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originally posted by: PhotonEffect
a reply to: peter vlar
Very cool stuff about the highlanders' ability to reside at such lofty elevations around the world. Even more interesting is the way they evolved convergently to withstand such extreme conditions.
I've been doing some research into the various mutations that gave way to these special traits. There is something intriguing about the timing of these mutations that will require a bit more research to flush out. Might be the topic of a forthcoming thread...
originally posted by: peter vlar
This study evaluates genetic and phenotypic variation in the Colla population living in the Argentinean Andes above 3500 m and compares it to the nearby lowland Wichí group in an attempt to pinpoint evolutionary mechanisms underlying adaptation to high altitude hypoxia. We genotyped 730,525 SNPs in 25 individuals from each population. In genome-wide scans of extended haplotype homozygosity Collas showed the strongest signal around VEGFB, which plays an essential role in the ischemic heart, and ELTD1, another gene crucial for heart development and prevention of cardiac hypertrophy. Moreover, pathway enrichment analysis showed an overrepresentation of pathways associated with cardiac morphology. Taken together, these findings suggest that Colla highlanders may have evolved a toolkit of adaptative mechanisms resulting in cardiac reinforcement, most likely to counteract the adverse effects of the permanently increased haematocrit and associated shear forces that characterise the Andean response to hypoxia. Regulation of cerebral vascular flow also appears to be part of the adaptive response in Collas. These findings are not only relevant to understand the evolution of hypoxia protection in high altitude populations but may also suggest new avenues for medical research into conditions where hypoxia constitutes a detrimental factor.
Colla Study
originally posted by: peter vlar
This is in stark contrast to people born with the EPAS1(along with roughly 10 more adapttive mutations) mutation from Tibet, Nepal and Northern India.
originally posted by: peter vlar
The other thing I find rather interesting is that both of these mutations appeared in roughly similar time frames on opposite sides of the globe.
originally posted by: cooperton
originally posted by: peter vlar
a reply to: Masterjaden
So what you're really saying is that it takes 6 paragraphs and a double post for you to say nothing and then demonstrate that you still don't understand what empirical evidence is in context of the scientific method. One does not have to millions or billions of years of first person witness in order to be empirical. When tests are done and those results are independantly repeated and corroborated, this too is empirical data. In the case of radiometric dating, this independant corroboration has been done on an international scale for 75+ years in some instances such as 14c dating which was first demonstrated in the late 40's.
With carbon-dating you can estimate to a certain degree the starting C-14 in the sample organism because we could make an assumption on past atmospheric C-14 levels based on what we observed today, although this still involves assumption
You love to claim its all assumption which I find perplexing. No dating method is ever the sole determinate when an age is given. his is especially true in the example of 14C dating. We have atmospheric records going back over 100 KA from ice core samples taken from multiple locations across the planet from Antarctica to Greenland to Canada, Alaska, Siberia etc... so to say its an assumption regarding 12C:14C rations is silly. Additionally, dendrochronology is used to calibrate and corroborate the efficacy of 14C dating.
But with Uranium-lead dating I see no clear empirical evidence that could determine initial lead concentration of the sample.
As I've tried to explain to you before, the starting ration of U 238b 206 is mind blowingly simple to understand. Lead 206 only exists as the end product of Uranium 238's decay. There are a total of 8 Alpha and 6 Beta decays between U 238 and its daughter nuclides and its final daughter, the isotope of Pb 206.
I simply don't understand why it is such a difficult concept to grasp that if Pb 206 can not exist until after this decay process, then the initial count is going to consist of U 238/100%- Pb 206/ 0%. If there is any Lead 206 in your sample then the sample is old enough to have undergone decay and the ratios can be determined thereby giving you an age, within its known margin of error of course. Nobody is saying that these dates are down to the exact year or month, especially when dealing with ages in the range of Billions of years.
Every date given, from any of the dozens of radiometric dating techniques, includes a margin of error. Even 14C dating. But to imply that everything is pure assumption and that there is no way to determine the initial rations of given isotopes within a sample makes me wonder if you are not reading any of the citations provided by Phantom423 or if you're just being obstinate for your own amusement.
originally posted by: Phantom423
originally posted by: cooperton
originally posted by: Phantom423
Coop, I gave you the entire explanation - in detail - in a previous post. Didn't you read it???????????????????
None of it addressed my concern - how are initial Lead-Uranium concentrations determined? I am not concerned with instruments and contemporary decay rates.
Then explain your concerns. What's the problem with the instrumentation? What's the problem with the calculations? To say you're "concerned" doesn't say much. Please explain.
originally posted by: cooperton
Rereading some of the posts, I think you may have misinterpreted Peter's explanation. He's absolutely correct - at time = zero for uranium there were no decay products i.e. lead - that's when uranium was formed in the galaxy, probably super novas. Uranium is of cosmic origin, not formed on this planet (at least to my knowledge). So at time zero for uranium, the decay byproducts were at zero concentration. After its formation, uranium begins to decay, then the decay products appear, ultimately resulting in lead.
You're asking about initial concentrations of uranium. Concentrations are irrelevant - whether it was one gram or one ton the half life calculation is the same. If that calculation was incorrect, there would be another element present today - and it wouldn't be the uranium byproducts that we observe i.e lead.
I think the misunderstanding goes to what half life really is. Half life is NOT dependent on concentration of a particular atom. It's only dependent on the energy difference of the reactants. For any element that is radiogenic, the kinetic energy (before) - kinetic energy (after) = the decay product. The difference can be measured and the result is the half life of that particular element. That solution applies to one atom or one hundred tons of the element. The starting concentration or quantity of the element is irrelevant. If the decay rate was different for uranium in the past, then we would have different element byproducts today - and it would NOT be the uranium byproducts that we observe - i.e. lead.
