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Simply run Autoruns and it shows you the currently configured auto-start applications as well as the full list of Registry and file system locations available for auto-start configuration. Autostart locations displayed by Autoruns include logon entries, Explorer add-ons, Internet Explorer add-ons including Browser Helper Objects (BHOs), Appinit DLLs, image hijacks, boot execute images, Winlogon notification DLLs, Windows Services and Winsock Layered Service Providers, media codecs, and more. Switch tabs to view autostarts from different categories.
In the top-right corner of the browser window, click the Chrome menu Chrome menu.
At the bottom, click Show advanced settings.
Under the section "Reset settings," click Reset settings.
In the dialogue that appears, click Reset.
originally posted by: spygeek
I use Firefox so when something hijacks my homepage I just go into about:config and remove it, there is surely a comparative feature in chrome.. Check your add-ons list too as some websites and programs install them without asking..