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Single Cell Barcode Chip (SCBC) enables personalized immune function monitoring: A small sample of a patient’s blood contains both white and red blood cells. The white blood cells are comprised of many different cell types, each of which perform various functions that together represent the activity of the immune system. Single immune cells are captured on the SCBC and their functional behavior read out by recording the levels of a dozen functional, secreted proteins for each captured cell.
"This technology has the potential to be used routinely to monitor immune system performance," says Chao Ma, a graduate student in Heath's lab at Caltech's NanoSystems Biology Cancer Center and lead author of the Nature Medicine paper. "For example, it can be directly used to evaluate the effectiveness of certain classes of therapeutics, such as vaccines and other immunotherapies."