I can't watch the videos right now; work blocks youtube. But thanks for the thread...
Originally posted by concerned190
To greatly simplify the situation: When too much fructose enters the liver, the liver can't process it all fast enough for the body to use as sugar.
Instead, it starts making fats from the fructose and sending them off into the bloodstream as triglycerides.
ALL fructose is metabolized in the liver. It's either stored as liver glycogen or it's essentially converted to VLDL (triglycerides).
Unfortunately, it doesn't end there. VLDL count is directly proportional to LDL count. In fact, the Very Low-Density Lipoproteins are precursors
for Low-Density Lipoproteins.
You mentioned an insulin spike...I'll just expound upon your details. Fructose is considered extremely lipogenic (fat producing). The body can only
store a small amount in the form of glycogen, the rest is ejected into the blood stream as fat. Combine glucose with fructose (Sucrose, High-Fructose
Corn Syrup) and you now have a perfect storm for fat accumulation.
Glucose goes directly to the bloodstream immediately spking insulin levels. Fructose spikes triglycerides after a short period. Generally, insulin
will stay elevated for 2-5 hours after a rush of sucrose, depending on insulin sensitivity. Any excess glucose that isn't burned will eventually be
shuttled, by insulin, to the liver to be "converted" to fat. The presence of insulin alone will shuttle all fats in the bloodstream to the
adipocytes (fat cells) and lock them in until insulin lowers and the body begins to burn fat again for energy.
Glucose spikes insulin, fructose turns to fat....insulin shuttles the fat into fat cells while the body burns sugar for energy.
When bloodsugar is high, insulin locks fat in the cells so your body can clear glucose from the blood.....because it's NOT a good thing to have in
high levels. But once glucose levels subside, insulin levels begin to drop and the body returns to burning fat and adipocytes are "unlocked"
allowing fat to freely flow in and out.
In lab testing, Animals with access to high-fructose corn syrup gained 48 percent more weight than those eating a normal diet especially in the
abdomen, and a rise in circulating blood fats called triglycerides. They wern't just getting fat; they were demonstrating characteristics of obesity,
including substantial increases in abdominal fat and circulating triglycerides, In humans, these same characteristics are known risk factors for high
blood pressure, coronary artery disease, cancer and diabetes.
Here's the study you're referring to:
High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels.
High-fructose corn syrup (HFCS) accounts for as much as 40% of caloric sweeteners used in the United States. Some studies have shown that
short-term access to HFCS can cause increased body weight, but the findings are mixed. The current study examined both short- and long-term effects of
HFCS on body weight, body fat, and circulating triglycerides. In Experiment 1, male Sprague-Dawley rats were maintained for short term (8weeks) on (1)
12h/day of 8% HFCS, (2) 12h/day 10% sucrose, (3) 24h/day HFCS, all with ad libitum rodent chow, or (4) ad libitum chow alone. Rats with 12-h access to
HFCS gained significantly more body weight than animals given equal access to 10% sucrose, even though they consumed the same number of total
calories, but fewer calories from HFCS than sucrose. In Experiment 2, the long-term effects of HFCS on body weight and obesogenic parameters, as well
as gender differences, were explored. Over the course of 6 or 7months, both male and female rats with access to HFCS gained significantly more body
weight than control groups. This increase in body weight with HFCS was accompanied by an increase in adipose fat, notably in the abdominal region, and
elevated circulating triglyceride levels. Translated to humans, these results suggest that excessive consumption of HFCS may contribute to the
incidence of obesity. Copyright © 2010 Elsevier Inc. All rights reserved.
HCFS also inhibits leptin secretion, so you never get the message that you’re full. And it never shuts off gherin, so, even though you have
food in your stomach, you constantly get the message that you’re hungry.
Insulin influences leptin and nearly every other hormone. Many, many studies have shown that Insulin increases hunger.