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Bexarotene has been approved for the treatment of cancer by the U.S. Food and Drug Administration for more than a decade. These experiments explored whether the medication might also be used to help patients with Alzheimer's disease, and the results were more than promising.
In particular, the researchers were struck by the speed with which bexarotene improved memory deficits and behavior even as it also acted to reverse the pathology of Alzheimer's disease.
"This is an unprecedented finding," says Paige Cramer, PhD candidate at Case Western Reserve School of Medicine and first author of the study. "Previously, the best existing treatment for Alzheimer's disease in mice required several months to reduce plaque in the brain." (OP's note, now this only takes a fraction of the time)
Added Professor Landreth: "This is a particularly exciting and rewarding study because of the new science we have discovered and the potential promise of a therapy for Alzheimer's disease. (...) We are at an early stage in translating this basic science discovery into a treatment.
Bexarotene has a good safety and side-effect profile. The Case Western Reserve researchers hope these attributes will help speed the transition to clinical trials of the drug.
Originally posted by chevy369
My main question is this a long or short answer?
Originally posted by OccamsRazor04
This is welcome news indeed. I work on the geriatric unit in a Psychiatric Hospital, mostly dementia patients. Lewy Body is worse, but a cure for Alzheimers would be wonderful indeed. It's devestating on the family and caregivers.