Originally posted by ForwardDrift
Interesting find--hopefully the CD47 protein won't mutate in a way that prevents it from being recognized by the antibodies, yet still retain immunity. Either way, this is an astounding breakthrough, and I can't wait to see the range and extent of the drug. I do have one concern about the antibody: what prevents the CD47 antibody from recognizing the CD47 protein markers on healthy cells other than by mere difference in ratio of CD47s in cancer cells to healthy cells? Would this antibody induce the immune system to attack healthy cells after the cancer cells with CD47 are gone? Anyway, great post.
edit on 4-4-2013 by ForwardDrift because: (no reason given)edit on 4-4-2013 by ForwardDrift because: (no reason given)
For the last year, many people have been working to make clinical trials possible. We are now hopeful that the first human clinical trials of anti-CD47 antibody will take place at Stanford in mid-2014, if all goes well. Clinical trials may also be done in the United Kingdom.
Originally posted by ShortStuff
You're right, this will never get to see the light of day. The pharmaceutical companies would go out of business, and they won't let that happen.
Originally posted by novrod
I went to a science meeting in Zurich / Switzerland a couple of months ago and I have been in contact with some of the scientists involved in the clinical trials of CD47.
I am sorry to say that CD47 is "just" another piece of the puzzle. Do not take me wrong, it will save many lives but it is still not the definitive cure. The current research projects are trying to find and validate other important molecules involved in this process.
As far as I can tell, and I am cancer research scientist, we are getting better but CD47 is still not the final answer. The magic bullet that only targets the cancer cells but not the healthy ones is still not known. The problem is that tumors are quite heterogeneous. Many things were tried but much more must be discovered.
Originally posted by PhoenixOD
reply to post by ForwardDrift
have you watched the video i just posted?