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BRAIN regions key to cognition are smaller in older people who are obese compared with their leaner peers, making their brains look up to 16 years older than their true age. As brain shrinkage is linked to dementia, this adds weight to the suspicion that piling on the pounds may up a person's risk of the brain condition.
People with higher body mass indexes had smaller brains on average, with the frontal and temporal lobes - important for planning and memory, respectively - particularly affected (Human Brain Mapping, DOI: 10.1002/hbm.20870). While no one knows whether these people are more likely to develop dementia, a smaller brain is indicative of destructive processes that can develop into dementia.
In the CNS, insulin/IGF-1 signaling cascades have critical roles in regulating and maintaining
cognitive and motor functions. Insulin, IGF-1 and IGF-2, and their corresponding receptors are abundantly expressed in various cell types throughout the brain, including neurons [17,20,21] and oligodendroglia [22-24]. Insulin and IGF signaling pathways utilized by CNS neurons are virtually identical to those present in liver, except that IRS-2 instead of IRS-1 is the major docking protein [17,25]. The highest levels of insulin and IGF polypeptide and receptor gene expression are distributed in the hypothalamus, temporal lobe, and cerebellum , i.e., major targets of ethanolmediated neurotoxicity. Since insulin and IGF mediate neuronal and/or oligodendroglial survival, plasticity, energy metabolism, and neurotransmitter function [17,26-29], sustained impairments in their
corresponding signal transduction cascades would have dire consequences with respect to cognitionand behavior
Heart disease, cancer, possible dementia, and over all lower quality of life are defiantly not worth laziness, over eating, or fast foods.