Somewhere in Florida, 25,000 disembodied rat neurons are thinking about flying an F-22.

These neurons are growing on top of a multi-electrode array and form a living "brain" that's hooked up to a flight simulator on a desktop computer. When information on the simulated aircraft's horizontal and vertical movements are fed into the brain by stimulating the electrodes, the neurons fire away in patterns that are then used to control its "body" -- the simulated aircraft.
WIRED News

GAINESVILLE, Fla. --- A University of Florida scientist has grown a living “brain” that can fly a simulated plane, giving scientists a novel way to observe how brain cells function as a network.

The “brain” -- a collection of 25,000 living neurons, or nerve cells, taken from a rat’s brain and cultured inside a glass dish -- gives scientists a unique real-time window into the brain at the cellular level. By watching the brain cells interact, scientists hope to understand what causes neural disorders such as epilepsy and to determine noninvasive ways to intervene.

As living computers, they may someday be used to fly small unmanned airplanes or handle tasks that are dangerous for humans, such as search-and-rescue missions or bomb damage assessments.

“We’re interested in studying how brains compute,” said Thomas DeMarse, the UF professor of biomedical engineering who designed the study. “If you think about your brain, and learning and the memory process, I can ask you questions about when you were 5 years old and you can retrieve information. That’s a tremendous capacity for memory. In fact, you perform fairly simple tasks that you would think a computer would easily be able to accomplish, but in fact it can’t.”
University of Florida