reply to post by retroviralsounds
-Nothing increases the gene transfer of RNA viruses (or everything increases transfer, either way you look at it, it means the same thing). RNA virus
SNPs, transfers and mutations are nearly completely unknown.
en.wikipedia.org...
Single nucleotide polymorphisms may fall within coding sequences of genes, non-coding regions of genes, or in the intergenic regions between genes.
SNPs within a coding sequence will not necessarily change the amino acid sequence of the protein that is produced, due to degeneracy of the genetic
code. A SNP in which both forms lead to the same polypeptide sequence is termed synonymous (sometimes called a silent mutation) — if a different
polypeptide sequence is produced they are nonsynonymous. A nonsynonymous change may either be missense or nonsense, where a missense change results in
a different amino acid, while a nonsense change results in a premature stop codon. SNPs that are not in protein-coding regions may still have
consequences for gene splicing, transcription factor binding, or the sequence of non-coding RNA.
They are talking about different ways in which SNP’s mutate.
-Again, it does not grab genes. I'll try to explain this. The virus infects the cell, and inserts its genome into the host cell's DNA. When the DNA
is replicated (cell division) it creates more identical RNA viruses. Since RNA has no proof reading function, and polymerases are not perfect, there
are going to be a few mistakes in the new RNA strand... these are the mutations.
Yes but where are the mistakes coming from? The virus is not creating the genes that it itself is made up of.
The cell has some RNA genes and has a variety of processes happening in regards to protein transfers of nutrients. Plenty of scope for a transgene to
have an impact in the viral swarms mutations.
-Again, mutation rates are independant of other organisms, unless H1N1 happens to infect the same cell as say H3N2 (this year's seasonal flu, I
think).
I think you are not talking about rates here but about a new mutated disease.
My concerns over bacterial horizontal gene transfer is about in increase in the rate of gene transfer. Perhaps viral swarms do not change speed, but
none the less if the end result is a mutated virus being transferred to somebody else more often then in this way the mutation rate has been
increased.
(If have a list of new mutated viruses)
The viable quasispecies generation rate maybe impacted, RBV does increase the error rate so definitely we can change virus mutation activity.
I have heard that viruses are mutating about as fast as it can. However the mutations generally do not do any better than the last version. A wider
range of more readily available genes gives the virus a better chance of survival. Antibiotics and heavy metals makes genes more available, more genes
= more chances of success.
-Yes, this is true, but evolution teaches us the mutated viruses that aquire a 'better' gene will overcome those who do not get it.
Exactly – so a viral swarm that receives a better gene becomes the disease that is passed on.
Look I very much want you to be correct but I do think that our actions are causing an increase in viral mutations and horizontal gene transfer and
frankly consider this to be the biggest risk facing the human species.
Perhaps if we turn this around what are your concerns? frankly you have not replied to my questions regarding GMO’s their in a whole insertion
package that is available to as mutating virus including promoters, bacteria and further viruses all inserted with the assistance of an antibiotic
still used in human health.
bacteria are aware of external conditions, so definitely we can impact mutations. It is dumb to think a GMO is irrelevant to a bacteria whose eats by
inserting genes into organisms