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The Church of HIV: Inventing the AIDS Virus

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posted on May, 24 2012 @ 08:54 PM
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reply to post by Maslo
 


Continuing with: Toxic Hope : Widely Embraced, The Aids Drug Is Now Under Heavy Fire. : The Azt Story


Everyone expected to rubber-stamp this. After all, this was Burroughs Wellcome. Their drug applications were always clean and thorough--no discrepancies or anomalies. By the time a drug had overcome all the regulatory hurdles to reach this stage of the approval process--and only 20% do--it was usually ready to be marketed. Itzak Brook, who chaired the FDA panel, had even alerted the agency's public-affairs officer to prepare a press release.

Brook, a spare man with delicate features, is a professor of pediatrics and surgery at the Uniformed Services University of the Health Sciences in nearby Bethesda. He had chaired the FDA's Anti-Infective Drug Advisory Committee for two years. But he had never seen anything quite like this. There wasn't an empty seat in the large room. AIDS activists were patrolling the grounds and buttonholing panelists whey they went to the bathroom, pressuring them to approve the drug. Brook and the 10 other members of the approval panel felt a tremendous burden of responsibility to do the right thing.

But as the morning wore on, Brook became increasingly uneasy. According to the testimony given that day, more patients in the AZT group had died since the study was halted. And the many blood transfusions given to patients on AZT could have accounted for the difference in survival rates.


The next two paragraphs are as follows:


The FDA's anti-viral chief, Ellen Cooper, a cool professional, was sharply critical of the study during her testimony. She had little more than a month to review the data--normally FDA medical officers have several months to digest this information and do a meaningful analysis--but what she found was troubling. The study had been unblinded, leaving open the possibility of biases in patient management. It alarmed her that long-term toxicity studies on animals weren't completed, so there was no telling what the consequences of AZT would be in humans over time. "Will efficacy last? Will toxicity accumulate to intolerable levels with longer exposure? Prolonged administration of an anti-retroviral agent, such as AZT, may be of more harm than benefit, she concluded. To approve this drug would represent a "significant and potentially dangerous departure from our normal toxicology requirements.

Perhaps the initial results were a statistical fluke, Brook thought. Perhaps the study was stopped prematurely. At the lunch break, he discovered other panelists shared his misgivings, agreeing that they needed more data. After lunch, Brook recalls, the FDA brought in the heavy artillery.


What I have just quoted beginning in the above post and now this post is just one page of this story. The articles actually begins as such:


It was such a shocking incident that it seemed to unfold in slow motion. Researcher Peter Mansell, normally cerebral and brooding, was almost jovial as he reeled off figures from a nationwide test of ribavirin, a drug to combat AIDS. A ripple of excitement swept through the capacity crowd gathered in an unremarkable meeting room in the Washington Hilton hotel for the third International Conference on AIDS in June, 1987.

Mansell's presentation of dull scientific data didn't obscure his underlying message: ribavirin worked. HIV patients who took the drug were less likely to develop AIDS than those who didn't. "Dr. Mansell, a man shouted from the back of the room. "Do you or any of the other researchers have a financial interest in the approval of this drug of the company that makes it?

The audience erupted. Mansell, a veteran cancer researcher at M.D. Anderson Hospital in Houston, had a spotless reputation. The implication that he, or any of the scientists conducting the study, had acted unethically was outrageous.

Suddenly, another man jumped up on the podium and grabbed the microphone, a larger-than-life blur in the blinding dress whites of the U.S. Public Health Service. "Frank Young, FDA, he said, identifying himself as the commissioner of the Food and Drug Administration. Young told the stunned crowd that the FDA thought the ribavirin study was biased, perhaps even fraudulent, and that the Securities and Exchange Commission suspected ICN Pharmaceuticals, the Costa Mesa, Calif., company that made the drug, had used bogus test results to artificially inflate the price of its stock.


And the story continues...




posted on May, 24 2012 @ 08:54 PM
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Toxic Hope : Widely Embraced, The Aids Drug Is Now Under Heavy Fire. : The Azt Story Continues:


"It was like God coming down, recalls Peter Heseltine, who tested ribavirin at USC. He could not remember ever witnessing a government official publicly humiliating a respected researcher.

Subsequently, the FDA and the SEC launched separate investigations, raiding researchers' offices and confiscating file cabinets full of documents. Months later, they issued similar verdicts. Everyone was exonerated: The test data was deemed accurate, and no stock manipulation had occurred.

The affair still pains Heseltine, now director of the HIV clinic at Los Angeles County-USC Medical Center, where one-third of the county's AIDS patients are treated. "The humiliation fades, he says. "But the guys who literally gave their lives to do these studies and test ribavirin, the fact that their sacrifice was wasted, that's sticks with me. This was a potentially useful drug, but it was never given a chance.


At this point, I would like to take a break from that L.A. Times article to address what Wikipedia has to say about ribavirin in regards to HIV:


n Mexico, oral ribavirin has been available since the 1980s as an over-the-counter drug ("ribavirina," ICN pharmaceuticals Spanish tradename Vilona), for treating influenza. In this form it was occasionally brought into the U.S. for HIV/AIDS patients. However, ribavirin has proven to have little if any clinical usefulness against HIV, and it can greatly increase blood levels and also toxicity of the HIV antiviral didanosine (ddI, Videx). Other interactions with nucleoside antivirals for HIV should be considered when HIV/AIDS patients use ribavirin to treat hepatitis C (see "aidsinfo" external link).


Now back to that L.A. Times article:


A scant six months before the conference, scientists at the National Institutes of Health and officials at the FDA had lined up behind another drug, zidovudine, nicknamed AZT for its chemical components. AZT was a chemotherapy that had been sitting in an NIH shelf for 20 years because it was expensive and toxic to produce and didn't do much against cancer. But it had a rich producer with influential friends--Burroughs Wellcome, one of the pharmaceutical giants--and the enthusiastic backing of Dr. Samuel Broder, then associate director of the National Cancer Institute, one the behemoth research facilities that compose the NIH.

