World's first cancer fighting virus JX-594

Scientists been working on a new approach for cancer treatment and did some advances with a virus named JX-594. Initial results looks promising with 9/10 patient getting better.

Scientists modified the vaccinia virus, which is more famous for being used to develop a smallpox vaccine.

Data just published in the journal Nature suggest that an engineered oncolytic virus called JX-594 selectively targeted and destroyed cancer cells in patients without significantly affecting healthy tissue.

The article in Nature (by Brietbach et al.) — and the media release — describe how JX-594 works in cancer tissues after intravenous infusion. Apparently normal tissues were not affected clinically.

The initial group of 23 patients treated with JX-594 were all patients with advanced, treatment-refractory, solid tumors.

Six of the eight patients given the two highest doses of JX-594 saw their tumors stabilize or shrink. Seven of those eight patients showed evidence of viral replication in their tumors, but not in normal tissues.

Cancer Research UK's Prof Nick Lemoine, also director of Barts Cancer Institute, said: "Viruses that multiply in just tumour cells - avoiding healthy cells - are showing real promise as a new biological approach to target hard-to-treat cancers.

"This new study is important because it shows that a virus previously used safely to vaccinate against smallpox in millions of people can now be modified to reach cancers through the bloodstream - even after cancer has spread widely through the patient's body.

"It is particularly encouraging that responses were seen even in tumours like mesothelioma, a cancer which can be particularly hard to treat."

Might JX-594 have significant clinical activity in prostate cancer?
US engineered virus JX-594 can selectively destroy cancer cells
Trial of Cancer-Fighting Virus Shows Promise

I rea\d up about this a while ago its nice to see the first results are coming back positive!!

nice find.

Not just promising for cancer. Is there any example of a virus being in symbiosis with its host?

reply to post by Mimir

to long to read your clearlly a god for discoverying this may the world bow down to you on there kness

Well - potentially life saving as created - but since we haven't figured out yet how to prevent viruses from mutating into deadly new strains, it seems a little short-sighted to engineer new ones. I hope that this can be used as a treatment without having us regret it later.

Canadian researchers have also done,

Aug 31 (Reuters) - Researchers have shown for the first time that a single intravenous infusion of a genetically engineered virus can home in on cancer, killing tumor cells in patients without harming healthy tissue. Scientists have been intrigued for decades with the idea of using viruses to alert the immune system to seek and destroy cancerous cells. That interest has taken off in recent years as advances in genetic engineering allow them to customize viruses that target tumors. The field received a boost in January when biotech giant Amgen Inc (AMGN.O) agreed to pay up to $1 billion for BioVex, the developer of experimental cancer-fighting virus OncoVex. But the only "oncolytic virus" so far approved by a regulatory agency is for treatment of head and neck cancer in China. In a study published in the journal Nature on Wednesday, scientists at institutions including the University of Ottawa and privately held biotech company Jennerex Inc said a small, early-stage trial of experimental viral therapy JX-954 found that it consistently infected tumors with only minimal and temporary side effects.

reply to post by Mimir


Wonder if they have figured a way to attack this molecular link A5G27, discovered in 2004?

Scientists identify molecular link driving spread of skin cancer - A5G27,
www.abovetopsecret.com...

Also not among the new drugs approved was A5G27 In 2004 Hynda Kleinman and her colleagues at the National Institutes of Health discovered that this molecule, called a peptide, blocks the metastasis of melanoma to the lungs and other organs, at least in lab animals. The peptide also blocks angiogenesis, the creation of blood vessels that sustain metastatic tumors, they reported six years ago in the journal Cancer Research. Unfortunately, A5G27 has not been developed beyond that discovery. Kleinman was working at NIH’s dental-research institute, and, she says, “there was not a lot of support for work in cancer there at the time. They weren’t interested.” She did not have the expertise to develop the peptide herself. “I continued doing cancer research on it, but I couldn’t take it to the next level because I’m not a cancer specialist,” she says. “I was trained as a chemist.” www.thedailybeast.com...

reply to post by Biigs


Thank you.


reply to post by Prince1of2gold


I'm only have influence on mys own and those nearby, Im not even a half god and i didn't come up with the idea to this vacine, only forewarding the info's too you.


reply to post by Open2Truth


If you play with fire your bound to get burned eh?

can only agree with you that they need to be careful about this and test it in depth before its released.

Loads of people die from cancer FAR more that from terror, I would say this is worth more careful scientific research.


reply to post by TheRemedial


Informative video / post.

This shows that because its a old idea there's no money to be made for the pharmaceutical companies and therefoer it risk being ignored.

Yes currently there's a lot of unemployment in some countries, but not everywhere. There would be money in this treatment for those governments who need more people working. With a cure they solved a lot of long term health issues and founded a new work squad.


reply to post by newcovenant


I dont think there is a link between the A5G27 and JX-594, but i dont know.

There are suggestions that initial development may be focused forms of solid tumor, such as melanoma and liver cancer.

Nice thread you made there a shame about the interest.

More results from the studies of JX-594 vs. cancer. This treatment looks prommising, 8/11 measureable persons had small improvements and there was a radical improvement in 7/8 of the measureable patients who is resistant to sorafenib.

ennerex, Inc. announced interim data from its Phase 2 study of JX-594 followed by sorafenib (Nexavar; Bayer and Onyx) for the treatment of patients with advanced liver cancer. The trial has enrolled a total of 15 patients as of Sep 6, 2011, including a subgroup of 10 who have failed previous treatment with sorafenib. All patients were treated with a combination of intravenous and intratumoral injections of JX-594 prior to standard sorafenib therapy. Tumor responses by Choi criteria (a measure of tumor necrosis) in both injected and non-injected tumors were observed in eight of 11 evaluable patients. Tumor responses were maintained for up to 15 months post JX-594 treatment initiation. Significant tumor necrosis following JX-594 and sorafenib was observed in six of seven evaluable sorafenib resistant patients (86%). The sequential treatment regimen was well tolerated, and sorafenib toxicities were consistent with the documented historical profile.

JX-594 is an oncolytic virus that is designed to selectively target and destroy cancer cells. JX-594 is designed to attack cancer through three mechanisms of action: the lysis of cancer cells through viral replication; the reduction of the blood supply to tumors through vascular targeting and destruction; and the stimulation of the body's immune response against cancer cells.Phase 2 Study of JX-594 for Liver Cancer

More info about phase 2 here.