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So even medicine seems to have its less glamorous moments :-)
We are in full agreement here. More research is needed to provide more data.
Interestingly enough, Dr. Myhill proposes a test for CFS. As you see some validity in the concept of ADP/ATP imbalance, do you think that this test could provide a deeper insight into CFS? Do the following statements make scientific sense in your opinion or are they at odds with proven facts?
A Vital Test in Chronic Fatigue Syndrome
The central problem of chronic fatigue syndrome is mitochondrial failure resulting in poor production of ATP. ATP is the currency of energy in the body and if the production of this is impaired then all cellular processes will go slow. It is not good enough to measure absolute levels of ATP in cells since this will simply reflect how well rested the sufferer is. The perfect test is to measure the rate at which ATP is recycled in cells and this test has now been developed by John McLaren Howard. He calls it "ATP profiles". It is a test of mitochondrial function.
Not only does this test measure the rate at which ATP is made, it also looks at where the problem lies. Production of ATP is highly dependent on magnesium status and the first part of the test studies this aspect.
The second aspect of the test measures the efficiency with which ATP is made from ADP. If this is abnormal then this could be as a result of magnesium deficiency, of low levels of Co-enzyme Q10, low levels of vitamin B3 (NAD) or of acetyl L-carnitine.
The third possibility is that the protein which transports ATP and ADP across mitochondrial membrane is impaired and this is also measured.
The joy of the ATP profiles test is that we now have an objective test of chronic fatigue syndrome which clearly shows this illness has a physical basis.
Originally posted by VneZonyDostupa
You have no idea...I consider it a great day when my scrubs don't get a bodily fluid on them =P
Well, there are bits and pieces of good ideas mixed in with bits and pieces of hocus-pocus here, in my opinion. Yes, technically, measuring the turnover rate of ATP would reveal some level of information about a person's mitochondrial function. The problem, however, is how to monitor such a short-lived molecule, especially considering the wide-range of pathways that produce it that DON'T include the mitochodnria. A low level of ATP might be related to a pentose-phosphate pathway problem, a glycogen storage problem, a Cori cycle problem, etc.. Testing ATP turnover seems highly non-specific, so it's not really a reliable means of testing anything.
The other ideas seem more viable, that is, testing substrates or proteins specifically tied to mitochondrial metabolism. We have many of these tests already, as problems with these proteins have already been discovered and classified as "inherited disorders of metabolism". These aren't CFS, obviously, but that's not to say similar problems developed alter in life might not be the culprits.