I stumbled upon this thing while reading Duodecim....medical journal...apparently they haven't made news article about it so I thought I post it
edit on 3-12-2010 by SpeDeZo because: Error
This was not the original article but enough since I accidentally posted empty post, which I had to fill quickly....
Here is original translated manually...by hand...
Y-kromosome and epigeneticlal mechanisms, source of difference between genders..
Men and women share similiar genetical components exluding X and Y chromosomes. Scientists have been intrigued for a long time about the meaning of
Y-chromosome, because it contains few genes which encode proteins. While researching on flies (Drosophila melanogaster) researchers found Y-chomosome
affects makeup of other chromosomes. This was found to be connected with activity controlling epigenetical mechanisms.
Conclusion was that Y-cromosome affects partially to differences between genders and activity of the genes...- at least on male flies...
(Lemos Proc Natl Acad Sci USA 2010;107;15826)
Gender affects stressmechanisms
Adrenocorticotropic hormone releaser hormone (CRF) affects in active mental state differently central neural system on males and females. This was
confirmed in a study where effects of CRF were studied on brainstem locus caeruleus noradrnergical activation neurons. This causes changes in mental
activity state, when stress levels increase.
In normal state CRF receiver (CRFr) in locus caeruleus cells is more active in females than in males. CRFr connected more often on females to GTP (Gs)
protein more often than in females. Exposure to stress equalaized this difference by increasing CRFr:n bonding to Gs in males but not on females. At
the same time in males CRFr intake increased, which caused activation of cells caused by stress to lessen. Conclusion is that brainstem cells were
more sensible to small amount of stress in females and adabted worse in bigger quantites of CFR.
(There were refrences to Bangasser Molecular Psychiatry 2010;15:877 )
Here is that golden part...
Epigenetical control mechanisms affect memory and and learning
Amount of rats were subjected to sudden fear, which is saved in memory as conditional reflex for a few months. Then it is thought that long term
learning happens as such that memory primary control moves from hippocampus to brainstem, for example dorsomedallic prefrontalcortex, prelimbical
shell (not sure right translation? ) and (pihtipoimun etuosaan, dunno right translation for that).
In research they followed thee genes related to learning. Firs gene methylation process (Egr1), didn't change after subjection. Second gene reline (?)
methylized immediately after fear subjection, but returned to original state over time. Third gene calciumneurine (?) hypermethyleted after
twenty-four hour period from learning. Gene stayed methylated for a long time all long until the end of the research month.
At the same time when the calciumneurine control areas methylated, both the gene appearance (?) and amounts of protein decreased. Calciumeneurine is
part of synaptical suppression (?). It is then natural that it's activity decreased with metylation in situations, when there was long-term learning.
When methylization process was farmacologically halted, no long term learning occurred.
(Miller Nature neuroscience 2010:13:664)
Scientists then deduced that learning process includes changes in Dna activity levels through changes in local methylation levels. Methylation is then
a part of so called epigenetical control mechanism, which means cells nucleus kromosomethread crease (?) and activity changing mechanisms. Gene
control area cytosinealkali (?) methylisation process leads to decrease in genes activity.
Same research team has proven before that, hippocampus area cells methylation is directly connected to learning. Now published research proves
different methylization processes influence over longtime and sequency of process. (?) Findings fit well with common perception of brain
activityinterconnections. Learning and adaptation requires from the brain ability to change, and there are also epigenetical control mechanisms
I am not sure about my translation so I marked things I was uncertain with question marks.
Everyone, please forgive me for posting originally unfinished thread... My bad....anyone with better skills with scientific language...please correct
me if I made mistakes in my translation. They might have occurred in terminology.
edit on 3-12-2010 by SpeDeZo because: (no reason given)