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London Fire Brigade (LFB) is battling a blaze in a Fleet Street building adjacent to the offices of Goldman Sachs.
Smoke engulfed the building at some point after 2.30pm GMT on Wednesday afternoon.
Some 30 firefighters and six fire engines are on the scene.
Reports suggest the fire is above the historic Ye Olde Cheshire Cheese, a long-time favorite watering hole of Fleet Street journalists.