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The drone targeted a house in Mir Ali area, 30 kilometres (around 20 miles) east of Miranshah, the main town in North Waziristan, a security official and two intelligence officials told AFP.
North Waziristan is known as a hub of Taliban and Al-Qaeda-linked militants.
"It was a US drone strike. The drone fired one missile on a house and the house was completely destroyed," an intelligence official in Miranshah said.