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Prions used to worry me until I ...found that they are pretty everywhere. ...Rolling the dice every-time I eat and it just isn't prions.
I happen to believe that autism is an evolutionary adaptation. Could prions be the cause of autism?
There is a kind of symmetry in the idea that the 'building blocks' of life, might also be the 'agents' of death.
reply to post by crazyewok
It pretty established that ill health can mess with brain chemistry and imduce changes.
Uh huh. And any idea exactly what mechanism might be responsible for those brain chemistry changes?
...toxins ..., drugs... and ...chems
reply to post by crazyewok
...toxins ..., drugs... and ...chems
You have listed the initiating factors aka epigenetic triggers - but NOT the molecular mechanism. To rephrase - how do the toxins, drugs and chemicals work? What do they do? What molecules do they affect and how do they affect them?
Animals sent to slaughter that are too sick to stand are killed and used for dog-food or sent to fertilizer plant.
Whatever it is that causes protein mal-rotation and prion formation gets recirculated. ...I am a bit surprised that plants contain prion protein.
This individual here thinks this is just the natural order of things??? WOW!!! REALLY???
Patrick Durkin: CWD puzzle only getting harder to put together
Consider the stakes: If state and federal agencies think it prudent to tell hunters to destroy prion-contaminated venison, will they soon warn everyone about prion-tainted plants? For that matter, will they stop farmers from buying, selling and transporting hay bales out of our CWD zone? …
And what about backyard gardens, morel mushrooms, wild raspberries and feed-grains growing in that ever-expanding CWD zone? Should we assume they’re prion-free? And if Great Britain and other countries won’t import U.S. animal feeds containing CWD-exposed meat byproducts, will they next ban plant-based feeds?
Granted, it’s silly to suggest raiding farmers markets and roadside stands that sell foods grown in CWD areas. We simply don’t know enough to risk another CWD panic.
But this much is certain: As we’ve slowly assembled the CWD puzzle piece by piece since 2002, the picture has only grown uglier. Meanwhile, lawmakers worked harder to stop research for more puzzle pieces than they did to control our deer herd, CWD’s undisputed chief carrier.
Their negligence might doom them yet.
The truth is it scares me. The bbc reported today that twice as many people in the uk who have been infected than first thought. They are saying 1 in 2000.
CSU Conference Highlights Mysteries of Prion Diseases and Ties to Human Neurological Disorders
What does chronic wasting disease [CWD] – a killer neurological disease in deer, elk, and moose – have in common with human brain disorders, such as Alzheimer’s and Parkinson’s disease?
The diseases are caused by protein misfolding that starts a degenerative chain reaction in the nervous system, ultimately leading to death. ...
Prusiner, a neurologist and biochemist, won the Nobel Prize in Physiology or Medicine in 1997 for prion research. He is credited with first proposing that misfolded proteins with infectious properties cause the family of degenerative neurological diseases now known as prion diseases, or transmissible spongiform encephalopathies. …
…CWD has spread from its epicenter in northern Colorado to at least 20 other states, two Canadian provinces, and South Korea, scientific surveillance has found.
“This is an emerging epidemic,” Telling said. “CWD is the only recognized prion disease in wild animals, which means it’s very difficult to control, and it’s extremely contagious. It’s important that we understand prion diseases so we can better assess risk to public health.”
Researchers estimate 1 in 2,000 people in the UK carry variant CJD proteins
The survey provides the most robust prevalence measure to date - and identifies abnormal prion protein across a wider age group than found previously and in all genotypes.
An accompanying editorial says that although the disease remains rare, "infection" may be relatively common and doctors need to understand the public health measures that are in place to protect patients.
Variant Creutzfeldt-Jakob disease (vCJD) is a degenerative brain disease – often called the human form of bovine spongiform encephalopathy (BSE) or "mad cow disease." It emerged after widespread exposure to BSE prions in the late 1980s and early 1990s through contaminated meat products in the food chain.
30,000 may carry human form of mad cow
...the peak of the human form of mad cow disease occurred in 2000. This suggests there is an 8-year incubation period for the disease. However, his research has revealed that there are at least three different forms of the prion protein linked to vCJD, which might explain why more people haven't become sick with the disease - yet.
"These people may harbor that [vCJD] for a longer time; they may develop a different type of prion disease; they may be silent carriers," says Brandner.
He says there's one definite concern: that these silent carriers may be potentially transmitting the disease.
Chronic wasting disease: forgotten, but not gone
As an environmental journalist, I know full well how difficult it can be to get people interested in a creeping problem. ...
...CWD takes years to kill a single infected individual and has yet to completely decimate an entire herd. “I’ve heard it called an epidemic in slow motion,”
...prions persist for years in the environment, says Johnson. They build up, and even amplify, in soil, infecting deer, elk and moose as they graze, and may even be taken up by the plants themselves. They linger in the feces and bodily fluids of infected animals and inside their carcasses after they die. ...
...Why are people less concerned about CWD now, when it’s clear that infection rates are rising? “Cause they’re not reading about it in the newspaper every day,” says Michael Miller, senior wildlife veterinarian with Colorado Parks and Wildlife. “Part of the problem, to be quite honest, is we know it’s there, we kind of have this nagging suspicion that it’s having some effect, but it’s been really hard to point to something clear. And we really don’t have a lot we can do about it.”
..."There is no place where this disease has ever occurred that it has been stopped," said Walt Cottrell, a veterinarian for the Pennsylvania Game Commission. "There are two things the disease does when it arrives: It gets worse, and it spreads."
And, eventually, it fades into the background, like so many other creeping environmental problems.