As with any war on disease, there is only so much money, only so many scientists. But in the mid-80's, AIDS activists were bringing intense pressure against the political and medical establishment, including candlelight vigils on the White House lawn and sit-down strikes at NIH headquarters. The medical community, desperate for something that would alleviate patients' suffering, began to focus almost all its resources on AZT. Nothing else, aside from two similarly designed chemotherapies, ddI and ddC, has been approved for use in combatting HIV since AZT was sanctioned by the FDA in 1987. Only today, six years later, is ribavirin--along with a few other AIDS drugs--finally being tested on humans.


A brief reminder that this article was published in 1993, and back to the story:


Until 1991, of the more than $420 million that has poured into the NIH's AIDS Clinical Trials Group, which conducts tests of experimental AIDS drugs in humans, 80% went toward studies on AZT. "We've lost many valuable years because of the sole preoccupation with AZT and its close relatives, ddC and ddI, says Michael Lange, an FDA adviser and assistant chief of infectious diseases at St. Luke's-Roosevelt Hospital in New York.

Now a new European study, the Concorde, casts doubts about whether AZT, which is used by 180,000 people worldwide and whose sales topped $385 million in 1992, should be taken by HIV-positive people who aren't yet ill. Some critics contend the drug may actually hasten the deterioration of the immune system associated with AIDS. In the post-mortems on AZT, some AIDS activists now admit that in their haste to get the drug approved, caution was swept aside.


Because this L.A. Times article is so well organized, and so well written I have felt compelled to quote much of it because of the context in which it puts AZT, its effectiveness, its toxicity, and why it was advocated as the primary source of funding and experimentation, and possibly why it is still advocated today in spite of its demonstrable toxicity.

That said, I will continue quoting parts of this L.A. Times story in the next post....



posted on May, 24 2012 @ 08:54 PM
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Toxic Hope : Widely Embraced, The Aids Drug Is Now Under Heavy Fire. : The Azt Story Continues:


With AIDS, an epidemic that blindsided the biomedical establishment, all these endemic problems were magnified. Scientists, desperate to conquer the disease that was sucking the life out of so many, jumped on the hypothesis that HIV was the lone AIDS assassin; they embraced AZT because it seemed to work by destroying some HIV when nothing else even came close. And because this disease hit a vocal and extraordinarily well-organized population, the scrutiny and political pressures have been intense.

But science is not always predictable. Scientific knowledge moves forward incrementally, with each new discovery built upon the bricks of the last. Many of the greatest breakthroughs--such as Alexander Fleming discovering the bacteria-fighting ability of penicillin after he saw mold forming in a petri dish in 1928--have been serendipitous. The likelihood of these fortuitous accidents increases if research is proceeding down many paths rather than intractably sticking to one road--which could be a dead end.

"I think we made a terrible mistake when we narrowed our focus, says Joseph Sonnabend, head of the Community Research Initiative on AIDS in New York, which conducts community-based tests of AIDS drugs. "Because if the role (of other factors besides HIV) had been worked out, then we might have come up with (other treatment) that could have helped people.


Linda Marsa, the author of this article, has done, I think, a marvelous job at attempting to offer a "fair and balanced" reporting:


Many dedicated AIDS researchers, however, have wearied of all this criticism from the sidelines. "There's a fascinating phenomenon here--there's a couple hundred people who are doing the studies and generating data, and a few thousand commentators, says Douglas Richman, a top AIDS researcher and a professor of pathology and medicine at UC San Diego. "These 'experts' all say the same thing--AZT was done too quickly, and drug development is going too slowly. We can't win. Still, progress has been incredibly fast. This virus was discovered less than 10 years ago, and we have three drugs approved and a whole bunch more that look promising.

"We're very proud of the speed with which we developed AZT, says Burroughs Wellcome spokesperson Kathy S. Bartlett. "Since 1985, we've supported more than 30 million clinical trials with AZT involving more than 20,000 patients. It's the most thoroughly studied antiretroviral medication there is. People need to remember a little bit what it was like back in 1985 and '86--how hard people worked to find a treatment for this disease. AZT certainly has its limitations, but it has made a big difference in people's lives.

Nonetheless, there is a consensus that politics shackled AIDS drug development. In the competitive world of AIDS research, dissent has often been stifled, and scientists who have challenged the twin pillars of AIDS research--that HIV is the sole cause of AIDS and that AZT is its only effective combatant--find it difficult to get grants. "It's a bit like the war on cancer in Nixon's time, observes Gunther Stend, former chairman of the molecular and cell biology department at UC Berkeley. "In some instances, people who couldn't hack it in other fields moved to AIDS, where they could get funding, and forced out the good scientists.


After fleshing out the story with more background on how drug companies have influenced the scientific process, and a bit of background on Burroughs Wellcome pharmaceuticals, Marsa writes:


In the early '80's, Burroughs Wellcome resynthesized AZT from a public-domain formula, saw that it prevented HIV from making an enzyme critical to its reproduction, and decided to throw its weight behind the drug. It was perhaps inevitable that AZT would become a pharmaceutical front-runner, but no one expected it to go unchallenged for so long. Some observers claim that most of the major pharmaceutical companies weren't initially interested in AIDS because the patient populations were too small to justify the research expense. Plus, viruses are wily foes--witness science's inability to conquer the common cold.

"AZT was seen as a temporary stopgap, says John James, editor of AIDS Treatment News. "Ideally, we should have gone on to fundamentally better drugs--which we have not done.


Finally we get into the study that is so sloppily referenced in Wikipedia as reported by the NIAID that ultimately leads us back to where I first began quoting this article. In the next post I will quote those preceding paragraphs...



posted on May, 24 2012 @ 08:54 PM
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Toxic Hope : Widely Embraced, The Aids Drug Is Now Under Heavy Fire. : The Azt Story Continues:


IN 1985, AFTER AZT SHOWED THAT IT was able to thwart HIV in test tubes, Burroughs Wellcome, with the blessing of the FDA, moved quickly to test the drug in people with AIDS. From the start, the tests were problematic. Patients were already desperately ill, and the drug seemed to make them even sicker. To be admitted to the tests, they had to have had pneumocystic carinii pneumonia, the No. 1 killer of people with AIDS, and their T-cell counts--the number of immune cells--had to have dropped below 200.

