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Volume 10, Issue 8 April 15, 2011
Pages 1271 - 1286
Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis, and poor clinical outcome in breast cancer: Achieving personalized medicine via Metabolo-Genomics
Ubaldo E. Martinez-Outschoorn, Marco Prisco, Adam Ertel, Aristotelis Tsirigos, Zhao Lin, Stephanos Pavlides, Chengwang Wang, Neal Flomenberg, Erik S. Knudsen, Anthony Howell, Richard G. Pestell, Federica Sotgia and Michael P. Lisanti
We also suggest that high-risk cancer patients (identified by the lactate/ketone gene signatures) could be treated with new therapeutics that target oxidative mitochondrial metabolism, such as the anti-oxidant and “mitochondrial poison” metformin. Finally, we propose that this new approach to personalized cancer medicine be termed “Metabolo-Genomics,” which incorporates features of both 1) cell metabolism and 2) gene transcriptional profiling. Importantly, this powerful new approach directly links cancer cell metabolism with clinical outcome, and new therapeutic strategies for inhibiting the TCA cycle and mitochondrial oxidative phosphorylation in cancer cells.
Originally posted by cureseeker
reply to post by VneZonyDostupa
Even Metformin comes from a plant and there are many plants which if eaten can mimic the action of Metformin. Good day.
Originally posted by Lebowski achiever
My last appointment with the oncologist yesterday was very positive. The CT Scan showed that the tumors have reduced by half! This is just a great outcome and I am halfway through my Chemo treatments. We have decided on doing 6 and on Thursday I will have my fourth. I am feeling very tired but that is due to aenemia which will be treated by giving me a blood transfusion.