I love when these kinds of studies come out. What was the sample size? Did the sample size involve EVERY SINGLE INDIVIDUAL drinking and smoking the
same brand, same frequency, same amount, for the same duration? With each subject's variance from each of these factors, the power of the overall
study decreases. Additionally, was the study conducted entirely in Argentina with an Argentinian population? Are such results appropriate to
generalize to the rest of the world? What were the medical & prior substance abuse histories of the control group? I'm not denying that there may
be a link between smoking, drinking, and decreased sperm count. However, the sweeping conclusions of this study do require a very well-designed
research protocol in order to "prove" anything.
Let's look at the actual abstract from this research:
Fertil Steril. 2004 Aug;82(2):374-7. Related Articles, Links
Effects of alcohol and cigarette consumption on human seminal quality.
Martini AC, Molina RI, Estofan D, Senestrari D, Fiol de Cuneo M, Ruiz RD.
Instituto de Fisiologia, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina.
OBJECTIVE: To evaluate the effects of alcohol or cigarette consumption on seminal parameters in a large population of men attending an andrology
laboratory. DESIGN: Analysis of ten years of data (1990-1999). SETTING: Andrology and Reproduction Laboratory (Cordoba, Argentina). PATIENT(S):
Patients (3,976) were grouped according to nonsmokers; 20 cigarettes/day; nonalcohol consumers; 500 mL of wine or equivalent/day. Patients who
drank alcohol and smoked were also considered. INTERVENTION(S):
A questionnaire was voluntarily filled out by patients. It provided data on drug
consumption and genitourinary diseases. MAIN OUTCOME MEASURE(S): Seminal volume, sperm concentration, motility, viability, and morphology.
RESULTS:
No statistical differences in seminal parameters were found between the degrees of alcohol or tobacco consumption; so, independently of
the degree of consumption patients were considered as smokers or alcohol consumers. CONCLUSION(S): Alcohol or cigarette consumption did not alter
the seminal parameters. Nevertheless, when the patients with these two habits were compared to those without these habits, a significant reduction in
seminal volume, sperm concentration, percentage of motile spermatozoa, and a significant increase of the nonmotile viable gametes were detected. The
synergic or additive effect of these two toxic habits is discussed.
www.ncbi.nlm.nih.gov...
First, we don't know whether their control group was equal in number to their experimental group (which groups nonsmokers as anyone having under 20
cigarettes a day-- any ATS "non-smokers" smoke 19 cigs a day?).
Second, all data on substance abuse was collected via self-report questionnaire (which means that each subject, including nonsmokers + nondrinkers,
had the potential to lie without having any medical confirmation of their nicotine or ethanol blood levels).
Third, "No statistical differences in seminal parameters were found between the degrees of alcohol or tobacco consumption; so, independently of the
degree of consumption patients were considered as smokers or alcohol consumers". This is their result-- essentially they are saying that there was
no differential abuse effect on seminal parameters. In other words, it doesn't matter how much or how little you use, there isn't a statistically
significant effect. Given that there was no effect, the authors decided to group ALL tobacco & alcohol users together. This is a clear example of
using dirty statistics (it is a more imprecise method of seeking a difference).
More research definitely needs to be done on this matter, this particular study is too shoddy to make such sweeping conclusions. Again-- I'm not
denying that there may be an effect. However, I am denying the definitive conclusions that these researchers are making (as well as the
generalization of their results to other populations outside of Argentina).
Perhaps Argentinians have a characteristic way of responding to self-report measures!
Finally: "the effects of alcohol or cigarette consumption on seminal parameters in a large population of men attending an andrology laboratory"
These men were already attending the andrology laboratory when they were approached for research. They were not solicited off the street. In other
words, there was already a problem that brought them to the lab! Thus, this research can NOT be ethically generalized to males that are not
presenting for treatment.
MK
[edit on 7-9-2004 by MKULTRA]