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the team had to first design and build a device that allowed for such manipulation—they call it AS-PaRac—it is an optoprobe that is capable of causing changes to spines that grow on the edges of dentrites, the listening or input part used by neurons to communicate with one another. Prior work has suggested that their tips grow bigger as part of storing a new memory.
Dendritic spines are the major loci of synaptic plasticity and are considered as possible structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of spines in the cortex has been unattainable, and thus, the link between spines and memory has been correlational. We developed a novel synaptic optoprobe, AS-PaRac1 (activated synapse targeting photoactivatable Rac1), that can label recently potentiated spines specifically, and induce the selective shrinkage of AS-PaRac1-containing spines. In vivo imaging of AS-PaRac1 revealed that a motor learning task induced substantial synaptic remodelling in a small subset of neurons. The acquired motor learning was disrupted by the optical shrinkage of the potentiated spines, whereas it was not affected by the identical manipulation of spines evoked by a distinct motor task in the same cortical region. Taken together, our results demonstrate that a newly acquired motor skill depends on the formation of a task-specific dense synaptic ensemble.
originally posted by: chr0naut
a reply to: stormbringer1701
I read the article that you linked to and then played the video at the end.
What were we talking about?
originally posted by: Tranceopticalinclined
a reply to: chr0naut
They've been able to send a beam of light into the spine of mice and cause them to forget learned memories.
originally posted by: Bedlam
originally posted by: Tranceopticalinclined
a reply to: chr0naut
They've been able to send a beam of light into the spine of mice and cause them to forget learned memories.
Well, not really.
This has been threaded to death a few times already. What is going on is that they have to virally modify the neurons to react to the light. Then they insert a fiber optic probe into the mice's hippocampal area, and use a laser to modify the individual neurons in the hippocampus.
The happy mice you see in the article's picture are not what you see in the lab. THOSE mice have ports in their skulls with fiber connections permanently inserted.
And the spines they're talking about aren't down the back of the mice, it's a microscopic structure on the neuronal dendrites in the hippocampus.
So it has light involved, but it's not like it's a flashy thing, it's a pile of lab equipment used on a critter that's been genetically modified and has a fiber optic tap on its head.
originally posted by: ProleUK
A few bottles cheap red wine do the same to me.
I've lost count waking up with a hangover, no pants and shoes, no recollection what so ever. Memory gone, wiped.
originally posted by: chr0naut
originally posted by: ProleUK
A few bottles cheap red wine do the same to me.
I've lost count waking up with a hangover, no pants and shoes, no recollection what so ever. Memory gone, wiped.
Perhaps you are just a clone with implanted memories and the real 'you' died from alcohol poisoning or a stupid accident, ruining 'their' experiment. So they substituted one of their back-up clones.
You should check your body for absence of scars, differences in freckles and moles and such. Then you could be sure.
(kidding)
originally posted by: Flanker86
In particular the EU uses this techniques to prevent citizens from learning a foreign language, as newly learned terminology, vocabulary and grammar rules can be erased from your brain.
1 year, to reach a C1 level is possible with these technology!
originally posted by: GetHyped
originally posted by: Flanker86In particular the EU uses this techniques to prevent citizens from learning a foreign language
Most Europeans are multilingual.