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Memories fade with time, often to the annoyance of those who can’t recall important details. But scientists have now found a way to boost the recall of memories even after they’ve started to fade. Unfortunately, the method involves injecting an engineered virus directly into the brain, so those of us who are bad with names may want to wait a bit for the technique to be refined.
The work was done in rats, and the memories in question are associations between a specific taste — saccharine, for example — and an unpleasant stimulus, caused by injection of a nausea-inducing drug (the approach is called “conditioned taste aversion”). Unless the unpleasant association is reinforced, the memories will slowly fade with time, although the aversion doesn’t disappear entirely during the two-week period that the authors were looking at.
Two years ago, the same authors found that it was possible to radically accelerate this fading. By injecting a chemical that blocked a specific brain enzyme (protein kinase M ζ), the authors caused the rats to act as if they had never experienced the nausea, even if the memory manipulation took place 25 days after the conditioning. Most chemicals that interfere with memories tend to prevent them from being consolidated for long-term storage, but this chemical seemed to work even after the memory was firmly in place.