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In summary, THC completely prevents MDMA-induced hyperthermia, glial activation and DA axonal loss by inducing CB1 receptor-mediated hypothermia. THC anti-inflammatory properties mediated by CB2 receptors also reduced microglia and astrocytes activation induced by MDMA. However, THC receptor-independent antioxidant properties do not seem to contribute to reduce MDMA neurotoxicity. Although it has been previously reported that other drugs reducing MDMA-induced hyperthermia also reduced MDMA neurotoxicity [9], these drugs are not used by potential MDMA users. On the contrary, 95% of MDMA users also consume cannabis [14], [21] and, consequently, THC. Some clinical studies have shown that the use of cannabis and MDMA usually results in neurocognitive deficits and neuropsychiatric symptoms, especially in long-lasting heavy users [38]–[40]. However, clinical data suggest the possibility that THC may protect against the neurotoxic effects of MDMA, since several neurological symptoms were attenuated in THC and MDMA consumers when compared to pure MDMA users [21], [41], [42]. Indeed, the use of THC to prevent MDMA-induced hyperthermia and neurotoxicity does not seem to be an adequate measure. However, this study elucidates the consequences of drug polyuse which is one of the main concerns in the study of drugs of abuse, especially MDMA.
Originally posted by tothetenthpower
So this is kind of for kids ,but offers a GREAT explanation of all most common forms of drugs and their effects on people.
learn.genetics.utah.edu...