But now for the sinister part of the of this story.
I have presented many credible and diverse sources all claiming the same thing. Metformin is pretty much as close to a silver bullet as we have ever
come. It targets a wide variety of malignancies and both prevents and potentially cures cancer in combination with Chemotherapy. It has a good
track record, without clinical trials, but with large studies, in the field, that shows that it has had some major successes in prevention. This drug
has been on the market for decades and there are, of course, side effects but none that can be prevented by a simple B12 and B6 supplement and staying
away from alcohol. I don’t believe that they weigh up against the benefits.
Now I have reiterated that this drug has been on the market for decades, EXCEPT for the United States. The FDA didn’t approve this drug until
Why this is, is anybody’s guess, but I’ll have a go.
This drug does not have patent protection. It can be manufactured by any pharmaceutical company. It’s gone Generic as they say.
This is also why the Clinical Trials are not done by Big Pharma as there is no money in it . Cancer Institutes and other Charities fund all these
Here is some more History.
Orginal Manufacturer: Merck KGaA. (Original manufacturers of Morphine and Cocaine)
Once they lost their world patent protection (and I cannot seem to find when they did but my guess is also around 1994). In November 1994 Merck
sells Calgon Vestal Laboratories to Bristol-Myers Squibb. After FDA approval in December 1994 Glucophage was manufactured by Lipha Pharmaceuticals Co
(a subsidiary of Merck). of New York City; its U.S. distributor is Bristol-Myers Squibb of Princeton, N.J.
I have found that BMS and Merck have a long history together.
Merck's beginnings can be traced back to Friedrich Jacob Merck's 1668 purchase of an apothecary in Darmstadt, Germany, called 'At the Sign of the
Angel.' Located next to a castle moat, this store remained in the Merck family for generations.
The pharmacy was transformed by Heinrich Emmanuel Merck into a drug manufactory in 1827. His first products were morphine, codeine, and coc aine.
By the time he died in 1855, products made by his company, known as E. Merck AG, were used worldwide. In 1887 E. Merck sent a representative, Theodore
Weicker, to the United States to set up a sales office. Weicker (who would go on to own drug powerhouse Bristol-Myers Squibb) was joined by George
Merck, the 24-year-old grandson of Heinrich Emmanuel Merck in 1891. In 1899, the younger Merck and Weicker acquired a 150-acre plant site in Rahway,
New Jersey, and started production in 1903. Weicker left the firm the following year.
Whether or not Weicker left amicably I have not yet found any evidence on. More than likely they became direct competitors, initially.
BMS lost the patent protection in the US by 2002 (not for the lack of trying. They fought this tooth and nail) after which it became generic and was
manufactured by quite a few more companies.
• Andrx Laboratories, Inc
• Par Pharmaceutical, Inc.
• Watson Laboratories, Inc
• Mylan Pharmaceuticals, Inc.
• Sumitomo Pharmaceuticals
I am still not at the core of this story yet but I feel that I am getting close. Merck and Bristol, Myer Squibb actually have a long history together
but I just can’t find anything above board that reflects this, besides their genesis and the sale of a Merck Company to BMS. There seems to be a
big void of collaboration before that.
Now there has been a bit of discussion on Glucophage (Metformin) shown in the Congressional Record of the House in June 2003
The extraordinary thing is that they are discussing the difference in price between the Germany and the US for the same drug (Glucophage or
Metformin). $5 in Germany and $100 in the US. For a drug that has no patent protection and is manufactured by more than one company in the US. Why so
expensive? Is there price fixing going on? All these questions are yet to be answered.
Kate Stahl, as discussed by Messrs Hoekstra and Gutknecht is a bit of a hero who passed away last year.
…when she reached her mid-70s, and she and her husband could not afford his prescription drugs, she did something about it. She got on a bus to
Canada -- one of the first to head north on a mission to bring back cheaper prescription drugs, a violation of federal law. After that, she became a
dedicated activist, left-wing radical and the sweet, grandmotherly face on a successful national campaign for better pricing of prescription drugs for
These guys are staunch Republicans so it is remarkable that they’re arguments are not really in favour of Big Pharma. They seem straight-laced guys
for the most part from what I have seen, but I of course, would like to know it if that’s not true.
I think the Pharmaceutical Companies are on the one hand price fixing , lying in bed together over patents and distribution rights, and on the other
hand fierce competitors trying to push smaller companies out. However, I would love to hear your input on all of this. This is a few days research
and I am sure that all of us together we can get to the bottom of this.
My question remains. WHY DIDN’T the FDA approve Glucophage until 1994??
As for me: I am taking Metformin. I am not telling my Oncologist and I will start Chemo as soon as possible. I will let you know as to my progress so
you may learn something from this. I will be the ATS Guinea pig so to speak .
I hope this will be a thread that is open for discussion on Metformin, Merck and BMS and the FDA in particular.
edit on 8/1/11 by Lebowski achiever because: (no reason given)