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TMZ spoke with Randy's brother, Lanny Poffo, who tells us the wrestling legend suffered a heart attack while he was behind the wheel around 9:25 AM ... and lost control of his vehicle.
Savage was driving his 2009 Jeep Wrangler when he veered across a concrete median ... through oncoming traffic ... and "collided head-on with a tree." Savage was transported to Largo Medical center, where he died from his injuries.