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In a new project, researchers from LIFE -- the Faculty of Life Sciences at the University of Copenhagen -- document that the vesicular stomatitis virus (VSV) plays a previously unknown dual role in the prevention of a number of cancers. The new findings show that the virus both kills cancer cells and stops the expression of the molecules which certain types of cancer cells produce to hide from the immune system.
Researchers believe the work is a major step towards better cancer treatment. The advance would enable the immune system to stop the development of cancer more effectively. In addition, it is possible to mutate the virus and adapt it to the relevant type of cancer. There is thus a potential for a future alternative to chemotherapy, tailored to the individual patient, says Skov.
"The next step will be clinical trials in humans. Such trials are already being conducted in the USA," says Jensen