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The HA sequence of the isolate, A/Sao Paulo/43812/2009, was released at Genbank and has three newly acquired polymorphisms.
One polymorphism encodes for V252M (H3 numbering) and the nucleotide change is found in a limited number of sequences, including those from the 1918 pandemic. Other human H1N1 sequences include 2006 isolates from Peru and H1N1 isolates in circulation prior to the 1957 H2N2 pandemic. These human isolates have V252I. However, V252M is found in the 2001 swine isolate from Hong Kong, A/swine/Hong Kong/NS1659/2001 (see list here).
The second change also is non-synonymous (Q296H), and is found in multiple 2009 pandemic sequences identified worldwide (see list here), including an earlier isolate from Sao Paulo, A/Sao Paulo/2233/2009.
The third change is synonymous and also found in 2009 pandemic sequences (see list here), which are distinct from the isolates sharing the second polymorphisms. However, the synonymous polymorphism is also in the Hong Kong swine isolate providing additional evidence for acquisition via recombination.
July 28, 2009 - TOKYO - Japan has found a third case of Tamiflu-resistant swine flu in a man who had taken the drug to prevent infection, the Tokushima prefectural office said Tuesday.
Just six cases of Tamiflu-resistant swine flu have been reported worldwide.
In a statement, the prefectural health department said the man in his 30s was given Tamiflu after his colleague was infected with the virus this month.
Preventive use of Tamiflu has occasionally given rise to resistant viruses, including those of seasonal flu.
Denmark, Hong Kong and Canada also have reported one case each of Tamiflu-resistant swine flu.
Originally posted by king9072
Probably a front site for one of the vaccine manufacturers haha. You guys go get in line for your vaccines natural selection has been calling your name for quite some time.