The study began in early 1986 with 282 patients at 12 medical sites around the country. The first step in this process was to hire principal investigators, or PI's--researchers at leading medical schools and hospitals who designed the AZT trial as a double-blind, placebo-controlled trial: Give half the patients the drug, the other half a placebo, and see which group fares best. Not even the doctors know who gets the real thing.

But the AZT trials in which 145 people with AIDS were on AZT and 137 on a placebo, were unblinded almost immediately. Patients knew right away who was getting what. The AZT pills tasted bitter, and the side effects tore up the gastrointestinal tract, causing nausea, vomiting and a loss of appetite; a severe atrophy made their muscles feel like wet spaghetti. Not to mention acne, pounding migraines, impotence and high fevers.


And continues with this:


The People With AIDS Coalition in New York set up a hotline to analyze patients' pills. If patients weren't receiving AZT, they often bought the drug on the black market. According to Michael Callen, one of the founders of the PWA, some patients shared their pills with those on placebos out of a sense of solidarity.

Within a month, doctors also knew who was on what. According to FDA reports, nearly half the people taking AZT developed such severe anemia that they needed blood transfusions, so patient care was hardly identical. The AZT was devouring their bone marrow, which produces the immune-system cells that HIV attacks, so it was accelerating the very process it was supposed to stop. Some patients were so weak they couldn't get out of bed. Twenty-seven were taken off the drug temporarily, another 21 altogether.


And then we are back to page 4 of this sordid story that I began with in my initial reply to Maslo regarding the NIAID quotation featured in Wikipedia. Let's revisit that Wikipedia quotation from the NIAID report:


The NIAID reports that, "In the mid-1980s, clinical trials enrolling patients with AIDS found that AZT given as single-drug therapy conferred a modest survival advantage compared to placebo. Among HIV-infected patients who had not yet developed AIDS, placebo-controlled trials found that AZT given as single-drug therapy delayed, for a year or two, the onset of AIDS-related illnesses. Significantly, long-term follow-up of these trials did not show a prolonged benefit of AZT, but also did not indicate that the drug increased disease progression or mortality. The lack of excess AIDS cases and death in the AZT arms of these placebo-controlled trials effectively counters the argument that AZT causes AIDS. Subsequent clinical trials found that patients receiving two-drug combinations had up to 50 percent improvements in time to progression to AIDS and in survival when compared to people receiving single-drug therapy. In more recent years, three-drug combination therapies have produced another 50 to 80 percent improvement in progression to AIDS and in survival when compared to two-drug regimens in clinical trials."[53] "Use of potent anti-HIV combination therapies has contributed to dramatic reductions in the incidence of AIDS and AIDS-related deaths in populations where these drugs are widely available, an effect which clearly would not be seen if antiretroviral drugs caused AIDS."


Under this context, there are many things just do not add up and it appears as if someone is lying. Perhaps it is the journalist Linda Marsa who made up a big fiction, perhaps the NIAID is lying, or perhaps "truth" is in the eye of the beholder. What seems certain, not just to myself but clearly others in this site, is that we shouldn't just take the "experts" of this site who think they shouldn't have to be bothered "digging up" all the "numerous studies" that "debunk" the valid questions that are being asked.

I am thankful to Maslo for making his effort in offering that needed intelligent counterpoint that has been sorely lacking in this thread, and hope he will stay with it. I know I will.



posted on May, 24 2012 @ 11:25 PM
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Regardless of a person's stance, that article from the LA Times JPZ is a good read and sheds light not only into the debate of HIV/AIDS, but how a drug maker can see a corner on a market and seize it with nary an oversight from the supposed gatekeepers; the FDA.

No long term studies? The control-group was questionable? Severe side-effects? And this drug was ushered in and rewarded with mounds and mounds of cash.

Something that struck me in the article though was that AZT was shown to have anti-HIV properties, but the author continually mentioned the drug was given to AIDS patients. Maybe I am missing something?!



posted on May, 24 2012 @ 11:34 PM
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reply to post by ownbestenemy
 





Something that struck me in the article though was that AZT was shown to have anti-HIV properties, but the author continually mentioned the drug was given to AIDS patients. Maybe I am missing something?!


It is the language trap that was set for everyone. Heidegger once said that we do not speak language, language speaks us. This can be true, but not necessarily so. Indeed, what kind of foolishness is this? That humanity invents language only to have language invent us? People rarely consider the language they are using. Someone calls an international press conference and declares they've found "the probable cause" to AIDS, and the media runs with this and declares that the cause of AIDS has been found, before you know it HIV is synonymous with AIDS...and perhaps it is...or perhaps not...



posted on May, 24 2012 @ 11:43 PM
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In the early 80s I was flying guys back from Africa with what they labeled back then as hepatitis, but was later determined to be HIV. Kind of wild times back then when people really didn't know what they had and how contagious it was.

The future cure seems to be in the form of HIV strains that do not lead to AIDS. There are strains in Africa where the host has had it for many decades with no advancement to AIDS, and once a host gets a strain then no other strain can connect to the same receptors too. This would make one immune to all AIDS causing HIV strains.



edit on 24-5-2012 by Xtrozero because: (no reason given)



posted on May, 25 2012 @ 08:42 AM
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reply to post by Xtrozero
 


That's how they used cow pox against small pox.



posted on May, 25 2012 @ 09:24 PM
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Originally posted by CynicalDrivel
reply to post by Xtrozero
 


That's how they used cow pox against small pox.


I'm not sure. I thought that since cow pox was close to small pox the body designs T cells for it that also work on small pox...kind of like the defense is in place at the very beginning.

