posted on Apr, 12 2010 @ 06:18 PM
A "recently" discovered drug (1965) that has previously been investigated successfully as a life-extending mechanism, has now been shown to reverse
the symptoms of Alzheimer's Disease.
Rapamycin (also called Sirolimus and trademarked as Rapamune) is actually the byproduct of a specific bacterium. The drug has been used to fight
rejection in patients undergoing organ transplant.
Studies in 2009 revealed additional information about the drug when mice that were administered Rapamycin experienced extended lifespans of up to
New studies, released earlier this month (April 2010), have now demonstrated that Rapamycin enhances memory and cognitive abilities in mice with
Alzheimer's Disease. The two studies verified the other's conclusions and indicate that Rapamycin lowers the levels of toxic molecules that are
believed to cause some of the symptoms of Alzheimer's Disease, like memory loss.
Says Physiologist Veronica Galvan, co-author of one of the scientific papers:
The fact that we are seeing identical results in two vastly different mouse models of Alzheimer's disease provides robust evidence that rapamycin
treatment is effective and is acting by changing a basic pathogenic process of Alzheimer's that is common to both mouse models. This suggests that it
may be an effective treatment for Alzheimer's in humans, who also have very diverse genetic makeup and life histories.
Rapamycin's name is derived from Rapa Nui, the indigenous name for Easter Island. The bacteria which output Rapamycin were first found in soil
samples from the Polynesian island. The drug is synthetically produced by laboratories.
Rapamycin has also been used to treat cancer, fungal disorders, autism, coronary blockages, etc. With previous FDA approval, the drug can be
immediately used for "off-label" purposes, though there have been no trials on humans and it is unknown whether the drug would only thwart
Alzheimer's symptoms or reverse them.
Previous Related ATS Threads:
Elixir of Life Discovered
Scientists discover Easter Island 'fountain of youth' drug that can extend life by ten
Abstracts Of The Two Scientific Papers:
The Journal of Biological
Link To Second Study