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Some fungal infections—histoplasmosis, blastomycosis, coccidioidomycosis, and paracoccidioidomycosis—can be serious in otherwise healthy people. The fungi that cause these infections exist in the environment in various parts of the world. Therefore, some fungal infections are more common in certain geographic areas. For example, in the United States, coccidioidomycosis occurs almost exclusively in the Southwest. Histoplasmosis is especially common in the Ohio and Mississippi River valleys. Blastomycosis is particularly common in the eastern and central United States (and in Africa).