have used a genome editing tool known as CRISPR/Cas9 to knock out a gene in embryos just a few days old, testing the technique's ability to decipher key gene functions in early human development.
The researchers said their experiments, using a technology that is the subject of fierce international debate because of fears that it could be used to create babies to order, will deepen understanding of the biology of early human development.
"One way to find out what a gene does in the developing embryo is to see what happens when it isn't working," said Kathy Niakan, a stem cell scientists who led the research at Britain's Francis Crick Institute.
"Now we have demonstrated an efficient way of doing this, we hope that other scientists will use it to find out the roles of other genes."
Niakan's team decided to use it to stop a key gene from producing a protein called OCT4, which normally becomes active in the first few days of human embryo development.
They spent more than a year optimising their various techniques using mouse embryos and human embryonic stem cells in lab dishes, before starting work on human embryos.
To inactivate OCT4, they used CRISPR/Cas9 to change the DNA of 41 human embryos. After seven days, embryo development was stopped and the embryos were analysed.