Originally posted by gsup1
You can see that they tested these drugs that had IC50 ( concentration needed to inhibit 50% of whatever it is you are trying to stop) they ranged
from .3 micro molar ( 300 nano molar ) to 22 micro molar. This is just basic study, they will mostly like try to get those drugs by changing the
structute so that the it will be in the 100-50 nm range. You want nano molar range because you want the drug to be as potent as possible and as less
toxic as possible when you give it in high doses to a patient. The 50 micro molar potency is fine but you need to do better in order to get a drug out
there and find out what exactly in the aloe inhibits the growth of those cells. If you manage to get it down to nano molar, you need to proceed with
mice experiments because you want to see how the drug acts in vivo ( in the body ) and see if it works. Then you would do these experiments in
primates and if they are safe, you go onto humans. I know what you are thinking, this is slow and that is what they are trying to solve on how to find
an animal model that can be used to predict results in humans. In vitro results only give a preview of the POTENTIAL for it to help against a disease.
Basing results on just in vitro experiments ( in the cell culture plates where you cannot simulate the bodily environment ) is not a good
idea.
I think you misunderstand my questioning.
What I was asking is how would one scale nm, etc, from a mouse model, etc, into real life dosages? Reason for such would be to determine how absurd of
amounts of any given thing you would need to take to
try to have results. Inherently, this then equates how absurd it would cost to attempt to
maintain a regimen.
This perspective is important to have people not waste their money on half measures, and bring into reality the scale of potential adverse effects,
for perspective, from trying to actually take how much of etc that would actually be needed.For instance there are many things that are fine in
'small' doses, but if you go and manage to eat half a pound of etc you might have a bad day.
