It looks like you're using an Ad Blocker.
Please white-list or disable AboveTopSecret.com in your ad-blocking tool.
Some features of ATS will be disabled while you continue to use an ad-blocker.
B cell lymphoma was positively associated with phenoxy herbicides and the organophosphorus herbicide glyphosate
Eli Lilly acquired rBGH, sold as Posilac, from biotech company Monsanto in 2008, despite the bad publicity Monsanto received for years for developing the hormone
Mitch Daniels, Director of the Office of Management and Budget, was the vice president of another company that developed the hormone (rBGH) with Monsanto, Eli Lilly.
In 2002, Pfizer merged with Pharmacia. The merger was again driven in part by the desire to acquire full rights to a product, this time Celebrex (celecoxib), the COX-2 selective inhibitor previously jointly marketed by Searle (acquired by Pharmacia) and Pfizer. In the ensuing years, Pfizer commenced with a massive restructuring resulting in numerous site closures and loss of jobs including: Terre Haute, IN; Holland, MI; Groton, CT; Brooklyn, NY; Sandwich, UK and Puerto Rico.
Pharmacia had been formed by a series of mergers and acquisition with its predecessors, including Searle, Upjohn and Sugen.
Searle was founded in Omaha, Nebraska, in April 1888. The founder was Gideon Daniel Searle. In 1908, the company was incorporated in Chicago. In 1941, the company established headquarters in Skokie, Illinois. It was acquired by the Monsanto Company, headquartered in St. Louis, in 1985.
Fig 1 age-dependent decline in serum testosterone in America
In America, there has been a substantial age-independent decline in testosterone that does not appear attributable to observed changes in explanatory factors including health status and lifestyle characteristics such as smoking and obesity. The estimated declines were larger than the cross sectional declines typically associated with age, as shown in Figure 1 .
Congenital malformations of the male reproductive tract – undescended testis and incomplete fusion of the urethral folds that form the penis – are among the most frequent congenital malformations in human males. These two abnormalities share common risk factors, both associated with reduced fertility; the first malformation is also associated with poor semen quality and considerably increased risk of TGC. Incidences of these malformations appear to have been increasing in the Western world over recent decades.
Testosterone, the male hormone, is the major driver of male reproductive development and function. Suppression of its levels within the adult testis shuts down spermatogenesis and induces infertility. Studies of men with idiopathic infertility – for which the cause is unknown - and low sperm counts often show evidence of abnormal Leydig cells, which produce testosterone in the testis.
In Europe, incidences of TGC and congenital reproductive tract malformations have been going up coincidentally with a downward trend in semen quality and testosterone levels (although there are only data for the latter in Denmark). These disorders share common risk factors and are risk factors for one another. Consequently, it has been proposed that the conditions collectively may represent a syndrome - a testicular dysgenesis syndrome (TDS) - caused by a common underlying causal factor, which is either a change in lifestyle or an environmental toxin, especially endocrine disrupting chemicals such as pesticides. Notably, the review published by the European Science Foundation (an official body that coordinates international research programmes in Europe) fails to mention glyphosate explicitly, even though its use has been rising most rapidly among pesticides in Europe and in the rest of the world since the 1980s to 1990s.
April 25 (Reuters) - Heavy use of the world's most popular herbicide, Roundup, could be linked to a range of health problems and diseases, including Parkinson's, infertility and cancers, according to a new study.
The peer-reviewed report, published last week in the scientific journal Entropy, said evidence indicates that residues of "glyphosate," the chief ingredient in Roundup weed killer, which is sprayed over millions of acres of crops, has been found in food.
Those residues enhance the damaging effects of other food-borne chemical residues and toxins in the environment to disrupt normal body functions and induce disease, according to the report, authored by Stephanie Seneff, a research scientist at the Massachusetts Institute of Technology, and Anthony Samsel, a retired science consultant from Arthur D. Little, Inc. Samsel is a former private environmental government contractor as well as a member of the Union of Concerned Scientists.
"Negative impact on the body is insidious and manifests slowly over time as inflammation damages cellular systems throughout the body," the study says. We "have hit upon something very important that needs to be taken seriously and further investigated," Seneff said.
Environmentalists, consumer groups and plant scientists from several countries have warned that heavy use of glyphosate is causing problems for plants, people and animals.
Free Radic Biol Med. 2013 Dec;65:335-46. doi: 10.1016/j.freeradbiomed.2013.06.043. Epub 2013 Jun 29.
Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells.
de Liz Oliveira Cavalli VL1, Cattani D, Heinz Rieg CE, Pierozan P, Zanatta L, Benedetti Parisotto E, Wilhelm Filho D, Mena Barreto Silva FR, Pessoa-Pureur R, Zamoner A.
edit on 20-3-2015 by StoutBroux because: (no reason given)
Glyphosate is the primary active constituent of the commercial pesticide Roundup. The present results show that acute Roundup exposure at low doses (36 ppm, 0.036 g/L) for 30 min induces oxidative stress and activates multiple stress-response pathways leading to Sertoli cell death in prepubertal rat testis. The pesticide increased intracellular Ca(2+) concentration by opening L-type voltage-dependent Ca(2+) channels as well as endoplasmic reticulum IP3 and ryanodine receptors, leading to Ca(2+) overload within the cells, which set off oxidative stress and necrotic cell death. Similarly, 30 min incubation of testis with glyphosate alone (36 ppm) also increased (45)Ca(2+) uptake.
Glyphosate has been described as an endocrine disruptor affecting the male reproductive system
“Contrary to the current widely-held misconception that glyphosate is relatively harmless to humans, the available evidence shows that glyphosate may rather be the most important factor in the development of multiple chronic diseases and conditions that have become prevalent in Westernized societies.” [emphasis added]