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It will also close eight plants and scale back operations at six other factories. The changes follow Pfizer's purchase of rival Wyeth last year.
Three plants will be closed in the Irish Republic, leading to the loss of up to 785 jobs there.
Pfizer said it would close two plants in Ringaskiddy, Cork, and another factory in Dun Laoghaire, south Dublin
It is also scaling back operations at Newbridge, County Kildare, and also at the plant at Havant in the UK.