A cordon has been put in place in the city centre after police received reports of a suspicious package.
Police were called to New York Street at 7.35am to reports of a suspicious package having been left near to the Mecure Manchester Piccadilly hotel.
A cordon has been put in place and a number of roads are shut while the incident is dealt with.
The incident is likely to affect some bus and tram journeys and motorists and commuters are advised to avoid the area.
A 100 metre cordon has been put in place and bomb disposal experts are en route.