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Assuming a 1-megaton nuclear weapon, what are the optimal delivery points to maximize global damage and chaos? We are assuming a 1 megaton bomb due to simplicity - this yield is about twice that of the most powerful fission bomb produced by the US, the Mk 18, which used 60 kg of enriched uranium. With nanofactories, building extremely high-quality centrifuges will become easy, making large quantities of enriched uranium accessible to any organization with uranium ore. We will be able to do with a few centrifuges what previously required hundreds or even thousands.
...In this scenario, it does not really matter who is dropping the bomb. The point is to create as much mayhem as possible. This analysis leans towards detonation targets that do damage to the United States in particular, both because the US has many enemies, and because many countries are economically and politically dependent on a smoothly-functioning US. The attack might be a set-up for a larger operation, occur in the context of a war, or simply be an isolated event. Potential orchestrators of the attack include rogue states like North Korea or Iran, criminal organizations, jihadi organizations, or more sophisticated groups like circles of well-educated and wealthy Americans exploiting abrupt technological transitions to gain power.
In roughly ascending order of severity, the options are:
Originally posted by ravenshadow13
Some of the places on the list are very surprising, though.