HIV is different than this since it is a simple virus. It needs the cell to live and it attaches itself to specific receptors, and if something is already attached then it can't get a foot hold. This is why a live HIV needs to be used so it attaches itself and the host lives a normal life never developing AIDS.



posted on May, 26 2012 @ 07:54 PM
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I'd say that I sometimes get concerned when people just throw a film like "House of Cards" into a thread unconditionally, and then I'd mention AIDStruth.
It's not my favorite site, or something I enjoy reading.
I just think sometimes some of the denialist material is extremely alarmist, so it's good to have one site to make people think twice before they believe any old nonsense on HIV/AIDS.
A lot of denialism focuses on making AIDS activists and the medical system look bad.
Essentially it's an implied charge of genocide via AZT involving a huge conspiracy of medical workers, patients, activists, novelists, and so forth - people who are inventing AIDS for profit, or too stupid to realize they are just pushing a word-game of sorts.
So I don't think it's unfair to have a site that shows the other side of the coin.
It might not be the best frame to discuss people like a cult, and ultimately they could say like the Jehovah's Witnesses: "Our denying blood transfusions have only killed so many, what about all those with blood transfusions who die also?"
Does that argument make blood transfusions safer or not, or is it irrelevant?
Similarly with HIV, if my CD4 count goes under 250 it is my choice to take the ARVs.
I will do so based on a huge convergence of evidence that has become obvious to me, not because of AIDStruth, which is really just a quick counter-site to Internet denialism (at least for myself).
A lot of people felt that creating a site on denialism actually credits it, and a better response would have been to ignore it completely.

However, when we call HIV/AIDS or "AIDS denialism" political that becomes more complicated, and in a non-clinical sense I feel we've paid too little attention to this.
In the US AIDS denialism has had both left-wing and right-wing moments.
Viruses may exist, but the discourses we create around them indeed influence how they spread through bodies, and how they respond to genes and environmental factors.
So personally I think there is something we can learn from AIDS denialism (especially with prevention).
The problem is that HIV/AIDS still carries so much stigma - perhaps people are not ready for a greater synergy in theory yet, because until now politicians have used it to make it seem like something will be taken away and denied: we'll be left to die without life-saving ARVs/we'll be poisoned.
It's become tantamount to a struggle between a good God and an evil Devil about individual souls.
And indeed, there's been evil people on both sides.
But at the end of the day, it's my choice, and one website isn't going to make that choice for me.
I'd like to see a discourse where people can build, and nobody feels endangered.



posted on May, 26 2012 @ 11:16 PM
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Blood on the Page: Interviews with African Authors writing about HIV/AIDS by Lizzy Attrree (Cambridge Scholars' Publishing, 2010).

Interview with Sindiwe Magona (author of Beauty's Gift), July 2006:

LA: What has motivated you to write stories about HIV/AIDS?
SM: One family lost two young women, the other family lost one. Four girls, at least four young women, from five families ... I mean, this is just one block in the street. I can't believe how many young people we have lost ... It's bewildering ... In the township we use the euphemisms ... Gawulayo, the chopper, it literally means that which 'chops.'
(pp. 33-35)

Now one doesn't get the feeling that people were just suddenly dying from a "word game".

The saddest single story must however belong to Khabzela: The life and times of a South African, written by the biographer Liz McGregor.
Shortly, Khabzela was a famous radio personality in SA, who tested positive for HIV, seemingly at a late stage of the viral progression.
Despite massive funding and support (which was then denied most of the poor in SA, 2003-2004) Khabzela eventually believed in a range of denialists, and stopped his successful ARV treatment in favor of herbal and vitamin "immune boosters". Shortly before his death they were even administered intravenously by a crazy Dutch nurse, Tine van der Maas, who felt she could "cure" anything with a good dose of Africa's Solutions, although she still gets credit for getting her hands dirty while most denialists are theorists only, far from any hospice situation www.beatit.co.za...
I think that book was a big wake-up call in SA, and how we should pay big money for absolute nonsense that does not work, when we can have real medicines.

Then we had Edwin Cameron's Witness to AIDS and Adam Levin's Aidsafari, and despite being at death's door, and side-effects at first, they are still very much alive, healthy and on ARVs.
So one can draw one's own conclusions.

I had an HIV-poz date recently who was almost dead with a CD4 count of about 50, and now on ARVs his count is 900 (which is better than mine), and he's living a relatively normal life.
He first got the medication from an international pilot project in our city almost a decade ago, and he's still on the same cocktail, and he says it saved his life.

So what must I say, ARVs kill people when my experience is the opposite?

edit on 26-5-2012 by halfoldman because: (no reason given)



posted on May, 26 2012 @ 11:56 PM
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I really appreciated this post. I think what he says so well is that all roads need to be explored to get to the truth, and there has been an intentional blocking of that.

I wonder though, if HIV ( as in the specific virus Gallo THINKS causes AIDS) is not in fact the direct cause of AIDS, if not the only, then what about the success' with current HIV Patients living with the disease and taking modern medicines to keep the viral load down?



posted on May, 27 2012 @ 04:40 AM
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Originally posted by SamLuv
I really appreciated this post. I think what he says so well is that all roads need to be explored to get to the truth, and there has been an intentional blocking of that.

I wonder though, if HIV ( as in the specific virus Gallo THINKS causes AIDS) is not in fact the direct cause of AIDS, if not the only, then what about the success' with current HIV Patients living with the disease and taking modern medicines to keep the viral load down?


And that is a valid question and observation. Objectively I suppose we should all ask can one contract AIDS without ever being subjected to HIV?

We know that those who are diagnosed as HIV+ have the potential of never progressing to AIDS. Could someone healthy contract AIDS?



posted on May, 28 2012 @ 12:34 AM
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reply to post by ownbestenemy
 





And that is a valid question and observation. Objectively I suppose we should all ask can one contract AIDS without ever being subjected to HIV?

We know that those who are diagnosed as HIV+ have the potential of never progressing to AIDS. Could someone healthy contract AIDS?


In 1994, Reason Magazine published an article written by Charles A. Thomas Jr., Kary B. Mullis, & Phillip E. Johnson,. titled What Causes AIDS?


