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Enzymes May Hold Key to Diseases A-Z

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posted on Jan, 3 2012 @ 01:17 PM
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Enzymes May Hold Key to Diseases A-Z


www.futurity.org

"Different viruses, such as influenza, Ebola, and measles, hijack proprotein convertases to complete their life cycle and reproduce in the body," …

….proprotein convertases…. fundamental role puts them in the middle of many processes that cause disease—not just cancer and athlerosclerosis, but also Alzheimer’s, anthrax, the flu, and an amazing variety of other maladies.
(visit the link for the full news article)




posted on Jan, 3 2012 @ 01:17 PM
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With a pandemic looming and no real defenses, the race is on to find alternatives to failing anti-virals and inadequate, potentially dangerous vaccines. This research falls into the category of alternative solutions - and focuses on proteins. "Proprotein convertases" are proteins - "secretory proteins" to be exact.


Proprotein Convertases in Health and Disease

Secretory proteins, such as hormones, enzymes, and receptors, constitute a broad group of biochemically active molecules that are essential for cellular function. ….represents an evolutionary mechanism through which complex species maintain homeostasis, nimbly responding to internal and external challenges. At least five classes of proteolytic enzymes have been identified, encompassing more than 66,000 protein sequences classified into 50 clans and 184 families in accordance with their catalytic mechanisms and evolutionary lineages.


Seems everything comes back to proteins -the building blocks of life- including the way flu viruses hijack cells and how they cause disease.



Proprotein convertases (PCs) are a unique family of enzymes that turn a wide range of nonfunctional human proteins into active, functional proteins. Without them, our bodies would not be able to sustain life.

….PCs have been shown to be involved in a wide variety of disease processes. ….They may play a role in the development of various types of cancer, atherosclerosis, Alzheimer’s disease, hormonal disorders, and various important infections, like influenza, anthrax, and numerous other viral and bacterial toxin diseases.

In infectious diseases, various toxins produced by bacteria need to be activated before they can become dangerous—they use PCs to become functional. Different viruses, such as influenza, Ebola, and measles, hijack PCs to complete their life cycle and reproduce in the body.

In Alzheimer’s disease, PCs are necessary for the formation of senile plaques—the brain abnormalities seen in this disorder. All of this stems from the crucial role that PCs play in activating proteins.


In fact, the biggest threat posed by pandemic flu is not the high fatality rate but rather, the chronic disease burden in survivors. Most of the world's nations are squeezed by the already out-of-control chronic disease pandemic - add another generation of flu survivors and who knows what might happen to "democracy"?


a pandemic H5N1 pathogen, or other neurotropic influenza virus, could initiate CNS disorders of protein aggregation including Parkinson’s and Alzheimer’s diseases.



People infected with the bird flu virus - influenza A subtype H5N1 - go through the usual symptoms of fever, aching muscles and cough. The virus is so virulent that 60% of infected humans have died. But according to a study in mice, the infection could also take a more inconspicuous toll on the brain, causing the sorts of damage that could increase the risk of diseases like Parkinson's and Alzheimer's many years after the virus has been cleared.


a pandemic H5N1 pathogen, or other neurotropic influenza virus, could initiate CNS disorders of protein aggregation including Parkinson’s and Alzheimer’s diseases. [NOTE: protein aggregation results from misfolded proteins aka prion infection.]


Vaccines target specific viruses - miss the target and you miss the boat. Unfortunately, pandemic diseases are an easy-to-miss moving target.

Proprotein convertases (PCs) are a "common denominator" in a huge variety of infections and diseases. Artenstein and Opal argue that PCs are potentially rich targets for developing therapies - and could lead to a drug able to treat a variety of problems.


We are interested in developing a therapeutic agent that could be used against a wide variety of different possible infections because frequently scientists cannot easily and rapidly identify the actual culprit in a rapidly spreading epidemic or a bioterror attack.

Therefore, it would be helpful to have a drug that treats a variety of problems.

Because PCs are a common denominator in a large number of infections, we have targeted PCs as a therapeutic strategy in our research.


