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Basic Science Research
A primate model of gut, immune, and central nervous system interaction in response to childhood vaccines.
In 2002, Thoughtful House Center for Children embarked on a 5-year collaborative study with researchers at the University of Pittsburgh to develop a primate model for assessing the role of childhood vaccinations in regressive autism. Led by Dr. Laura Hewitson, this non-human primate model for studying vaccine safety enabled us to fully explore the neurodevelopmental, gastrointestinal, and immunologic effects of combined infant vaccine regimens in the most appropriate animal model, the rhesus macaque. Previous vaccine safety studies have tended to examine individual vaccines; none have looked at the potential for synergy and interaction in the context of adverse events. This research model is uniquely capable of providing insights into disease mechanism and cause, as well as having utility in translational studies concerning treatment and prevention.
Based on the success of the pilot study, Phase II of the study is already underway in collaboration with researchers at the University of Washington, Seattle. Phase II is investigating more closely which vaccine(s), or vaccine combinations, result in behavioral and gastrointestinal impairments in infant male rhesus macaques to try to identify any synergistic effects. The study is expected to be completed in 2012.
For more information please see our published papers.
Originally posted by Mary Rose
Dr. Wakefield
Originally posted by Mary Rose
But people have to do their research on this.
Originally posted by Mary Rose
Not true at all.
But people have to do their research on this.
Originally posted by cassini
His research was fraudulent and can quite clearly be demonstrated to be so.
Last week, an article in the British Medical Journal (BMJ), written by a freelance newspaper
reporter, Brian Deer, created a media firestorm in the United States. In his article, Brian Deer accuses Dr. Andrew Wakefield of deliberate fraud regarding his 1998 case series, which was published in the British journal, The Lancet. Dr. Wakefield reported that the children in his case series were suffering from a novel form of bowel disease and that parents reported a temporal link between the onset of symptoms and receipt of the MMR vaccine. Contrary to what has been reported in the media over the years, Dr. Wakefield never stated that the MMR vaccine caused autism. The full text of the original paper is available at www.generationrescue.org
These libelous accusations are based on the flimsiest possible construct. Deer claims fraud on the basis of differences between the case histories in the Lancet study and the children’s private medical records which Deer obtained under questionable circumstances. Since the team at the Royal Free Hospital never had access to the children’s private medical records, it was impossible for them to know what was in them and, therefore, impossible for them to fraudulently report something different. It is standard practice in medicine for a specialist seeing a new patient to take a new history. Of the parents involved in the original study, none have made any complaint, at any time, against Dr. Wakefield. In the case of the only parent we can confirm Brian Deer actually spoke to, Deer used false pretenses and the alias “Brian Lawrence” to obtain the interview. The parent did not turn over any medical records to him.
The undersigned autism organizations, representing thousands of parents, are deeply disturbed by this most recent character assassination of Dr. Andrew Wakefield. This is an attempt to discredit a doctor who has been extraordinarily courageous in treating and researching children suffering with both bowel disease and autism. He has paid a high personal price for his refusal to walk away from children who are suffering and has earned the utmost respect from the families of these children. We believe this is an industry‐driven attempt to shift public attention away from legitimate concerns about vaccine reactions and the development of autism. Science, even controversial findings, should not be distorted by fear or greed.
The truth in this story is that Dr. Wakefield’s findings of bowel disease in association with autism have been replicated (see references) and his work along with that of other doctors has advanced the treatment of these children to the point that the journal, Pediatrics, has published a paper on the treatment for gastrointestinal symptoms in children with autism. The issue of whether MMR is causal for this subgroup of autistic children remains an open question. The epidemiological studies that claim to prove there is no link between the MMR and autism have not had the statistical power to rule out a link for a subset of susceptible children. Much study remains to be done. Attempts to “shoot the messenger” will only result in further erosion of public trust. . . .
Age of Autism
Autism Action Network
Autism Media Channel
Autism One
Autism File Global
Autism Research Institute
Elizabeth Birt Center for Autism Law and Advocacy
Generation Rescue
National Autism Association
Schafer Autism Report
TACA‐Talk About Curing Autism
The Autism Trust USA/UK
The Coalition for SafeMinds
The following peer-reviewed papers support Dr. Wakefield’s original findings:
Furlano R, Anthony A, Day R, Brown A, Mc Garvey L, Thomson M, et al. “Colonic CD8 and T cell
filtration with epithelial damage in children with autism.“ J Pediatr 2001;138:366-72.
Sabra S, Bellanti JA, Colon AR. “Ileal lymphoid hyperplasia, non-specific colitis and pervasive
developmental disorder in children”. The Lancet 1998;352:234-5.
Torrente F., Machado N., Perez-Machado M., Furlano R., Thomson M., Davies S., Wakefield AJ, Walker-Smith JA, Murch SH. “Enteropathy with T cell infiltration and epithelial IgG deposition in autism.” Molecular Psychiatry. 2002;7:375-382.
Wakefield AJ, Anthony A, Murch SH, Thomson M, Montgomery SM, Davies S, Walker-Smith JA.“Enterocolitis in children with developmental disorder.” American Journal of Gastroenterology 2000;95:2285-2295.
Ashwood P, Anthony A, Pellicer AA, Torrente F, Wakefield AJ. “Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology.” Journal of Clinical Immunology, 2003;23:504-517.
The following peer-reviewed papers replicate Dr. Wakefield’s original findings:
Gonzalez, L. et al., “Endoscopic and Histological Characteristics of the Digestive Mucosa in Autistic Children with gastro-Intestinal Symptoms“. Arch Venez Pueric Pediatr, 2005;69:19-25.
Balzola, F., et al., “Panenteric IBD-like disease in a patient with regressive autism shown for the first time by wireless capsule enteroscopy: Another piece in the jig-saw of the gut-brain
syndrome?” American Journal of Gastroenterology, 2005. 100(4): p. 979- 981.
Balzola F et al . “Autistic enterocolitis: confirmation of a new inflammatory bowel disease in an Italian cohort of patients.” Gastroenterology 2005;128(Suppl. 2);A-303.
These are the articles on treatment of gastrointestinal symptoms in autistic children:
Buie T, et al. Pediatrics. 2010 Jan;125 Suppl 1:S19-29. Recommendations for evaluation and
treatment of common gastrointestinal problems in children with ASDs.
Buie T, et al. Pediatrics. 2010 Jan;125 Suppl 1:S1-18. Evaluation, diagnosis, and treatment of
gastrointestinal disorders in individuals with ASDs: a consensus report
Originally posted by Mary Rose
Dr. Andrew Wakefield,[/url] who is working in the U.S. now, about a collaborative project between Thoughtful House and the University of Pittsburgh
I'm glad Dr. Wakefield has a role in the U.S. now advocating for vaccine safety research.
Originally posted by FatherLukeDuke
Originally posted by Mary Rose
Dr. Wakefield
He is just Mr Wakefield now, as he has been struck off for money-grabbing malpractice.
He is no more a doctor than I am.edit on 14/1/11 by FatherLukeDuke because: (no reason given)