Doc Who Tied Vaccine to Autism Ruled Unethical, page 1
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Topic started on 1-2-2010 @ 05:53 PM by Jenna

Doc Who Tied Vaccine to Autism Ruled Unethical


news.yahoo.com
In 1998, Andrew Wakefield, a gastroenterologist at London's Royal Free Hospital, published a study in the prestigious medical journal Lancet that linked the triple Measles, Mumps and Rubella (MMR) vaccine with autism and bowel disorders in children.

[...]

Wakefield's study has since been discredited, and the MMR vaccine deemed to be safe. But now medical authorities in the U.K. have also ruled that the manner in which Wakefield carried out his research was unethical.
(visit the link for the full news article)


Related News Links:
www.time.com


reply posted on 1-2-2010 @ 06:33 PM by americandingbat
This entire episode has been such a disaster for everyone involved, in my opinion.

It has polarized people on the topic of vaccine research in a way that is detrimental to both our own health and our public health.

So much energy has gone into refuting the claims first raised by this man that other, less sensationalized but more well-founded concerns have been neglected.

People in the anti-vaccine camp often seem to forget that the panic actually began with this study, published in one of the pre-eminent "establishment medicine" journals, and refuse to believe anything published by mainstream medicine since. The Lancet may now regret publishing Wakefield's work in 1998, but they did publish it. One of my concerns is that the repercussions of that decision may make them less likely to publish controversial claims in the future, since they have this example of what the media and blogosphere can spin them into.

On the other side, the medical establishment has become so defensive about vaccination that it feeds into the very fears it's trying to squash. The defenders of the MMR vaccination sometimes resort to ad hominem bullying and ridiculing without ever asking themselves to pause and reexamine the issues to see if there's anything to the concerns.

Bad conclusions are the results on both sides, as in the thimerosal-autism link argument. Remove the thimerosal from the MMR vaccine, and we don't see any decline in autism rates. That seems pretty clear. But the two "conclusions" I've seen drawn from this are false conclusions and perpetuate the polarization:

1) even though thimerosal was removed from the final product, mercury is still used in the production process, therefore the removal was a scam and mercury is still causing autism.

2) thimerosal was removed and rates didn't go down, therefore vaccination cannot be involved in autism rates.

Both ignore the possibility that there could be some other connection. I'm not saying there is, personally I'm leaning toward the idea that there are environmental factors where exposure through vaccination may be a very small but still possible route, but where more common exposure through food, air, other products is more important. I'm just saying that the hype has made it seemingly impossible for people to think clearly on any side of the issue.

And of course, on both sides of the issue there are other factors (money, ego) that further muddy the waters.

What a disaster.


reply posted on 2-2-2010 @ 09:39 AM by Jenna
Originally posted by americandingbat
The defenders of the MMR vaccination sometimes resort to ad hominem bullying and ridiculing without ever asking themselves to pause and reexamine the issues to see if there's anything to the concerns.


This happens on both sides, not just from defenders of MMR vaccines. It's unfortunate really. Both sides of the debate are so entrenched in their position that they can't do anything but bully and ridicule the other side. The result being that the debate gets nowhere and really ends before it even begins. Threads here on the topic, the ones I've read at any rate, turn into nothing more than an opportunity for people to declare which side their on.

I suspect that there is more than one factor that comes in to play when it comes to the cause of autism. If it were solely vaccines, then everyone who's gotten one should have autism but they don't. In my extended family (roughly 50-60 people) every one of us have had our vaccines, only one has autism. Definitely not a very large sample size, and nowhere near being scientific, but it leads me to believe it's not solely the vaccines or heredity behind it. Perhaps one or both in combination with something else, but not either of them on their own.

I've also wondered how common it actually was before someone gave autism it's name and it became diagnosed more frequently. It's not outside the realm of possibility that it's not something new that popped up recently but has actually been around for centuries. I'd say it's frequency before being named would probably be practically impossible to discover, but it's a thought I've had.


reply posted on 2-2-2010 @ 02:21 PM by americandingbat
Originally posted by Maxmars
From whence did the "new" information come, and why did it take twelve years to figure it out.


I found
this at the General Medical Council website -- it's a pdf of the report of the "Fitness to Practise Panel Hearing" on Dr. Wakefield, Prof. Walker-Smith, and Prof. Murch (I believe the last two are the other authors of the original study who have not published retractions).

I've just started reading through it, so I don't know what's in there. But I thought it was a worthwhile thing to link up here.



reply posted on 2-2-2010 @ 03:15 PM by Maxmars
reply to post by americandingbat



Thank you Ding! This should be quite interesting.....


reply posted on 2-2-2010 @ 03:48 PM by americandingbat
Originally posted by Maxmars
reply to
post by americandingbat



Thank you Ding! This should be quite interesting.....


Ah yes, nothing like 143 pages of medico-legal jargon to brighten one's day


reply posted on 2-2-2010 @ 04:57 PM by americandingbat
Originally posted by georgejetson
americandingbat, sorry if this is hijacking your thread.


Not my thread, Jenna's

I'm just an interested observer of this stuff. Right now I'm being particularly interested by the fact that
in 2004 the Lancet published comments on a number of allegations that had been made of improper conduct by the 1998 study authors saying that they did feel there had been a conflict of interest that should have been disclosed (Wakefield being paid by lawyers representing parents who believed their children's developmental and bowel disorders had been caused by the MMR vaccine) but also found that the study itself had been ethically conducted in accordance with the accepted proposal to the British medical ethics board, while now the finding is that there were ethical violations in recruitment and treatment of the cases in addition to the conflict of interest.