Go for it. We need all the help we can get. And everyone's mucking around with proteins from Big Pharma to nanotechnology to GM and GE without regard to environmental and other effects - 'bout time someone started paying attention to public health.





www.futurity.org
(visit the link for the full news article)
edit on 3/1/12 by soficrow because: (no reason given)



posted on Jan, 3 2012 @ 01:26 PM
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Nice for the elites to have (in secret of course), but as for us this will never become reality especially when so many industries are posed to lose their cash cows. This coppled with the fact that TPTB want drastic lowering of the population and having a cure-all is simply counter productive to their motives. That's why I wouldn't hold by breath for "verified" cancer or AIDS cures in the future.



posted on Jan, 3 2012 @ 01:36 PM
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reply to post by Chewingonmushrooms
 


Our governments don't always see eye-to-eye with their own corporate handlers, and this may be one of those times. You're right though - there is a depopulation agenda - but the current assessment is, "Houston, we have a problem." Seems a large majority of the population is headed towards debilitation and disability - worse, it's the young and healthy who are being killed off by the current strains of pandemic disease. Ooops.

So it's time to backtrack a bit, make sure there are enough healthy peons around to do the work.




edit on 3/1/12 by soficrow because: wds
edit on 3/1/12 by soficrow because: format



posted on Jan, 3 2012 @ 02:03 PM
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reply to post by soficrow
 


That is some great insight. No government wants their independent population to fall lower than the dependent population. They like to give out those incentives when the birthrate drops below the coveted 2.1%. They want to depopulate for sure, but they want Grandma and her sick, infirm Grandchildren to go first and keep the check givers for awhile longer to pay for the slaughter. I have been following your other thread on the Shenzen case and these are some "real" tangible issues that you are posting.....so great job!
edit on 3-1-2012 by decussation because: (no reason given)



posted on Jan, 3 2012 @ 06:22 PM
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reply to post by soficrow


You're right though - there is a depopulation agenda

 


There is no depopulation agenda in what you are talking about. This is what a depopulation agenda looks like.

There have been a number that have tried it, in Sudan, Cambodia and other places. And while the world was slow to act in some cases, it never turns out well for both sides.



posted on Jan, 3 2012 @ 09:24 PM
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reply to post by boncho
 



There is no depopulation agenda in what you are talking about.


Ya think? ...but what do you think I'm talking about?

Hint:

NCD Pandemic Killing Over 37 Million This Year

The soaring NCD disability rate in relatively young people is a global crisis. Few countries have disability programs; in those that do, about .5 Billion people are classified as NCD-disabled and qualify for help. However, uptake stats from disability programs are misleading; most countries have been tightening their criteria regularly since the 1970's, just to cut costs. As a result, many functionally disabled people do not qualify for support, are not classified as disabled, and are not counted. Rough estimates show 3.5 Billion people suffer from NCDs -half the world's population- and the numbers are growing.

The World Economic Forum (WEF) ranks the NCD Pandemic as one of the top global threats to economic development, describing the Pandemic as an economic issue, "not a health issue." Reports conclude the NCD Pandemic is threatening every nations' productivity, decimating the world's labour force, and draining government coffers to cover escalating costs for healthcare, disability, and more. According to the WEF, the NCD Pandemic will cost $47 Trillion between 2011 and 2020.

......The recommended solution is not to preserve public health but rather, to protect the economy by going after the sick who are draining government coffers and thereby, threatening corporate profits. The first part of the corporate strategy involves 'putting down' the people already incapacitated by dementias and cancer, and then slashing the remaining "mental health" costs.


Also see:
Euthanasia Policies Worldwide (1998)


Legality of euthanasia

Efforts to change government policies on euthanasia in the 20th century have met limited success in Western countries. Euthanasia policies have also been developed by a variety of NGOs, most notably medical associations and advocacy organizations. As of 2011, active euthanasia is only legal in the three Benelux countries: the Netherlands, Belgium and Luxembourg. Assisted suicide is legal in Switzerland and in the US states of Washington, Oregon and Montana.



posted on Jan, 3 2012 @ 09:35 PM
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reply to post by soficrow
 


Misfolded proteins are not in and of themselves prions, or prion diseases. You've said this in other threads and it isn't true.