Leading biochemical scientists, including University of California at Berkeley retrovirus expert Peter Duesberg and Nobel Prize winner Walter Gilbert, have been warning for years that there is no proof that HIV causes AIDS. The warnings were met first with silence, then with ridicule and contempt. In 1990, for example, Nature published a rare response from the HIV establishment, as represented by Robin A. Weiss of the Institute of Cancer Research in London and Harold W. Jaffe of the U.S. Centers for Disease Control. Weiss and Jaffe compared the doubters to people who think that bad air causes malaria. "We have . . . been told," they wrote, "that the human immunodeficiency virus (HIV) originates from outer space, or as a genetically engineered virus for germ warfare which was tested in prisoners and spread from them. Peter H. Duesberg's proposition that HIV is not the cause of AIDS at all is, to our minds, equally absurd." Viewers of ABC's 1993 Day One special on the cause of AIDS-almost the only occasion on which network television has covered the controversy-saw Robert Gallo, the leading exponent of the HIV theory, stomp away from the microphone in a rage when asked to respond to the views of Gilbert and Duesberg.


In 1989, Spin Magazine featured an interview with Robert Gallo:


Gallo: There is no organized body of science that thinks it is anything but comedy with Peter right now. That's the fact. Why does the Institute of Medicine, WHO (World health Organization), CDC (Centers for Disease Control), National Academy of Sciences, NIH, Pasteur Institute and the whole body of science 100 percent agree that HIV is the cause of AIDS? If there was anything to what Peter is saying, wouldn't it occur to you that there would be some other scientists that would agree with Peter? Can you tell me anyone?

SPIN: Walter Gilbert of Harvard.

Gallo: Wally Gilbert believes HIV doesn't cause AIDS?!!

SPIN: He says it remains an open question. He says Duesberg has shown that at least.

Gallo: Wally Gilbert said that?! You want to get that in writing? Get Wally Gilbert to say that in writing! I don't believe Wally Gilbert ever said anything of the sort. He probably doesn't know all the facts. We have had detailed study by the best qualified people and the answer is overwhelming.


In 1988, Gilbert was quoted:


[Duesberg] is absolutely correct in saying that no one has proven that AIDS is caused by the AIDS virus. And he is absolutely correct that the virus cultured in the laboratory may not be the cause of AIDS. ~Hippocrates (Sept./Oct. 1988)~


Reason Magazines very next paragraph I will highlight the beginning:


Such displays of rage and ridicule are familiar to those who question the HIV theory of AIDS. Ever since 1984, when Gallo announced the discovery of what the newspapers call "HIV, the virus that causes AIDS," at a government press conference, the HIV theory has been the basis of all scientific work on AIDS. If the theory is mistaken, billions of dollars have been wasted-and immense harm has been done to persons who have tested positive for antibodies to HIV and therefore have been told to expect an early and painful death. The furious reactions to the suggestion that a colossal mistake may have been made are not surprising, given that the credibility of the biomedical establishment is at stake. It is time to think about the unthinkable, however, because there are at least three reasons for doubting the official theory that
HIV causes AIDS.


While there have been members in this thread who've dismissed articles of this age, articles written "in the 90's", in terms of rage and ridicule, what has changed?

Cont:



posted on May, 28 2012 @ 12:34 AM
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What are the three reasons Reason Magazine lists for doubting the official theory that HIV causes AIDS?


First, after spending billions of dollars, HIV researchers are still unable to explain how HIV, a conventional retrovirus with a very simple genetic organization, damages the immune system, much less how to stop it. The present stalemate contrasts dramatically with the confidence expressed in 1984. At that time Gallo thought the virus killed cells directly by infecting them, and U.S. government officials predicted a vaccine would be available in two years. Ten years later no vaccine is in sight, and the certainty about how the virus destroys the immune system has dissolved in confusion.


Has anything changed since 1994 when Reason made this argument? Certainly not in this thread where so many members, one specifically joining this site to do so, have simply relied on outrage and ridicule to support the contention that HIV causes AIDS. Real Spoke, early in this thread attempted to engage in reasonable discourse, but cited a Wikipedia article that I challenged the first quoted section in this thread on the "summary" of a Deusberg article, and then Real Spoke mysteriously disappeared from this thread.

Later, Maslo made an honest attempt to address the science, even engaging me over the Wikipedia "summary" and more importantly actually turned to scientific papers to defend the HIV theory, but after a bit of discourse now Maslo has mysteriously disappeared.

Continuing with that Reason article:


Second, in the absence of any agreement about how HIV causes AIDS, the only evidence that HIV does cause AIDS is correlation. The correlation is imperfect at best, however. There are many cases of persons with all the symptoms of AIDS who do not have any HIV infection. There are also many cases of persons who have been infected by HIV for more than a decade and show no signs of illness


This was, of course, what Duesberg was arguing in the paper that I contend Wikipedia grossly misrepresented. Has something changed today to take the HIV theory out of the correlation dependency and into some verifiable fact? If so, not a soul in this thread has shown this.


Third, predictions based on the HIV theory have failed spectacularly. AIDS in the United States and Europe has not spread through the general population. Rather, it remains almost entirely confined to the original risk groups, mainly sexually promiscuous gay men and drug abusers. The number of HIV-infected Americans has remained constant for years instead of increasing rapidly as predicted, which suggests that HIV is an old virus that has been with us for centuries without causing an epidemic


Has anything really changed since 1994 regarding this claim? Has AIDS spread through the general population in the U.S. and Europe? If so, not a soul in this thread has demonstrated that.

Reason follows these three reasons to question the accepted HIV theory by stating that no one disputes what happens in the early stages of HIV...


No one disputes what happens in the early stages of HIV infection. As other viruses do, HIV multiplies rapidly, and it sometimes is accompanied by a mild, flulike illness. At this stage, while the virus is present in great quantity and causing at most mild illness in the ordinary way, it does no observable damage to the immune system. On the contrary, the immune system rallies as it is supposed to do and speedily reduces the virus to negligible levels. Once this happens, the primary infection is over. If HIV does destroy the immune system, it does so years after the immune system has virtually destroyed it. By then the virus typically infects very few of the immune system' s T-cell


Has this changed since 1994? Consider what Avert has to say about the early stage of HIV - You know Avert, don't you? That's the site with a "135 clickable links":


STAGE 1 : Primary HIV infection This stage of infection lasts for a few weeks and is often accompanied by a short flu-like illness. In up to about 20% of people the HIV symptoms are serious enough to consult a doctor, but the diagnosis of HIV infection is frequently missed.

