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The vaccine targets proteins inside the flu virus that are common across all strains, instead of those that sit on the virus's external coat, which are liable to mutate, the Guardian said.
It is the first vaccine of its type to be tested on people infected with flu. The research was led by Dr Sarah Gilbert of Oxford's Jenner Institute.
The vaccine boosts the number of the body's T-cells, which are important to the body's immune response, identifying and destroying cells infected by a virus.
TORONTO -- An unpublished Canadian study that suggests getting an annual flu shot may make it easier to contract swine flu has caused most provincial governments in Canada to postpone or limit seasonal-flu vaccination programs.
The study remains a mystery in many ways. It is being reviewed for potential publication in a scientific journal, but the authors won't say which one. Few people have seen the data, and some experts have expressed skepticism of the results....
The study is co-authored by researchers from the British Columbia Centre for Disease Control, the Ontario Agency for Health Protection and Promotion and Laval University in Quebec....
The study began after researchers in British Columbia this summer found a possible link between contracting H1N1 and receiving flu shots the previous season, for some people in the province.
The vaccine boosts the number of the body's T-cells, which are important to the body's immune response, identifying and destroying cells infected by a virus.
Normally, when T-cells are no longer working properly they self-destruct in a process called apoptosis. This is to prevent them attacking the body's own cells.
According to Domann, excess free radicals appear to alter the signalling process responsible for apoptosis, prompting functional T-cells to suicide unnecessarily.
Originally posted by ShadowScholar
reply to post by TechVampyre
So you were never vaccinated as a child? Never taken a pain killer? Never had a cold and flu tablet? Ingested food?
If someone wanted to shove something nasty in you, there's little anyone could do to stop it.
Originally posted by ShadowScholar
reply to post by jrmcleod
I'll be first in line to get one of these, the flu sucks.
To everyone chiming in with the oh but what if the government/TPTB have put something in it?
There are already heaps of compulsory injections, these could of course be altered without the need to introduce a whole new vaccine.
That's logic.
NO MORE FLUUUUUUUUUU!
During the trial Dr Gilbert vaccinated 11 healthy volunteers and then infected them, along with 11 non-vaccinated volunteers.
The new vaccine, MVA-NP+M1 boosts these low level responses to very high levels. The next stage will be to test if these t cell responses can prvent people from being infected with 'flu.
Dr Sarah C Gilbert
Reader in Vaccinology, Graduate Studies Advisor, Member of Clinical Biomanufacturing Facility management Committee, Group Head / PI, Grant Holding Senior Scientist, Member of congregation and Supervisor
MVA NP + M1 Influenza Vaccine - Isis Project No 3360
A new flu vaccine developed at Oxford has been shown to be safe and immunogenic in Phase I clinical trials. The vaccine, based on a replication-deficient MVA virus, is able to generate potent T-cell responses.
Marketing Opportunity
A vaccine which avoids the requirement for seasonal reformulation would reduce the risk of new strains of flu becoming common in the 6 month lead time needed to produce the vaccines in large quantities. The Oxford vaccine could also be complementary to other new flu vaccines which generate strong antibody responses.
Isis helps Oxford University researchers to commercialise intellectual property arising from their research: patenting, licensing, spin-out companies.
Isis manages the University’s intellectual property portfolio, working with University researchers on identifying, protecting and marketing technologies through licensing, spin-out company formation, consulting and material sales. Isis funds patent applications and legal costs, negotiates exploitation and spin-out company agreements, and identifies and manages consultancy opportunities. Isis works on projects from all areas of the University’s research activities: life sciences, physical sciences, social sciences and humanities. Isis provides access to Oxford’s expertise and provides researchers with advice on commercialisation.
Sculptures of Isis and Tamesis by Anne Seymour Damer can be found on Henley Bridge downstream at Henley-on-Thames, Oxfordshire.