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Originally posted by Maxmars
By using the fragment and generating particles mimicking a virus in structure, the immune system can learn to recognize any type of flu virus and attack the pathogen, preventing illness. The research appears in a recent edition of the journal Molecular Therapy, published by the Nature Publishing Group.
"We can now design a vaccine that makes it easier to induce a good immune system response to recognize a pathogen, regardless of how the surface proteins of the virus change," Kang said.
At first, the idea of genetically synthesizing a "signature" virus for immunization seemd a bit frightening to me... then I read further and became truly concerned....
Here's a snippet of the abstract of the research.... I have highlighted some portions that I think bear scrutiny... I am hoping the ATS members will help me accept, reject, or understand more fully what this report indicates:
From: Molecular Therapy, 2012; DOI: 10.1038/MT.2012.246
The extracellular domain of M2 (M2e), a small ion channel membrane protein, is well conserved among different human influenza A virus strains.
To improve the protective efficacy of M2e vaccines, we genetically engineered a tandem repeat of M2e epitope sequences (M2e5x) of human, swine, and avian origin influenza A viruses, which was expressed in a membrane-anchored form and incorporated in virus-like particles (VLPs). ...
Intramuscular immunization with M2e5x VLP vaccines was highly effective in inducing M2e-specific antibodies reactive to different influenza viruses, mucosal and systemic immune responses, and cross-protection regardless of influenza virus subtypes in the absence of adjuvant.
Thus, molecular designing and presenting M2e immunogens on VLPs provide a promising platform for developing universal influenza vaccines without using adjuvants.
Well, we know the industry has been fighting against those who identify the adjuvants as part of the problem with vaccines... perhaps this is a solution?
But combining these viral particle signatures and inducing a response in the immune system might not be a cut and dry as it expresses itself int he lab.... or under clinical controls.
"Universal vaccine" may be the next pharmaceutical hurtle the human condition will have to overcome... unless the science is sound... and the genetically-designed VLPs are benign....
What say you?
(visit the link for the full news article)
Originally posted by FissionSurplus
Maybe I've become incredibly jaded, but I simply do not trust the newer biomedical technologies. They often find one little piece of the puzzle, and then are surprised when things go totally haywire because they didn't see the other parts and how they all fit together.
They should be working to strengthen our immune systems to work more effectively against whatever it comes up against. But that wouldn't be very profitable, would it?
Thanks to the polio vaccine push in the 50s and 60s, all us baby boomers were injected with Simian Virus 40, as the vaccines were grown on green monkey kidneys that had this virus. Now we're all dropping like flies from cancer. See what I mean? They see one part, and fail to see the whole.
Gonna pass on this one, thanks but no thanks. If other people want to be guinea pigs, they can be my guest.