During this stage there is a large amount of HIV in the peripheral blood and the immune system begins to respond to the virus by producing HIV antibodies and cytotoxic lymphocytes. This process is known as seroconversion. If an HIV antibody test is done before seroconversion is complete then it may not be positive.


Continued:



posted on May, 28 2012 @ 12:34 AM
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Here is what the San Francisco AIDS Foundation says:


Primary HIV infection is the first stage of HIV disease, when the virus first establishes itself in the body. Some researchers use the term acute HIV infection to describe the period of time between when a person is first infected with HIV and when antibodies against the virus are produced by the body (usually 6- 12 weeks).

Some people newly infected with HIV will experience some "flu-like" symptoms. These symptoms, which usually last no more than a few days, might include fevers, chills, night sweats and rashes (not cold-like symptoms). Many other people either do not experience acute symptoms, or have symptoms so mild that they may not notice them.

Given the general character of the symptoms of acute infection, they can easily have causes other than HIV, such as a flu infection. For example, if you had some risk for HIV a few days ago and are now experiencing flu-like symptoms, it might be possible that HIV is responsible for the symptoms, but it is also possible that you have some other viral infection.


What do they mean by acute?


1. Pointed at the end; sharp.
2. Of or relating to a disease or a condition with a rapid onset and a short, severe course.
3. Of or relating to a patient afflicted with such a disease.


So, what precisely has changed about HIV since 1994? If there has been a change in understanding about HIV that contradicts the Reason article, I don't know what it is, and of course, we have members in this thread who've claimed to do the research, but they're not telling, and some claim there are thousands of studies to refute, but they can't be bothered to dig the information up. So, here we are.

The Reason article continues:


Before these facts were well understood, Robert Gallo and his followers insisted that the virus does its damage by directly infecting and killing cells. In his 1991 autobiography, Gallo ridiculed HIV discoverer Luc Montagnier's view that the virus causes AIDS only in the company of as yet undiscovered "cofactors." Gallo argued that "multifactorial is multi-ignorance" and that, because being infected by HIV was "like being hit by a truck," there was no need to look for additional causes or indirect mechanisms of causation.

All that has changed. As Warner C. Greene, a professor of medicine at the University of California, San Francisco, explained in the September 1993 Scientific American, researchers are increasingly abandoning the direct cell-killing theory because HIV does not infect enough cells: "Even in patients in the late stages of HIV infection with very low blood T4 cell counts, the proportion of those cells that are producing HIV is tiny-about one in 40. In the early stages of chronic infection, fewer than one in 10,000 T4 cells in blood are doing so. If the virus were killing the cells just by directly infecting them, it would almost certainly have to infect a much larger fraction at any one time."


Was this true in 1994, and if so, has this claim changed now? Certainly in this thread, those advocating the HIV theory are not admitting to any other co-factors, even if they are failing, or flat out refusing to offer up any study to the contrary.


Gallo himself is now among those who are desperately looking for possible co-factors and exploring indirect mechanisms of causation. Perhaps the virus somehow causes other cells of the immune system to destroy T-cells or induces the T-cells to destroy themselves. Perhaps HIV can cause immune-system collapse even when it is no long present in the body. As Gallo put it at an AIDS conference last summer: "The molecular mimicry in which HIV imitates components of the immune system sets events into motion that may be able to proceed in the absence of further whole virus."


Is this true? Did Gallo begin looking for co-factors? Bob Lederer reports in Poz Magazine - imagine that a magazine named in honor of being HIV positive - that:


Leading AIDS researchers at the Centers for Disease Control and Prevention now offer similar views, and even Gallo has lightened up a bit. He now says, “Some of Joe Sonnabend’s postulations catalyzed us to move faster” in studying the immune system’s response to HIV. As for his 1987 repudiation of AIDS cofactors, Gallo now says, “I was brasher and younger then.” He still argues that no cofactor is necessary for AIDS, but says he believes several may contribute to disease progression.


Continued:



posted on May, 28 2012 @ 12:35 AM
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The NIH has a feature on their website called In Their Own Words... where in 1995 an interviewer asked Gallo about co-factors:


Harden: Dr. Gallo, it has been some time since we conducted the earlier interviews. We will try to pick up where we left off last time. We were talking about your laboratory's research on the basic molecular biology of HIV. I am interested in some of the spin-offs of the research. I know that you found one or two new human herpesviruses which might be cofactors in AIDS. I would like you to describe the whole idea of cofactors and whether these new herpesviruses are now viewed as cofactors in HIV infection.

Gallo: Just talking generally, the spin-off in terms of the herpesvirus actually did not come out of molecular biology; it came more out of virology/biology experiments with a design, in fact, a plan, to discover new herpesviruses. As usual, the general idea bears fruit, but it is never for the reasons that you predicted. I will come to that in just a second and then we will talk about cofactors.


And Gallo continues...


But, in terms of molecular biology spin-offs, I think the biggest ones are the discovery of new genes within HIV, within the genome of HIV, that have rather novel molecular mechanisms of action, that have, in fact, contributed to molecular biology. Some of those new genes have also become targets for people trying to interfere with HIV replication. Some of them are genes, the tat gene being an example, essential to HIV replication.

Let us turn to the issue that you wanted to talk about, the cofactors. Many people have the idea that if you do not always get a disease from a microbe that causes the disease, then either the microbe does not cause the disease, or something else is required as a cofactor. But this is not true. A microbe may cause disease in a very small percentage of people. That is usually the case. In fact, the usual case is that it causes no disease at all. The determination of whether somebody gets disease or not from a microbe depends on a very large number of factors.


And continues....


The number one factor is, of course, the nature of the microbe. Some are efficient in causing disease, some are not.

Second, it sometimes depends on the host. Most of the time it depends on genetic factors in the host. Sometimes it depends on chance events–the dose–and if that seems trite, there are experimental examples that actually prove that in a number of systems.

