To get permission to fly this is the training to go through to be allowed
Lockheed U-2 Flight - The Training + Extra Flight Scenes
If it went into "space" by mistake, could it come back?

But if it hypothetically did its' engines would not work, as there is no air for the jet engine to breath. But it would be able to eventually come back down due to orbital decay, although it would burn up in the atmosphere, as it is not adequately shielded for re-entry