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Images from NBC station WCAU showed flames reaching hundreds of the feet into the air.
According to reports, debris could be seen blocks away.
Police have closed off the area as a third alarm was sounded for additional crews to respond to the scene and battle the fire that resulted from the explosion. Flames have spread to at least three homes.
Crews from Reading-based UGI are also on the scene, however, there is no confirmation of the explosion being caused by natural gas.
69 News viewers have called from as far away as Center Valley, Pa. saying their homes shook from the explosion
"I was in the basement watching a movie with my granddaughter," Dalrymple said about 11:30 p.m., about 45 minutes after the initial explosion. "All I felt was like a suction and a big boom and I ran upstairs and here my front door was blown open.
"I looked across the street and the house was already in splinters. It just blew up into splinters," he continued, adding he didn't see fire at first. "It caught on fire in like five minutes."
Dalrymple, who grew up in Wilson Borough, where his mother still lives, escaped out the back door with his wife, Terry Elison, and his granddaughter, Kylie Zaun. He said he looked around the corner of his home to see flames coming from the second story of the row home that had been attached to the destroyed home.
Dalrymple said homes in the area are served by natural gas.
"We are just assuming it was a gas explosion because the house is not even there. It's gone," he said.
A new, 16-inch vein is being added to Susquehanna County's natural gas circulatory system in Pennsylvania.
Construction has begun on the Susquehanna Gathering System, a 33-mile pipeline that will carry up to 475 million cubic feet of natural gas per day from Pennsylvania to New York's Millennium Pipeline