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"Different viruses, such as influenza, Ebola, and measles, hijack proprotein convertases to complete their life cycle and reproduce in the body," …
….proprotein convertases…. fundamental role puts them in the middle of many processes that cause disease—not just cancer and athlerosclerosis, but also Alzheimer’s, anthrax, the flu, and an amazing variety of other maladies.
Proprotein Convertases in Health and Disease
Secretory proteins, such as hormones, enzymes, and receptors, constitute a broad group of biochemically active molecules that are essential for cellular function. ….represents an evolutionary mechanism through which complex species maintain homeostasis, nimbly responding to internal and external challenges. At least five classes of proteolytic enzymes have been identified, encompassing more than 66,000 protein sequences classified into 50 clans and 184 families in accordance with their catalytic mechanisms and evolutionary lineages.
Proprotein convertases (PCs) are a unique family of enzymes that turn a wide range of nonfunctional human proteins into active, functional proteins. Without them, our bodies would not be able to sustain life.
….PCs have been shown to be involved in a wide variety of disease processes. ….They may play a role in the development of various types of cancer, atherosclerosis, Alzheimer’s disease, hormonal disorders, and various important infections, like influenza, anthrax, and numerous other viral and bacterial toxin diseases.
In infectious diseases, various toxins produced by bacteria need to be activated before they can become dangerous—they use PCs to become functional. Different viruses, such as influenza, Ebola, and measles, hijack PCs to complete their life cycle and reproduce in the body.
In Alzheimer’s disease, PCs are necessary for the formation of senile plaques—the brain abnormalities seen in this disorder. All of this stems from the crucial role that PCs play in activating proteins.
…a pandemic H5N1 pathogen, or other neurotropic influenza virus, could initiate CNS disorders of protein aggregation including Parkinson’s and Alzheimer’s diseases.
People infected with the bird flu virus - influenza A subtype H5N1 - go through the usual symptoms of fever, aching muscles and cough. The virus is so virulent that 60% of infected humans have died. But according to a study in mice, the infection could also take a more inconspicuous toll on the brain, causing the sorts of damage that could increase the risk of diseases like Parkinson's and Alzheimer's many years after the virus has been cleared.
…a pandemic H5N1 pathogen, or other neurotropic influenza virus, could initiate CNS disorders of protein aggregation including Parkinson’s and Alzheimer’s diseases. [NOTE: protein aggregation results from misfolded proteins aka prion infection.]
We are interested in developing a therapeutic agent that could be used against a wide variety of different possible infections because frequently scientists cannot easily and rapidly identify the actual culprit in a rapidly spreading epidemic or a bioterror attack.
Therefore, it would be helpful to have a drug that treats a variety of problems.
Because PCs are a common denominator in a large number of infections, we have targeted PCs as a therapeutic strategy in our research.
You're right though - there is a depopulation agenda
There is no depopulation agenda in what you are talking about.
NCD Pandemic Killing Over 37 Million This Year
The soaring NCD disability rate in relatively young people is a global crisis. Few countries have disability programs; in those that do, about .5 Billion people are classified as NCD-disabled and qualify for help. However, uptake stats from disability programs are misleading; most countries have been tightening their criteria regularly since the 1970's, just to cut costs. As a result, many functionally disabled people do not qualify for support, are not classified as disabled, and are not counted. Rough estimates show 3.5 Billion people suffer from NCDs -half the world's population- and the numbers are growing.
The World Economic Forum (WEF) ranks the NCD Pandemic as one of the top global threats to economic development, describing the Pandemic as an economic issue, "not a health issue." Reports conclude the NCD Pandemic is threatening every nations' productivity, decimating the world's labour force, and draining government coffers to cover escalating costs for healthcare, disability, and more. According to the WEF, the NCD Pandemic will cost $47 Trillion between 2011 and 2020.
......The recommended solution is not to preserve public health but rather, to protect the economy by going after the sick who are draining government coffers and thereby, threatening corporate profits. The first part of the corporate strategy involves 'putting down' the people already incapacitated by dementias and cancer, and then slashing the remaining "mental health" costs.
Legality of euthanasia
Efforts to change government policies on euthanasia in the 20th century have met limited success in Western countries. Euthanasia policies have also been developed by a variety of NGOs, most notably medical associations and advocacy organizations. As of 2011, active euthanasia is only legal in the three Benelux countries: the Netherlands, Belgium and Luxembourg. Assisted suicide is legal in Switzerland and in the US states of Washington, Oregon and Montana.
Misfolded proteins are not in and of themselves prions, or prion diseases. You've said this in other threads and it isn't true.
I don't know what you are trying to say... Do you?
No. Stop calling it "NCD's" without posting what they are for the people that don't know. Non-Communicable Diseases.
As in; lung cancer (cigarettes), alcoholism, obesity (poor diet).
We are talking about issues that have affected people for hundreds of years.
There have been plenty of ways health authorities have been combating this issues.
Unlocking Life's Secrets
Manitoba researchers are breaking new ground in the study of proteins - the biochemical compounds that are essential elements in all living cells. Their work may one day lead to new treatments for diseases and conditions ranging from kidney failure to influenza.
…If DNA is the blueprint of life, then proteins are the contractors that essentially build every living cell. Understand how they operate and you can gain new insights into what happens when cells become infected or diseased.
While scientists have always known proteins were important in biological systems, it's only in the last 15 to 20 years that they started to understand the important role they play in co-ordinating how living cells operate, thanks in large measure to advances in mass spectrometry.
…The eventual goal - finding a new class of antivirals - is still years away, he says. "It's not quite like CSI where we can solve this in an hour," says Coombs.
Like much of the other work carried out at the Manitoba Centre for Proteomics and Systems Biology, the results are leading to new insights about illness and disease. But the road to fully understanding the pathways involved in disease and some day finding new treatments is sure to be long, winding and not without its bumps.