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Chimp Viruses for Human Vaccines
An adenovirus isolated from chimpanzee feces proves more effective than human adenoviruses as a vaccine vector for hepatitis C.
Human adenoviruses have been proposed as vectors for antigens in vaccines because of their ability to induce strong immune responses in animal models. But there is one major problem—patients that have already been exposed to such adenoviruses naturally develop antibodies against them, which then neutralize the vaccine before it has a chance to deliver its package.
“The body has mounted an immune response, which stays for the rest of its life,” explained Alfredo Nicosia of Okairos in Rome, Italy.
Now, Nicosia and his colleagues believe they have found a solution—use chimpanzee adenoviruses instead.
2011 Convention News .... attendees agreed on one thing —there are going to be more emerging zoonoses in the future
Emerging zoonotic diseases have potentially serious human health and economic impacts and their current upwards trends are likely to continue.
Examples are avian influenza, Bovine Spongiform Encephalitis (BSE) and the Nipah virus. Some of the "lingering" zoonoses are re-emerging in some regions, although they seem to attract less public awareness. Brucellosis, dog rabies and parasitic diseases such as cysticercosis/taeniasis and echinococcosis/hydatidosis for example.
Many factors lead to the emergence of zoonotic diseases. Environmental changes, human and animal demography, pathogen changes and changes in farming practice are a few of them.
2004: Emerging zoonoses on the rise
Concern over the growing list of new and emerging zoonotic diseases—avian influenza, West Nile, monkeypox, and Nipah—drew experts on veterinary medicine, public health, ecology, conservation, microbiology, and disease modeling and forecasting from around the world to the World Health Organization headquarters in Geneva, Switzerland. They met May 3-5 to identify the factors causing diseases to jump from animals to human, and to improve systems for monitoring and controlling zoonoses.