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Two trains, one including cars carrying ethanol, were involved in an accident around 1:15 p.m. Friday (2:15 p.m. ET) in Porter County, Indiana, authorities said.
Aerial video footage showed smoke and flames rising from jumbled train cars. It was not clear how the trains made impact.
There was no immediate word on casualties.
Ethanol "is a very volatile flammable liquid and it will take multiple units from the fire department to douse and put this out, said David James of the county's highway department. Area roads were been blocked off.
A collision of three CSX Transportation trains caused a massive chemical fire and possible hazardous chemical spill Friday afternoon in northwest Indiana, according to published reports.
No fatalities were reported. Two crew members were taken to the hospital, but law enforcement officials said their injuries aren’t life-threatening, according to the Chicago Tribune. They were listed in stable condition, a hospital spokesman told CBS Chicago.
The newspaper reported one freight train was stopped for an unknown reason when a second train struck it from behind. The third train traveling westbound on separate tracks could not avoid the two derailed trains and crashed into them, a source told the newspaper.