Before seeking out medication for Exploding Head Syndrome, check out
how dangerous the drug can be, used by some that gave relief.
Clomipramine may have a broad range of side effects:
central nervous system: Often, fatigue, dizziness, lightheadedness, headaches, confusion, agitation, insomnia, nightmares, increased anxiety, seizures
(0.5% to 2%, see above), rarely hypomania or induction of schizophrenia (immediate termination of therapy required), and extrapyramidal side-effects
(pseudoparkinsonism, dyskinesia, rarely tardive dyskinesia) are noted.
Anticholinergic side effects in different grades of severity are quite common: dry mouth, constipation, rarely ileus (paralysis of the large
intestine, life-threatening), difficulties in urinating, sweating, precipitation of glaucoma (may lead to permanent eye-damage or even blindness, if
untreated). The incidence of dental caries may be increased due to dry mouth.
antiadrenergic side effects occur very frequently due to strong central and peripheral blockage of alpha receptors: hypotension, postural collapse
(when patient is rising too fast from lying or sitting position to standing), arrhythmias (sinus tachycardia, bradycardia, AV block, rarely other
forms of cardiac problems). Preexisting heart insufficiency can be worsened.
Most of these side-effects are dose related and/or tolerance will develop with continued use.
Allergic/toxic: skin reactions and photosensitivity with increased frequency of sunburns are seen in a few percentage of cases. Rarely liver damage of
the cholostatic type, hepatitis, and leukopenia or other forms of blood dyskrasia are seen, also severe acute allergy including difficulties in
breathing, skin reaction, chest pain etc.
Other side effects may include heartburn, weight gain, but also nausea and bruxism - teeth-grinding while asleep - (the latter due to the strong
inhibition of reuptake of serotonin).
The drug often causes sexual problems in men (e.g. impotence, ejaculation difficulties). In about 5% of patients, it can instead cause inadvertent
orgasms when yawning.
The Brand name is Anafranil
I think I might rather have the loud noise
[edit on 24-8-2009 by azureskys]