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www.ncbi.nlm.nih.gov...
Stress and the inflammatory response: a review of neurogenic inflammation.
The subject of neuroinflammation is reviewed. In response to psychological stress or certain physical stressors, an inflammatory process may occur by release of neuropeptides, especially Substance P (SP), or other inflammatory mediators, from sensory nerves and the activation of mast cells or other inflammatory cells. Central neuropeptides, particularly corticosteroid releasing factor (CRF), and perhaps SP as well, initiate a systemic stress response by activation of neuroendocrinological pathways such as the sympathetic nervous system, hypothalamic pituitary axis, and the renin angiotensin system, with the release of the stress hormones (i.e., catecholamines, corticosteroids, growth hormone, glucagons, and renin). These, together with cytokines induced by stress, initiate the acute phase response (APR) and the induction of acute phase proteins, essential mediators of inflammation. Central nervous system norepinephrine may also induce the APR perhaps by macrophage activation and cytokine release
Mechanism of the vasodilator action of calcitonin gene-related peptide in conscious rats.
www.ncbi.nlm.nih.gov...
Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin.
The amino acid glutamate—and its receptor and signalling functions— is fast becoming the one to watch with autism spectrum disorders in mind.
jp.physoc.org...
The specific role of the neuromodulator substance P (SP) and its target, the neurokinin 1 receptor (NK1R), in the generation and regulation of respiratory activity is not known. The preBötzinger complex (preBötC), an essential site for respiratory rhythm generation, contains glutamatergic NK1R-expressing neurones that are strongly modulated by exogenously applied SP or acute pharmacological blockade of NK1Rs. We investigated the effects of capsaicin, which depletes neuropeptides (including SP) and glutamate from presynaptic terminals, on respiratory motor output in medullary slice preparations of neonatal rat that generate respiratory-related activity.
pubchem capsaicin
The Danger of MSG and How it is Hidden in Vaccines
American prosecutors are attempting to extradite a Danish scientist.
Poul Thorsen has been charged with 13 counts of wire fraud and nine counts of money laundering; a federal grand jury alleges that Thorsen stole over $1 million from autism research funding between February 2004 and June 2008.
Thorsen is said to have used the proceeds to buy a home in Atlanta, two cars and a Harley Davidson. He is said to have stolen the money while serving as the 'principal investigator' for a program that studied the relationship between autism and exposure to vaccines.
The Copenhagen Post reports:
"... [O]ver the four-year period he submitted over a dozen false invoices from the CDC for research expenses to Aarhus University, where he held a faculty position, instructing them to transfer the funds to a CDC account, which was in fact his personal account ...
Thorsen's research on autism is widely known in academic circles, where he was until this week a highly respected figure. A paper of his on the subject, which is known as 'The Danish Study', is quoted extensively to refute the autism vaccine connection."
When two of the biggest names in vaccine research and support turn out to be guilty of fraud, major deception, lying and making unsubstantiated statements, it really calls into question the validity of their work on the vaccine front … and that's putting it mildly.
Yet, this news has only been quietly shared by a handful of media outlets.
Countless American parents are putting their trust, and their child's lives, in the hands of the U.S. Centers of Disease Control and Prevention (CDC) and the American Academy of Pediatrics (AAP) every time they vaccinate their children. Yet two of the CDC's "go-to guys" have now been caught red-handed lying and, in the case of Dr. Poul Thorsen, committing outright fraud. This includes:
Dr. Poul Thorsen, who was involved in several key studies the CDC uses to support their claims that MMR and mercury-containing vaccines, among others, are safe.
Dr. Paul Offit, a very well-known and frequent proponent of mandatory vaccination, whose views are promoted by the AAP and who previously served as a member of The Advisory Committee on Immunization Practices (ACIP). ACIP is a 15-member panel of immunization experts, selected by the Secretary of the U.S. Department of Health and Human Services. They provide advice and guidelines to the CDC on vaccine-preventable diseases.
That’s why we have real science. The Scientific Opinion on the re-evaluation of aspartame (E 951) as a food additive (pdf), published by the European Food Safety Authority (EFSA), came to the following scientific consensus:
The amount of aspartame that is absorbed into the bloodstream is nonexistent in numerous human and animal studies. This supports the understanding that aspartame is hydrolyzed into its simple, and widely consumed, constituent components in the digestive tract.
Scientists have found no acute toxic effects of aspartame.
The available data did not indicate that aspartame had any genotoxic effect.
