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Histamine intolerance is defined by an imbalance of histamine and the histamine degrading enzyme diamine oxidase (DAO), which is mainly produced in the small intestine.
The typical symptoms of histamine intolerance are headache, diarrhea, migraine, engorged or dripping nose and especially in connection with food incorporation asthma and arrhythmia,
hypotension, urticaria and dysmenorrhoea. Those with anaphylactic reactions often also have lower histamine activity. The diagnosis of histamine intolerance is achieved by determination of the diamine oxidase activity in serum.
The proteolytic enzyme bromelain, derived from pineapple stems, is often formulated with the bioflavanoid quercetin. Bromelain-quercetin combinations are able to inhibit the release of histamines from mast cells found in connective tissues. Histamines cause tissues to swell, and account for the congestion associated with colds and sinus problems. Why not use antihistamine drugs? Anti-histamine drugs affect histamine receptors, and because of that, have well-established side-effects such as drowsiness. But bromelain-quercetin combinations don’t work through the histamine receptors and therefore don’t cause those side-effects. Their most significant side-effect of bromelain-quercetin is sexual in nature. Because histamines are essential to arousal and orgasm, some users may experience diminished sexual responsiveness when using bromelain-quercetin supplements.
Red wine happens to be of the things I simply cannot tolerate. Literally within seconds of taking my first sip, I get painful cramping in both my arms. If I keep drinking it, the pain will rapidly move into my chest, and then my whole body. I thought it was the sulfites all this time, but it might well be the histamines! The pain in my arms alone was enough to make me avoid red wine all of my life. All alcohol contains histamines, but red wine is the leader.