Would be great if they could come up with a drug that acutely could treat the flu.
edit on 3-1-2012 by Turq1 because: (no reason given)



posted on Jan, 4 2012 @ 10:52 AM
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reply to post by Turq1
 



Misfolded proteins are not in and of themselves prions, or prion diseases. You've said this in other threads and it isn't true.


Yes, I've explained in other threads that "Misfolded proteins are not in and of themselves prions, or prion diseases." I've also explained that sometimes misfolded proteins can become infectious - and when they do, they cause disease. I've also clarified that diseases caused by misfolded proteins go by a variety of names including prion diseases, proteinopathies, tauopathies, and more.

Finding a way to target the underlying and fundamental protein mechanisms and effects of flu and other diseases makes a lot of sense - especially since many of those effects can be long term, and cause debilitating chronic diseases like Alzheimer's, Parkinson's and more.




to add 2nd para
edit on 4/1/12 by soficrow because: (no reason given)



posted on Jan, 4 2012 @ 04:11 PM
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reply to post by soficrow
 





You posted a paper on non-communicable diseases, and then a Christian website that lists states that allow euthanasia.

I don't know what you are trying to say... Do you?




posted on Jan, 4 2012 @ 08:49 PM
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reply to post by boncho
 



I don't know what you are trying to say... Do you?


Yes, I do know what I'm trying to say. ...The world is in the middle of a chronic disease NCD Pandemic that killed 37 million people in 2011 and left millions more disabled - and it's just starting - the diseases are incurable and often untreatable. On top of that, we're facing an infectious pandemic from an as-yet unknown virus that will whip round the world in days when it appears - but we have no effective treatments or vaccine, which must be designed to target specific strains; when this predicted and inevitable infectious pandemic finally does emerge, we will not have adequate time to create treatments or a vaccine. Worse, flu infections trigger chronic diseases that appear decades after the virus clears, including Alzheimer's, cancer and more - all identified as part of the recognized, already occurring chronic disease NCD Pandemic. Which means the fatality and disability rates both will rise dramatically.

These facts are well-known in the hallowed halls of government and corporate board rooms. In September of 2011, the world's corporate leaders from the World Economic Forum (WEF) stipulated that the situation is an "economic issue, not a health issue" - and demanded that governments cut funding to and terminate disability and social health programs. Part of the response to the WEF's demands includes a renewed 'interest' in euthanasia.

Public health authorities that are actually committed to protecting public health are looking to develop treatments that target common denominators in pandemic flu and the downstream chronic diseases - in this case, proprotein convertases.

Does that help clarify?







edit on 4/1/12 by soficrow because: (no reason given)



posted on Jan, 5 2012 @ 06:01 AM
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reply to post by soficrowDoes that help clarify?

 


No. Stop calling it "NCD's" without posting what they are for the people that don't know. Non-Communicable Diseases. As in; lung cancer (cigarettes), alcoholism, obesity (poor diet).

There have been plenty of ways health authorities have been combating this issues. And frankly, most of them annoy me. Is one of the reasons you see a giant spike in statistics because they didn't have proper counting in the past? We are talking about issues that have affected people for hundreds of years.

Although the obesity problem was most likely not an issue during most famines...



posted on Jan, 5 2012 @ 09:33 AM
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reply to post by boncho
 



No. Stop calling it "NCD's" without posting what they are for the people that don't know. Non-Communicable Diseases.


I correctly identified NCDs as chronic disease and posted links for more information. FYI - the disease 'category' was named "chronic disease" in the 1960-70's when the rising epidemics were first recognized. The category was re-named "age-related diseases" in the early 2000's when the numbers started getting really scary, and the social engineers tried to focus on the "aging population." The strategy did not work because the numbers are far too high - the epidemic spread to young people and the developing world, and became pandemic.

When it became clear that most or all chronic disease involves infectious component(s), the name was changed again. NCD - or non-communicable disease - recognizes the infectious nature while emphasizing that communicable does not mean infectious.