There were no aspartame-related increases in neoplasms and tumors in carcinogenecity studies.
They did recognize some studies indicated that aspartame should not be consumed in large quantities by pregnant women, not necessarily because of the aspartame itself, but possibly because of gastrointestinal disturbances and quality of overall diet. They established that the potentially harmful dose of aspartame is 1000 mg/kg/day, a few hundred cans of diet soda per day.
They noted that there was no epidemiological evidence for potential associations between consumption of aspartame and cancers.
A large prospective cohort study in Denmark found no consistent association between the consumption of artificially sweetened beverages (but not with aspartame specifically) during pregnancy and the diagnosis of asthma or allergic rhinitis in children.
Data did not support genotoxicity of the methanol metabolite of aspartame.
Aluminum is added to vaccines to help the vaccine work more effectively [20], but unlike dietary aluminum which will usually clear rapidly from the body, aluminum used in vaccines and injected is designed to provide a long-lasting cellular exposure [18, 19]. Thus, the problem with vaccine derived aluminum is really twofold: It drives the immune response even in the absence of a viral or bacterial threat and it can make its way into the central nervous system. The origin of aluminum salts in vaccines has a curious, and largely unknown, history: In the early part of the twentieth century, vaccine researchers frustrated by low antibody titers in experimental vaccines added various compounds in the hope of making the vaccines more effective. In 1926, Glenney et al. [21] first experimented using aluminum salts as ‘‘helpers,’’ hence the term adjuvant. Aluminum worked so well at increasing antibody titers that it became the primary vaccine adjuvant in use, a circumstance which has continued to the present day. Unfortunately, the potential for aluminum to be harmful to various organ systems, including the central nervous system, does not appear to have been rigorously tested [19].
Danbones
reply to post by InverseLookingGlass
very interesting
and of course as is mentioned above the vaccines result of low glutethione is to impair the body's ability to clear the toxic metal out
edit on Wedpm4b20144America/Chicago44 by Danbones because: (no reason given)
rickymouse
Danbones
reply to post by InverseLookingGlass
very interesting
and of course as is mentioned above the vaccines result of low glutethione is to impair the body's ability to clear the toxic metal out
edit on Wedpm4b20144America/Chicago44 by Danbones because: (no reason given)
Interesting.
From an article listed on Wikki. "Calcitriol (1,25-dihydroxyvitamin D3), the active metabolite of vitamin D3, after being synthesized from calcifediol in the kidney, increases glutathione levels in the brain and appears to be a catalyst for glutathione production.[29] Calcitriol was found to increase GSH levels in rat astrocyte primary cultures on average by 42%, increasing protein concentrations from 29 nmol/mg to 41 nmol/mg, 24 and 48 hours after administration; this effect was reduced to 11%, relative to the control, 96 hours after administration.[30] It takes about ten days for the body to process vitamin D3 into calcitriol.[31] Source: en.wikipedia.org...
Now, the potato is cursed for it's content of calcitriol, a potent hormone. It can cause calcification of the tissues if you eat too many potatoes without appropriate amounts of bioavailable vitamin K...or just add butter. Now there are a few bad effects to potatoes but this appears to have both positive and negative effects that should be considered.
Capsaicin is a nightinshade chemical.edit on 9-4-2014 by rickymouse because: (no reason given)
Treatment of arthritis with topical capsaicin: a double-blind trial.
articles.mercola.com...
Inflammation controls our lives. Have you or a loved one dealt with pain, obesity, ADD/ADHD, peripheral neuropathy, diabetes, heart disease, stroke, migraines, thyroid issues, dental issues, or cancer?
If you answered yes to any of these disorders you are dealing with inflammation.
Sadly, most of us are suffering from one or more of these disorders but have no idea how to eliminate inflammation. Most doctors are utilizing pharmaceuticals in lieu of getting to the root cause.
It often seems extremely foreign to most people when they realize the majority of inflammatory diseases start in the gut with an autoimmune reaction which progresses into systemic inflammation. To truly be effective at managing or hopefully overcome a disease it needs to be addressed on all levels. Taking a look at where this process starts is the key.
Autism is a complex neurological disorder characterized by severely impaired social interaction and language skills. The social and economic costs of the autism epidemic are staggering. In 2003, the Autism Society of America estimated the cost of treating the 1.5 million cases of autism to be $90 billion per year rising to $200-400 billion by 2010 (ASA 2003). In addition to the economic costs of treatment, autism is a tremendous burden to family members who must provide lifelong care to loved ones affected by the disorder.