Where did uranium come from?Cosmochemists have been concerned not only with patterns and secular trends of abundance of the elements in galaxies but also with the origins of abundance anomalies in particular stars and with theories on the synthesis of different nuclei to account for these observations. According to the theories developed, the Earth's uranium was produced in one or more supernovae ("An explosive brightening of a star in which the energy radiated by it increases by a factor of ten billion ... A supernova explosion occurs when a star has burned up all its available nuclear fuel and the core collapses catastrophically." - Oxford Dictionary of Physics). The main process concerned was the rapid capture of neutrons on seed nuclei at rates greater than disintegration through radioactivity. The neutron fluxes required are believed to occur during the catastrophically explosive stellar events called supernovae. Gravitational compression of iron (the island of nuclear stability, incapable of further exothermic fusion reactions) and sudden collapse in the centre of a massive star triggers the explosive ejection of much of the star into space, together with a flood of neutrons. Remnants of hundreds of supernovae have been found, and we "witnessed" one in the Magellanic Clouds in 1987.So, we know that the Earth's uranium was produced through this process in one or more supernovae, and that this material was inherited by the solar system of which the Earth is a part.
www.world-nuclear.org...
edit on 23-10-2016 by Phantom423 because: (no reason given)edit on 23-10-2016 by Phantom423 because: (no reason given)edit on 23-10-2016 by Phantom423 because: (no reason given)
originally posted by: Phantom423
at time = zero for uranium there were no decay products i.e. lead - that's when uranium was formed in the galaxy, probably super novas. Uranium is of cosmic origin, not formed on this planet.
originally posted by: Phantom423
You're asking about initial concentrations of uranium. Concentrations are irrelevant
- whether it was one gram or one ton the half life calculation is the same.
originally posted by: cooperton
originally posted by: Phantom423
at time = zero for uranium there were no decay products i.e. lead - that's when uranium was formed in the galaxy, probably super novas. Uranium is of cosmic origin, not formed on this planet.
Which you would agree is an assumption right? There is no empirical evidence to prove such a claim.
originally posted by: cooperton
originally posted by: Phantom423
at time = zero for uranium there were no decay products i.e. lead - that's when uranium was formed in the galaxy, probably super novas. Uranium is of cosmic origin, not formed on this planet.
Which you would agree is an assumption right? There is no empirical evidence to prove such a claim.
originally posted by: Phantom423
There's no assumption here. If it were an assumption then nothing would "work" as we understand uranium - or any other element for that matter.
No they are very relevant. If you don't know the initial concentration how could you have a start point to compare the end sample?
originally posted by: Phantom423
a reply to: Phantom423
Again, I don't think you understand half life. Half life is about energy loss. It's about an atom, in this case uranium, losing some energy and producing another element. That's it. There's nothing complicated about it.
originally posted by: cooperton
originally posted by: Phantom423
There's no assumption here. If it were an assumption then nothing would "work" as we understand uranium - or any other element for that matter.
we know the decay rates because we can test it, I am not arguing that. we DONT know the initial concentrations of uranium-lead rock because we cannot observe such conditions. To say lead-206 ONLY comes from radioactive uranium is an assumption. To say there was no lead in the initial concentration is an assumption - if you can't accept that I don't see this conversation going anywhere.
originally posted by: cooperton
originally posted by: Phantom423
a reply to: Phantom423
Again, I don't think you understand half life. Half life is about energy loss. It's about an atom, in this case uranium, losing some energy and producing another element. That's it. There's nothing complicated about it.
Solve this puzzle:
A burning candle loses 1 inch of wax every minute, and is currently 12 inches tall. How long has the candle been burning?
Here we know the rate (i.e. half life) and the present measurement, yet without the initial measurement, we can never know how long the candle has been burning
originally posted by: Phantom423
Uranium at time = zero has no decay products.
originally posted by: Phantom423
No, no and no. That's an absolutely wrong analogy. The candle doesn't burn by itself - it doesn't lose energy as a consequence of its chemical composition. Someone lit the candle - this is an entirely different process.
originally posted by: cooperton
originally posted by: Phantom423
Uranium at time = zero has no decay products.
Is it not possible that the formation of uranium coincides with lead formation? How do you know uranium formation is 100% pure?
originally posted by: cooperton
originally posted by: Phantom423
Uranium at time = zero has no decay products.
Is it not possible that the formation of uranium coincides with lead formation? How do you know uranium formation is 100% pure?
originally posted by: cooperton
originally posted by: Phantom423
Coop, I gave you the entire explanation - in detail - in a previous post. Didn't you read it???????????????????
None of it addressed my concern - how are initial Lead-Uranium concentrations determined? I am not concerned with instruments and contemporary decay rates.
originally posted by: Phantom423
Concentrations are irrelevant - whether it was one gram or one ton the half life calculation is the same.
originally posted by: cooperton
originally posted by: Phantom423
Concentrations are irrelevant - whether it was one gram or one ton the half life calculation is the same.
Initial ratio of Uranium to Lead in the sample. How do we know the given sample of Uranium-lead contained no lead to begin with? I believe this is an assumption and would like to see a certain way to determine the original sample contained no lead. I know uranium atoms are uranium atoms, but the samples that are being tested contain both uranium and lead- how do they know the original sample contained no lead?
originally posted by: cooperton
originally posted by: Phantom423
Concentrations are irrelevant - whether it was one gram or one ton the half life calculation is the same.
Initial ratio of Uranium to Lead in the sample. How do we know the given sample of Uranium-lead contained no lead to begin with? I believe this is an assumption and would like to see a certain way to determine the original sample contained no lead. I know uranium atoms are uranium atoms, but the samples that are being tested contain both uranium and lead- how do they know the original sample contained no lead?