Staying with retroviruses, it is clear that in nature–I probably used this example in earlier discussions, but I will use it again–when a cat gets infected by the feline leukemia retrovirus, it usually does not get leukemia; it is usually carrying the virus without leukemia occurring. My belief is that if cats lived long enough, let us say, for 100 years, the majority would get leukemia. There is a chance of genetic events occurring due to the integration of the provirus that eventually leads to leukemia. But it is known that if you inoculate the right dose in a young enough kitten, you get leukemia all the time. This is typical. The same is true with chicken leukemia retrovirus. If you inoculate newborn chicks with a proper dose, most will get leukemia. But, in nature, when chickens get infected as adults, it is unusual for them to get leukemia. So, it sometimes depends on the age of the individual, or on the age of the organism, or on the dose of the microbe. These are chance events. People often do not appreciate that.


And continues....


The third is that sometimes it depends on the genetics of the host and how it handles a given microbe.

The determinants, for example, of HIV, are still unknown, but it could be that there is so much virus variation that different variants may have different virulence. But all the other factors I have just listed may be important.

Now, in my mind, when we talk about cofactors, we have to give a definition. Most people, when they think of cofactors, start to believe that you mean something that is absolutely required to get the disease. I would divide them into categories. I would say that there are essential and non-essential cofactors or, maybe it would be better, to call something a cofactor if it is truly required. Other things are just catalysts or promoters of the probability of getting disease and of the probability of the disease being more rather than less vicious, or more acute rather than it taking a long time to develop the disease. Let us go directly to HIV.


Gallo takes up 13 more paragraphs to answer this question of co-factors, backpedaling, yammering and going on and on and on, to essentially answer yes, there may be co-factors involved.

I highlighted part of what I quoted to point out that in 1995, Gallo made clear at that time that the determinants of HIV were unknown. What does Gallo mean by determinants?



posted on May, 28 2012 @ 12:35 AM
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The World Bank offers a study titled: The determinants of HIV infection and related sexual behaviors : evidence from Lesotho. The NCBI offers this study: Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. The Public Health Agency of Canada offers this study: HIV/ AIDS and Health Determinants: Lessons for Coordinating Policy and Action. PLOS Pathogens offers this study: A Cytoplasmic Tail Determinant in HIV-1 Vpu Mediates Targeting of Tetherin for Endosomal Degradation and Counteracts Interferon-Induced Restriction. The oldest study I just cited was written in 2003, the most recent 2011, and I guess I could be wrong about this, but looking over these abstracts, and summary's made available, it appears that the determinants remain largely unknown, or so varied as to confuse and confound the layman.

Continuing with the Reason article:


But researchers have not been able to confirm experimentally any of the increasingly exotic causal mechanisms that are being proposed, and they do not agree about which of the competing explanations is more plausible. When The New York Times interviewed the government' s head AIDS researcher, Anthony Fauci, in February, reporter Natalie Angier summarized his view as a sort of stew of all the leading possibilities: "It [HIV] overexcites some immune signaling pathways, while eluding the detection of others. And though the main target of the virus appears to be the famed helper T-cells, or CD-4 cells, which it can infiltrate and kill, the virus also ends up stimulating the response of other immune cells so inappropriately that they eventually collapse from overwork or confusion." No other virus is credited with such a dazzling repertoire of destructive skills


Now keep in mind that some of the "debunkers" in this thread have argued that the so called "AIDS denialists" don't even agree with each other.


Perhaps it is the HIV scientists who are collapsing from overwork or confusion. The theory is getting ever more complicated, without getting any nearer to a solution. This is a classic sign of a deteriorating scientific paradigm. But as HIV scientists grow ever more confused about how the virus is supposed to be causing AIDS, their refusal to consider the possibility that it may not be the cause is as rigid as ever. On the rare occasions when they answer questions on the subject, they explain that "unassailable
epidemiological evidence" has established HIV as the cause of AIDS. In short, they
rely on correlation.

The seemingly close correlation between AIDS and HIV is largely an artifact of the misleading definition of AIDS used by the U.S. government' s Centers for Disease Control. AIDS is a syndrome defined by the presence of one or more of 30 independent diseases-when accompanied by a positive result on a test that detects antibodies to HIV. The same disease conditions are not defined as AIDS when the
antibody test is negative. Tuberculosis with a positive antibody test is AIDS;
tuberculosis with a negative test is just TB.


The American Cancer Society offers this definition for AIDS:



The Centers for Disease Control and Prevention (CDC) uses a definition for AIDS that includes a positive HIV blood test along with either a major opportunistic condition or a blood CD4 count of less than 200/mm3. (A normal CD4 count is about 500 to 1,500 cells per cubic millimeter of blood – written mm3.) The opportunistic conditions incl


The Mayo Clinic offers this definition for AIDS:


AIDS is a chronic, potentially life-threatening condition caused by the human immunodeficiency virus (HIV). By damaging your immune system, HIV interferes with your body's ability to fight the organisms that cause disease.


The WHO maddeningly offers this:


Since 1982, many different definitions have been used for national and international reporting. The following list of documents, mostly in PDF format, gives an overview of the most commonly used definitions. We have also included an Excel file with a list of WHO Member States with definitions they are currently using.


Continued...



posted on May, 28 2012 @ 12:35 AM
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From these definitions we understand that HIV causes AIDS because HIV causes AIDS, and I imagine that if you were to ask the CDC, the Mayo Clinic, and the Cancer Society to define a horse they would answer:

Why, a horse is a horse, of course, of course!

However, there are other definitions, such as the Bangui definition which is the 1985 World Health Organization AIDS surveillance case definition, but as Wikipedia points out:


The 1985 WHO AIDS surveillance case definition was heavily criticised, for both medical and political reasons. The 1994 expanded World Health Organization AIDS case definition was introduced in 1994 to incorporate the statement that HIV testing should be done. However, if testing was unavailable, then the Bangui definition should be used.


