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originally posted by: frenchfries
a reply to: TerryDon79
you are saying nothing cancertissue is more acid look it up.... I did not say BLOOD i meant cancertissue.
The extracellular pH in malignant tumors is known to be lower than in normal tissues and may therefore facilitate extracellular activation of secreted lysosomal cathepsins. We have tested the capability of human mammary cells (continuous cell lines and primary culture) to acidify their extracellular environment, using two techniques. By measuring pH changes through alterations of phenolsulfone phthaleine absorbance, we found that the more aggressive MDA-MB-231 human breast cancer cells were more active in acidifying a non-buffered balanced salt solution than the estrogen receptor positive MCF7 and ZR75 cell lines and than normal mammary epithelial cells in primary culture. Metastatic breast cancer cells from pleural effusions were up to 200-fold more active in acidifying their extracellular milieu than non-malignant mammary cells cultured in the same conditions, strongly suggesting that this difference also occurs in vivo. The use of inhibitors in the presence or absence of glucose showed that both lactate and an ATP-driven proton pump sharing some characteristics of the vacuolar H+ pump were involved. Bafilomycin A1, a specific inhibitor of the vacuolar (V-type) ATP-H+ pump inhibited part of the acidification by MCF7 cells, but not by MDA-MB-231 cells. We also used microelectrodes to measure extracellular pH, in close contact to the MCF7 breast cancer cells. The pH at the free surface of MCF7 cells was lower by 0.33 +/- 0.14 unit than that of the surrounding medium, while insertion of the microelectrode tip beneath the attached surface of the cells showed a greater lowering of pH from 0.3 to 1.7 pH unit as long as cell attachment on the substrate prevented H+ diffusion. We conclude that breast carcinoma cells have a higher capacity for acidifying their extracellular milieu than normal mammary cells, and that both a plasma membrane H(+)-ATPase, and lactic acid production are involved in this acidification. It is therefore possible that the aspartyl and cysteinyl pro-cathepsins secreted in excess by tumor cells may be activated extracellularly in vivo close to the basement membrane.
IT'S ALREADY BEEN INVESTIGATED IN THE LAB. IT DOESN'T WORK ON HUMANS.
originally posted by: frenchfries
a reply to: TerryDon79
IT'S ALREADY BEEN INVESTIGATED IN THE LAB. IT DOESN'T WORK ON HUMANS.
ok show me the PDF and peer review
But that doesn't imply they're killed by a normal ph. Hell, they'd probably like it, as too acidic an environment is lethal to them as well.
Your red blood cells use anaerobic metabolism like a tumor. THEY don't die when you take bicarb.
So you haven't researched it whatsoever?
There have been a lot of therapies that tried to change the environment around a tumor. Mostly they don't work because your body's going to move whatever you're doing to the tumor into the rest of your body. Diathermy comes to mind.
It's been investigated and found not to be viable as it would end up killing you.
n contrast, NaHCO(3) therapy significantly reduced the formation of hepatic metastases following intrasplenic injection, suggesting that it did inhibit extravasation and colonization. I
originally posted by: frenchfries
a reply to: TerryDon79
n contrast, NaHCO(3) therapy significantly reduced the formation of hepatic metastases following intrasplenic injection, suggesting that it did inhibit extravasation and colonization. I
so... 'colonization inhibited' do I read this right ? Not a therapy but some effects.. thats why I coined PH is the key
the alkaline diet you speak of is well documented