As in; lung cancer (cigarettes), alcoholism, obesity (poor diet).


Association does NOT mean causation. You describe factors that influence age of onset, rate of progression, severity and etc - but are NOT causal.



We are talking about issues that have affected people for hundreds of years.


Get real - the pandemic is.


ED to ADD


There have been plenty of ways health authorities have been combating this issues.


Yes - and this is one of them - perhaps the most important and the most legitimate.




edit on 5/1/12 by soficrow because: (no reason given)



posted on Jan, 5 2012 @ 01:58 PM
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I read compulsively, and collect reading material obsessively. I found this article in a free magazine at a doctor's office a couple of months ago, took it away with me and forgot about it. Just found it again and googled it. It helps explain the protein link to flu, cancer and other diseases.


Unlocking Life's Secrets

Manitoba researchers are breaking new ground in the study of proteins - the biochemical compounds that are essential elements in all living cells. Their work may one day lead to new treatments for diseases and conditions ranging from kidney failure to influenza.

…If DNA is the blueprint of life, then proteins are the contractors that essentially build every living cell. Understand how they operate and you can gain new insights into what happens when cells become infected or diseased.

While scientists have always known proteins were important in biological systems, it's only in the last 15 to 20 years that they started to understand the important role they play in co-ordinating how living cells operate, thanks in large measure to advances in mass spectrometry.

…The eventual goal - finding a new class of antivirals - is still years away, he says. "It's not quite like CSI where we can solve this in an hour," says Coombs.

Like much of the other work carried out at the Manitoba Centre for Proteomics and Systems Biology, the results are leading to new insights about illness and disease. But the road to fully understanding the pathways involved in disease and some day finding new treatments is sure to be long, winding and not without its bumps.



posted on Jul, 17 2012 @ 07:08 PM
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reply to post by soficrow
 

The Isles of Langerhans are clogged with millions of dead spirochetes. Thus Diabetes ensues. The arteries are clogged with plaque made up of millions of dead spirochetes . Mad cow's, Parkinson's, Alzheimer's. Lou Gehrig's, a and some strokes are due existing with a 20-year infestation of spirochaetes overcoming the brain as the immune system ages. The victim was bitten by a tick(s) or even Assasin Bugs picked up while outside in the woods. Deer Ticks especially carry these spirochetes . Global Warming has given any tick new kinds of spirochetes today. Treatment : is early massive daily doses of antibiotics to kill these one-celled parasites. Even advanced stages of Alzheimer's show regression and return of memory to many aged individuals in their 80s. It's NIH holding up the real cure, since they stand to be sued and ridiculed for following the wrong ,expensive path of faulty research with loss of face.



posted on Jul, 17 2012 @ 07:15 PM
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Chicken soup!

No, I'm not trying to be funny.

My mom worked in the Medical Field her whole career. She always said when you make Chicken soup use a whole fresh Chicken and make sure to leave the bones in while cooking as apposed to just throwing Chicken breast meat in a pot of canned broth etc. She explained, That way the bone marrow will release "All them good Enzymes" into the broth during cooking. Which is what you need to help fight off what ails you

Could be something to this and her way of thinking.

S & F
edit on 17-7-2012 by SLAYER69 because: (no reason given)



posted on Jul, 17 2012 @ 07:24 PM
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reply to post by soficrow
 

The plaques are from the metabolites of live spirochetes or from the battle of spirochetes with the immune system amoebas and white blood cells,resulting in layers upon layer of dead spirochetes building a clog in the artery or Isles of Langerhans . The victim was bitten by a tick and still harbors millions of spirochetes 20 years later. The cure :is treatment by daily massive doses of antibiotics. Even some persons in their 80's have gotten their memory and mental health back after 9 months of treatment of their Alzheimer's Disease. Parkinson's, Lyme Disease, ALS etc can all be cured with antibiotics.



posted on Aug, 11 2012 @ 02:11 PM
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reply to post by siluriancryptic
 


Ticks and spirochetes may transport disease-causing prions more than anything else - but the underlying mechanisms are still important. Check out antibiotic resistance before you get too excited about the spirochete link.





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