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A controlled clinical trial of DCA for the treatment of congenital lactic acidosis in children found that the drug was well tolerated at a dose of 12.5 mg/kg every 12 hours and blunted the increase in circulating lactate following a meal . Patients received placebo for 6 months and then were randomly assigned to receive an additional 6 months of placebo or DCA. However, the drug failed to improve neurologic outcome. The efficacy of DCA was also evaluated for the treatment of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) . The clinical trial ended early because of onset or worsening peripheral toxicity; all 15 of 15 patients randomized to DCA (25 mg/kg/day) were removed from the trial compared to 4 of 15 patients randomized to placebo. The authors concluded that DCA-associated neuropathy dominated the assessment of any potential benefit in MELAS.
Dr Evangelos Michelakis is living every researcher's worst nightmare. The therapy he painstakingly studied, verified and re-verified, has been hijacked and risks harming the very people it was meant to heal.
Originally posted by alfa1
Did you read the comments in the article (which is four years old now)?
Lauren, 97 minutes ago
If you look at the original paper, you would find that it has been cited in other publications 229 times since 2007. HARDLY 'not being noticed' from a scientific perspective. And clinical trials from benchtop to patients will take YEARS and lots of funding. Abstract: www.ncbi.nlm.nih.gov...
David 54 minutes ago
Actually this is not a joke. I had cancer, my oncologist at Baylor hospital knew about DCA... Two years later and I am still completely cured. It doesn't work on all types of cancer
Even the website cancer.org (The American Cancer Society) says
DCA has been tested in humans on a small scale for rare diseases of metabolism (energy production), but has recently shown some promise in the lab for cancer treatment. This has led some people with cancer to try taking DCA on their own. DCA is known to cause nerve and liver damage, as well as some other side effects. It may also be able to cause cancer in humans, but that has not been proven. At this time, clinical trials (studies on human volunteers) have just been started to find out if DCA might be helpful against cancer. No human studies have been completed yet, so it is unclear how or whether it might help, or what the proper dose might be.
In the 5 patients tested, the drug took 3 months to reach blood levels high enough to alter the tumor's metabolism. At those levels, there were no significant adverse effects. However, at some of the higher doses tested, DCA caused nerve malfunction, i.e. numbing of toes and fingers. Importantly, in some patients there was also evidence for clinical benefit, with the tumors either regressing in size or not growing further during the 18 month study.
I really appreciate hearing your insights on this. It's good to hear the alternative side of the argument.
It is my belief that it's worth more than a handful of researchers located in a couple places looking into.
Originally posted by Revealation
Witholding this makes them an accomplice in every death caused from cancer for which they should be prosecuted.