As Maxmars pointed out, it's interesting that these violations would emerge after all these years, and particularly after one investigation found nothing.

Of course, the more I read the more I get the impression that the original study was seriously flawed in many ways. I tend to agree with the Lancet's current stance that it shouldn't have been published to begin with. But I object to their current decision to "fully retract this paper from the published record." (Source).

I'm also concerned by this little bit from the Financial Times article on the retraction:

Richard Horton, editor of the Lancet, said he had decided in 2004 not to retract the paper after the Royal Free investigation concluded it was “entirely satisfied” with its ethical scrutiny.

“The big flaw is that everyone takes the whole system on trust and if trust breaks down, everything collapses,” he said, adding that the Lancet now imposed much tougher peer review on controversial papers, withholding those judged likely to spark public misinterpretation.


Tougher peer review on controversial papers? How about tougher peer review and better investigation of conflict-of-interest statements on all papers? And withholding publication if a paper is likely to be misinterpreted in the mass media doesn't sound very good either. I understand the desire (as my first post in this thread suggested, I've been disgusted with the coverage of this issue from both sides). But decisions about whether research should be published shouldn't be based on the potential misrepresentation of their results in the media; that seems dangerously paternalistic.

edit: added link to 2004 comments. You may have to register at the Lancet site to see the article, but you don't have to pay, this particular article is provided for free.

[edit on 2/2/2010 by americandingbat]


reply posted on 2-2-2010 @ 05:17 PM by georgejetson
Originally posted by americandingbat
Of course, the more I read the more I get the impression that the original study was seriously flawed in many ways. I tend to agree with the Lancet's current stance that it shouldn't have been published to begin with. But I object to their current decision to "fully retract this paper from the published record." (
Source).

I haven't looked at this in detail in quite a while, but my mother is a special needs teacher, and I can remember discussing it with her. (It's something that parents ask her about a lot, and it's tough to answer. A lot tougher in person than here on a web forum)

The thing that struck me most about the report is that they seemed to confuse correlation and causation.



Tougher peer review on controversial papers? How about tougher peer review and better investigation of conflict-of-interest statements on all papers?


I work in science myself (not medicine though) and I've become quite disillusioned with the peer review process. It seems it's quite common for somebody to get something to review, which they only give a quick glance at and then get on with their own work.


reply posted on 3-2-2010 @ 07:56 AM by georgejetson
reply to post by Maxmars



I'm not sure that it's as bad as that. In my opinion the peer review process is by in large a sound system, it's just that we've got to keep vigilant as to what's going on. If a high profile journal like the Lancet makes slip ups like this, then heads need to roll.


reply posted on 3-2-2010 @ 11:27 AM by spikey
reply to post by americandingbat



The only people who have generally lost out in the MMR debarcle, is the drug pushers.

Many, many millions of £'s in actual fact.

Quite an incentive to falsify reports and test isn't it.

One only has to look to history to know how these vultures operate, and i guarantee you, their modus operandi has NOTHING to do with caring about people's health.

You can guess the rest i assume.

DON'T take my word for it, i recommend doing your own searching in this area, as i and many others can write dozens of threads and posts, but it won't convince you, unless you see what's going on for yourself.


reply posted on 3-2-2010 @ 03:33 PM by georgejetson
Originally posted by spikey
reply to
post by americandingbat



The only people who have generally lost out in the MMR debarcle, is the drug pushers.

What about all the people who got measles mumps or rubella and suffered serious complications? Did they not lose out? The infection rates for these diseases have increased significantly since the Wakefield report.



Quite an incentive to falsify reports and test isn't it.

This particular dodgy report was filed by the people trying to stop the MMR vaccine, not the ones pushing it.


One only has to look to history to know how these vultures operate, and i guarantee you, their modus operandi has NOTHING to do with caring about people's health.

Look up the history of how small-pox was eradicated. Then get back to me.




DON'T take my word for it, i recommend doing your own searching in this area, as i and many others can write dozens of threads and posts, but it won't convince you, unless you see what's going on for yourself.


You are the one who needs to do some research and open your eyes to the facts.


reply posted on 5-2-2010 @ 12:07 PM by jdub297
reply to post by Maxmars


I have 2 observations on the MMR/Lancet debacle:

I have 2 close relatives who served as administrators in major MHMR institutions. They agree that the diagnoses have changed over time with subsequent publications of the Diagnostic and Statistical Manual of Menatal Disorders (DSM). The underlying conditions have not.

They are fairly confident that pre-natal chemical exposure is directly linked to increased diagnoses of childhood disabilities such as autism and ADHD. They see no significant link to vaccination.

They also agree with this observation:
Tougher peer review on controversial papers? How about tougher peer review and better investigation of conflict-of-interest statements on all papers?


They feel that financial interests have blinded many "peers" in their "review" of studies and reports to such an extent that disclosure should be prerequisite to publication, and that publication should include "contra" (conflicting) citations.

Haven't we seen this conflict played out in other fields with "established scientific consensus" and "peer review" of reports and studies?

My guess is that future scrutiny will result in more of such "revelations," but few, if any, retractions.

jw
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