posted on Jan, 27 2012 @ 04:55 PM
Originally posted by Pervius
Oxycodone (oxycontin) WAS a good drug for people with cancer eating them alive. The Federal Government forced Purdue Pharma to reformulate that drug
and the new 'formula' hit the US market in the 4th quarter 2010. It doesn't work anymore.
Supposedly the Federal Govt said "4 million americans were illegall getting the drug, chopping it up and snorting it"...which required them to
"reformulate it". Make it weaker.
This is actually partially correct. The oxycontin...which is the extended release version of oxycodeine was changed. It was also mixed with Tylenol.
Occasionally aspirin or an NSAID, but because it came in higher doses people were indeed chopping it up and thus getting a higher dose faster.
Opioids work by binding with pain receptors in the brain, preventing the pain signals from binding with them. Tylenol, or acetaminophen, works by
actually "turning off" pain receptors. So it "hopefully" takes less of a opioid to work. Basically there are less pain receptors available for the
narcotic to bind with.
However, most instant release narcotic pain meds are 5-10mg of the drug depending on whether it's hydrocodone or oxycodone. Oxy is slightly stronger
so it takes a little less. The extended release oxycontin is usually 20mg-100 mg...so you can see how devising a method to make it instant release
would be considered a benefit by some people. BUT...again...it was mixed with Tylenol. So..people were also getting a huge immediate dose of
So..they basically took the Tylenol out of the extended release...and lowered the dose that's allowed in the instant release. Personally..there's a
drug called narcan..or naloxone that's an opioid antagonist. It reverses the effects almost immediately. It's my opinion they could add 2 mg or so
of Narcan to the extended release opioid, also making the narcan extended. Basically useless. But...if chopped up...getting the full 2 mg dose of the
narcan even with 60 mg of oxycodone would prevent that high and stop this abuse. And,..it is being done..but only a few pharmaceutical companies do it
to just a few products.
A normal dose for treatment of acute pain is say 4.5 mg of Percocet...or oxycodone. 1 or 2 pills every 4-6 hours. A good number is usually 20 or so.
Insurance companies have long prevented early refils of a drug. So if you came back in 2 days for a refill...or with a new script...they wouldn't
fill it cause the math doesn't work out there. That makes sense.
But if they tried to say....unless it's a terminal cancer patient any patient is limited to say 25 or 30 pills a month. That's insane. I just had
back surgery. I was written a script for 7.5mg of oxycodone 1 or 2 every 4-6 hours. But was given 120 at a time. Legally you can't refill this
script, but you can get another in a reasonable amount of time. But this is the kind of thing I'm assuming this law is trying to regulate. I hate
taking these meds. For many reasons. But....I needed what I was given.
For someone who isn't a medical professional to decide I don't need that much...well...that's just wrong. But we see it in other things too
insurance companies do....like limit the number of days needed for a hospital stay based on what your illness was. Not everyone recovers the same.
Some take longer. Some less. That's a medical decision. Insurance companies are...please understand this is sarcasm and I am not condoning this at
all...but insurance companies acting like this are reasons people go on shooting sprees.
OK...My rant is now over.