The Reason article continues:


The skewed definition of AIDS makes a close correlation with HIV inevitable, regardless of the facts. This situation was briefly exposed at the International AIDS Conference in Amsterdam in 1992, when the existence of dozens of suppressed "AIDS without HIV" cases first became publicly known. Instead of considering the obvious implications of these cases for the HIV theory, the authorities at the CDC, who had known about some of the cases for years but had kept the subject under wraps, quickly buried the anomaly by inventing a new disease called ICL (Idiopathic CD4+Lympho-cytopenia)--a conveniently forgettable name that means "AIDS without HIV."[/ex]

I have all ready linked a page briefly describing ICL and Maslo and I briefly debated the ramifications of this, but it rapidly turned into a debate over the toxicity of AZT, because as Reason has all ready pointed out, this issue just keeps getting more complex and more complex.


There are probably thousands of cases of AIDS without HIV in the United States alone. Peter Duesberg found 4,621 cases recorded in the literature, 1,691 of them in this country. (Such cases tend to disappear from the official statistics because, once it's clear that HIV is absent, the CDC no longer counts them as AIDS.) In a 1993 article published in Bio/Technology, Duesberg documented the consistent failure of the CDC to report on the true incidence of positive HIV tests in AIDS cases. The CDC concedes that at least 40,000 "AIDS cases" were diagnosed on the basis of presumptive criteria-that is, without antibody testing, on the basis of diseases such as Kaposi's sarcoma. Yet these diseases can occur without HIV or immune deficiency. Perhaps some of the patients diagnosed as having AIDS would have tested negative, or actually did test negative, for HIV. Physicians and health departments have an incentive to diagnose patients with AIDS symptoms as AIDS cases whenever they can, because the federal government pays the medical expenses of AIDS patients under the Ryan White Act but not of persons equally sick with the same diseases who test negative for HIV antibodies.


Duesberg had argued that the HIV virus did not meet Koch's postulates, but members in this site claim this has been "debunked", and of course "AIDSTruth" "debunks" this by simply arguing the opposite and declaring that HIV does meet Koch's postulates, and how is this so? Why by ignoring the "non-HIV AIDS" patience and declaring them victims of ICL!

Avert offers this explanation:


The definition of AIDS usually requires a positive HIV test. This means that any connection between HIV and AIDS is artificially strengthened because any cases of "HIV-free AIDS" are discounted. In other words, the definition already assumes that HIV causes AIDS, so it can't be used to prove that theory. However, it is possible to redefine AIDS without reference to HIV or even to any other diseases.

The alternative definition of AIDS requires a CD4+ cell count consistently below 200 cells per cubic millimetre of blood, which cannot be explained by any factor other than HIV (such as cancer, malnutrition, radiation or chemotherapy). No HIV test is required.

It turns out that the vast majority of people diagnosed with AIDS fit these criteria. They form a population that barely existed before 1980, but which now numbers hundreds of thousands in the USA and Europe alone. People with such severe immune deficiency are at very high risk of developing serious illnesses and usually die within months (unless they take antiretroviral drugs).10 11 12 We can use this simple, unambiguous definition to test the association between HIV and AIDS.13 14


Continued...



posted on May, 28 2012 @ 12:35 AM
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Wouldn't you know it? Their expanded definitions of AIDS to included HIV, as it turned out, was correct after all. Avert offers up some "clickable links", but [10] is a PDF file of which my converter always fails. [11] however, offers this: Short-term risk of AIDS according to current CD4 cell count and viral load in antiretroviral drug-naive individuals and those treated in the monotherapy era, and this [12]: Short-term risk of AIDS or death in people infected with HIV-1 before antiretroviral therapy in South Africa: a longitudinal study, the 1995 "AIDS Heresies" that I've all ready linked in this thread, and this article: AIDS Treatment News Denialist Series.

Far from offering up some definitive study to "debunk" the notion that their changing of definitions in order to support HIV is problematic, they offer up several studies, and some polemics to do this "debunking". Take their word for it, they've done the studies and if they cannot reasonably explain these studies - few really need any explanations of the polemics - that's your uneducated layman's fault and not theirs. Is it really Avert's or "AIDS Truth's" fault that they cannot seem to find anyone who can reasonably communicate in layman's terms what all this means?


The claimed correlation between HIV and AIDS is flawed at an even more fundamental level, however. Even if the "AIDS test" were administered in every case, the tests are unreliable. Authoritative papers in both Bio/Technology (June 1993) and the Journal of the American Medical Association (November 27, 1991) have shown that the tests are not standardized and give many "false positives" because they react
to substances other than HIV antibodies. Even if that were not the case, the tests at best confirm the presence of antibodies and not the virus itself, much less the virus in an active, replicating state. Antibodies typically mean that the body has fought off a viral infection, and they may persist long after the virus itself has disappeared from the body. Since it is often difficult to find live virus even in the bodies of patients who are dying of AIDS, Gallo and others have to speculate that HIV can cause AIDS even
when it is no longer present and only antibodies are left.


I linked earlier in this thread an article published by the New England Medical Journal that also made this claim and reported of people lives being destroyed because of this, but the "debunkers" in this thread had nothing at all to say about this, instead arguing that the "AIDS denialists" are reckless, irresponsible, and lack compassion.


Just as there are cases of AIDS without HIV, there are cases of HIV-positive persons who remain healthy for more than a decade and who may never suffer from AIDS. According to Greene's article in Scientific American, "It is even possible that some rare strains [of HIV] are benign. Some homosexual men in the U.S. who have been infected with HIV for at least 11 years show as yet no signs of damage to their immune systems. My colleagues . . .and I are studying these long-term survivors to ascertain whether something unusual about their immune systems explains their response or whether they carry an avirulent strain of the virus."

The faulty correlation between HIV and AIDS would not disprove the HIV theory if there were strong independent evidence that HIV causes AIDS. As we have seen, however, researchers have been unable to establish a mechanism of causation. Nor have they succeeded in confirming the HIV model by inducing AIDS in animals. Chimps have repeatedly been infected with HIV, but none of them have developed AIDS. In the absence of a mechanism or an animal model, the HIV theory is based only upon a correlation that turns out to be primarily an artifact of the theory itself


It is getting late, and I am going to have to continue tomorrow as time permits, but this is plenty to look over and make your own determinations for now.





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